Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Peter Bergsten"'
Publikováno v:
Environmental Research. 172:127-136
Background In children with obesity, accentuated insulin secretion has been coupled with development of type 2 diabetes mellitus (T2DM). Bisphenol A (BPA) is a chemical with endocrine- and metabolism-disrupting properties which can be measured in a m
Autor:
Peter Bergsten, Hanna Ritzén, Jenny Presto, Hannes Manell, Monica Vilhelmsson, Carolina Gäredal, Anders H. Forslund, Hjalti Kristinsson
Publikováno v:
Diabetes. 67
We have previously reported that insulin and glucagon levels at fasting and during OGTT are increased in obese adolescents as glucose intolerance develops. In adults incretin hormone GIP has been coupled with enhanced glucagon secretion. We hypothesi
Autor:
Maria Koziołkiewicz, Anna Drzazga, Hjalti Kristinsson, Hubert Zatorski, Peter Bergsten, Edyta Gendaszewska-Darmach, Maciej Sałaga
Lysophosphatidylcholine (LPC) is an endogenous ligand for GPR119 receptor, mediating glucose-stimulated insulin secretion (GSIS). We demonstrate that LPC facilitates GSIS in MIN6 pancreatic β-cell line and murine islets of Langerhans by recognizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526a5df1c0dc5bc1ee369f5cc47a4177
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369515
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369515
Autor:
Azazul Islam Chowdhury, Peter Bergsten
Elevated circulating palmitate levels have been connected with type 2 diabetes mellitus. GLP-1 has favorable effects on beta-cells function. The aim was to identify mechanisms for decreased GSIS after long-term palmitate exposure and restoration by G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816ae8615ee3dec8c3118cc92769eb5a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315822
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315822
Publikováno v:
Endocrinology; Vol 154
Free fatty acids (FFAs) have pleiotropic effects on the pancreatic β-cell. Although acute exposure to FFAs stimulates glucose-stimulated insulin secretion (GSIS), prolonged exposure impairs GSIS and causes apoptosis. FFAs exert their effects both vi
Autor:
Anders Forslund, Jing Cen, Hannes Manell, Peter Bergsten, Rasmus Stenlid, Levon Manukyan, Hjalti Kristinsson, Johan Staaf, Iris Ciba
Context:Proglucagon-derived hormones are important for glucose metabolism, but little is known about them in pediatric obesity and type 2 diabetes mellitus (T2DM).Objective:Fasting and postprandial levels of proglucagon-derived peptides glucagon, GLP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ad1b1850ebc39959190edd8c76474
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-292749
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-292749
Autor:
Azazul Islam Chowdhury, Ernest Sargsyan, Jonas Bergquist, Peter Bergsten, Johan Staaf, Anders Forslund, Sarojini J.K.A. Ubhayasekera, Hjalti Kristinsson, Hannes Manell
BACKGROUND: The prevalence of obesity-related diabetes in childhood is increasing and circulating levels of nonesterified fatty acids may constitute a link. Here, the association between palmitate and insulin secretion was investigated in vivo and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aaa997d3020a1085d5af356117a318
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-312661
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-312661
Autor:
Neville H. McClenaghan, Mark Russell, Tania Maffucci, Mark D. Turner, Noel G. Morgan, Aileen King, Catherine Arden, Claire Marriott, Shanta J. Persaud, Adrian J. Bone, Astrid C Hauge-Evans, MustafaY.G. Younis, Christina Reers, Moira Harrison, Peter Bergsten, James Brown, Emma Willoughby, Catriona Kelly, Simon J. Dunmore, Zheng-Liang Zhi, Peter M. Jones
Publikováno v:
Islets. 2:236-239
Laboratory-based research aimed at understanding processes regulating insulin secretion and mechanisms underlying beta-cell dysfunction and loss in diabetes often makes use of rodents, as these processes are in many respects similar between rats/mice
Autor:
Ugo Boggi, Piero Marchetti, Hanna K Nyblom, Marco Bugliani, Eva Fung, Peter Bergsten, Roman A. Zubarev
Publikováno v:
Journal of Proteome Research. 8:5650-5656
Islet dysfunction is a primary cause of developing type 2 diabetes mellitus (T2DM). Events leading to islet failure are still poorly defined due to the complexity of the disease and scarcity of human T2DM islets. The aim of the present study was to i
Autor:
Meftun Ahmed, Peter Bergsten
Publikováno v:
Diabetologia. 48:477-485
The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. Islets were isolated from C57BL/6J