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pro vyhledávání: '"Ochi A"'
Autor:
Yukio Ochi
Publikováno v:
Medical Hypotheses. 127:23-25
The theory that antibody (Ab) directed against the TSH receptor (TSHR) (TSHRAb) is the causal factor of Graves' disease seems unlikely. Corticosteroids have not had a curative effect on the hyperthyroidism of Graves' disease despite their effectivene
Publikováno v:
Endocrine, metabolicimmune disorders drug targets. 18(5)
Backgroud and Objective: Antithyroid drugs (ATDs) [methylmercaptoimidazole (MMI) and propylthiouracil (PTU) ] are used to treat hyperthyroidism in Graves' disease. The effect of ATDs and reducing agents (mercaptoethanol, dithiothreitol and cysteine)
Publikováno v:
Endocrine Journal. 57:311-315
We examined the inhibitory effect of thyroid blocking antibody (TBAb) on the thyroid stimulating activity of human chorionic gonadotropin (HCG) and equine CG (ECG). Five TBAb positive sera obtained from patients who had been hypothyroid but were curr
Autor:
Takashi Hachiya, Carol Barrett, Yukio Ochi, Bernard Rees Smith, Masanari Hamazu, Takeshi Miyata, Y. Kajita
Publikováno v:
Thyroid. 19:47-52
Nonionic polymers such as polyethylene glycol (PEG), polyvinyl alcohol (PVA), and dextran amplify the ability of thyroid stimulating antibodies (TSAbs) from patients with Graves' disease to stimulate cAMP production in thyroid cells. Therefore we sou
Autor:
Masanari Hamazu, Atsuo Nagata, Takaaki Sato, Yoshihiro Kajita, Yukio Ochi, Takashi Hachiya, Mitoshi Kunimatsu
Publikováno v:
Endocrine Journal. 55:105-111
TSH receptor (R) binding and cAMP production by bovine (b) TSH-bound to a monoclonal antibody (MoAb) or polyclonal antibody (Ab) to bTSH were examined, using TSH receptor (R) coating tube and porcine thyroid cells. (125) I-bTSH bound-to MoAbs to bTSH
Autor:
L. Schwarz-Lauer, Yukio Ochi, Y. Nagayama, Gregorio D. Chazenbalk, Basil Rapoport, Sandra M. McLachlan
Publikováno v:
Thyroid. 12:115-120
Recently, many exceptions have been reported that undermine the concept that the epitopes for thyroid-stimulating autoantibodies (TSAb) and thyrotropin-blocking autoantibodies (TBAb) lie within the N-terminal and C-terminal portions of the thyrotropi
Publikováno v:
Hormone and Metabolic Research. 33:115-120
The detection of thyroid stimulating antibody (TSAb) activity in the presence of thyroid stimulation blocking antibody (TSBAb) in Graves' serum is difficult because TSBAb blocks TSAb activity. We recently demonstrated that polyethylene glycol (PEG) a
Publikováno v:
Internal Medicine. 39:50-54
A 56-year-old Japanese housewife had been diagnosed as having Graves' disease and was treated with methimazole. When she was referred to our hospital, the serum T3 level was high irrespective of high TSH level. High serum T3 levels were also observed
Publikováno v:
Hormone Research in Paediatrics. 53:20-25
Previously we reported the augmentative effect of nonionic hydrophilic polymers such as polyethylene glycol (PEG), polyvinyl alcohol (PVA) and dextran on thyroid-stimulating antibody (TSAb) activity in porcine thyroid cell assays. We examined whether
Autor:
Takashi Hachiya, Atsuo Nagata, Yasushi Sato, Yoshihiro Kajita, Tsuyoshi Kouki, Takehiro Inui, Yukio Ochi, Kei Yamashiro
Publikováno v:
Thyroid. 8:319-325
Cyclic adenosine monophosphate (cAMP) production during a 5-hour incubation using porcine thyroid cells (PTC) was stimulated significantly more by polyethylene glycol (PEG) 22.5% precipitated fractions (ppt frs) than by PEG 12.5% ppt frs from almost