Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Stephen R. Bloom"'
Autor:
Kerstin Stemmer, Stephen C. Woods, Harvey J. Grill, Jens J. Holst, Alessandro Pocai, Michael A. Nauck, Andreas Fritsche, Richard D. DiMarchi, David A. D'Alessio, Mads Tang-Christensen, Diego Perez-Tilve, Darleen A. Sandoval, Randy J. Seeley, Wolfgang Langhans, Daniel J. Drucker, Stephen R. Bloom, M.H. Tschöp, Brian Finan, Fiona M. Gribble, Timo D. Müller, Peter R. Flatt, Joel F. Habener, Juris J. Meier, Thue W. Schwartz, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 30, Iss, Pp 72-130 (2019)
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, in
Autor:
Johannes Broichhagen, James Minnion, Stephen J. Briddon, Joelle Goulding, Yuval Elani, Alejandra Tomas, David J. Hodson, Maria Lucey, Atsuro Oishi, Tanyel Ashik, Ben Jones, Stephen R. Bloom, Ralf Jockers, Amaara Marzook, Yifan Wang
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, 2021, 100 (4), pp.319-334. ⟨10.1124/molpharm.121.000270⟩
Molecular Pharmacology, 2021, 100 (4), pp.319-334. ⟨10.1124/molpharm.121.000270⟩
The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor and mainstay therapeutic target for the treatment of type 2 diabetes and obesity. Recent reports have highlighted how biased agonism at the GLP-1R affects sustained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34511d92a804b7931f16427b2792ca71
https://hal.science/hal-03535615/file/319.full.pdf
https://hal.science/hal-03535615/file/319.full.pdf
Autor:
Johannes Broichhagen, Guy A. Rutter, Shiqian Chen, Victoria Salem, Alejandra Tomas, David J. Hodson, Amaara Marzook, Phil Pickford, Ivan R. Corrêa, Ben Jones, Maria Lucey, Tricia Tan, Stephen R. Bloom, Yifan Wang
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of glucose homeostasis and has been successfully targeted for the treatment of type 2 diabetes. Recently described biased GLP-1R agonists with selective reductions in β-arrestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27acc82a0ed497e3a25f3a2d81b698af
https://doi.org/10.1101/2021.04.01.438033
https://doi.org/10.1101/2021.04.01.438033
Autor:
Stephen R. Bloom, Alejandra Tomas, Yifan Wang, James Minnion, Ralf Jockers, David J. Hodson, Stephen J. Briddon, Yuval Elani, Ben Jones, Atsuro Oishi, Joelle Goulding, Johannes Broichhagen, Amaara Marzook, Maria Lucey, Tanyel Ashik
The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor and mainstay therapeutic target for the treatment of type 2 diabetes and obesity. Recent reports have highlighted how biased agonism at the GLP-1R affects sustained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad8725786d001417989336251cf9413
https://doi.org/10.1101/2021.04.01.438030
https://doi.org/10.1101/2021.04.01.438030
Autor:
Alessia David, Johannes Broichhagen, Philip Pickford, Shiqian Chen, Ben Jones, Guy A. Rutter, Maria M. Shchepinova, Stavroula Bitsi, Alejandra Tomas, Stephen R. Bloom, David J. Hodson, Frank Reimann, Zijian Fang, Tricia Tan, Victoria Salem, Yusman Manchanda, Edward W. Tate, Ivan R. Corrêa
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 21
International Journal of Molecular Sciences, Vol 21, Iss 8404, p 8404 (2020)
Volume 21
Issue 21
International Journal of Molecular Sciences, Vol 21, Iss 8404, p 8404 (2020)
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic potential in type 2 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605c0fe8eab6e17a23887f9dcbbd9fee
Autor:
Christopher Dunsby, Paul Michael William French, Stephen R. Bloom, Alejandra Tomas, David J. Hodson, Zijian Fang, Philip Pickford, Guy A. Rutter, Sunil Kumar, Johannes Broichhagen, Shiqian Chen, Ben Jones, Ivan R. Corrêa, Tricia Tan, Frederik Görlitz
Publikováno v:
ACS Pharmacology & Translational Science
ACS Pharmacol Transl Sci
ACS Pharmacol Transl Sci
Signal bias and membrane trafficking have recently emerged as important considerations in the therapeutic targeting of the glucagon-like peptide-1 receptor (GLP-1R) in type 2 diabetes and obesity. In the present study, we have evaluated a peptide ser
Autor:
James Minnion, Alejandra Tomas, Philip Pickford, Ben Jones, Guy A. Rutter, Jan Ungewiss, Katja Schoeneberg, Stephen R. Bloom, Maria Lucey
Publikováno v:
bioRxiv
ObjectiveTo determine how pharmacokinetically advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias, trafficking, anti-hyperglycaemic efficacy and appetite suppression.MethodsIn vitro signalling responses were measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedd1c716a085ce9f42a303cde8d8708
https://doi.org/10.1101/855874
https://doi.org/10.1101/855874
Autor:
Paul Johnson, Alejandra Tomas, Stephen R. Bloom, Piero Marchetti, Phoebe C Douzenis, Lorenzo Piemonti, Guy A. Rutter, Domenico Bosco, A. M. James Shapiro, Pauline Chabosseau, Ben Jones, Ivan R. Corrêa, Teresa Buenaventura, N Kanda
Publikováno v:
Diabetes, Vol. 67, No 3 (2018) pp. 385-399
The glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) is a key target for type 2 diabetes (T2D) treatment. Because endocytic trafficking of agonist-bound receptors is one of the most important routes for regulation of receptor signaling, a better und
Autor:
Victoria Salem, Tricia Tan, Alejandra Tomas, David J. Hodson, Johannes Broichhagen, Ben Jones, Shiqian Chen, Ivan R. Corrêa, Stephen R. Bloom, Phil Pickford, Guy A. Rutter, Amaara Marzook, Maria Lucey, Yifan Wang
Publikováno v:
Biochemical Pharmacology
Graphical abstract
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of glucose homeostasis and has been successfully targeted for the treatment of type 2 diabetes. Recently described biased GLP-1R agonists with selective r
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of glucose homeostasis and has been successfully targeted for the treatment of type 2 diabetes. Recently described biased GLP-1R agonists with selective r
Autor:
Hannah Norman, Asuka Inoue, Teresa Buenaventura, Emma Rose McGlone, Zekun Lyu, Stavroula Bitsi, Guy A. Rutter, Andrey S. Klymchenko, William E Laughlin, Affiong I Oqua, Abigail Walker, Alejandra Tomas, Ben Jones, Stephen R. Bloom, Ivan R. Corrêa, Thomas Burgoyne, Aylin Hanyaloglou
The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes and obesity, is known to undergo palmitoylation by covalent ligation of an acyl chain to cysteine 438 in its carboxyl-terminal tail. Work with other GPCRs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec7bf98be3fcb43cd46aa26abfcc903
https://doi.org/10.1101/492496
https://doi.org/10.1101/492496