Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ronald L. Hanson"'
Publikováno v:
Tetrahedron: Asymmetry. 17:1589-1602
Previously we have demonstrated the reduction of ethyl diketoester 4 to the corresponding dihydroxy ester 6a by Acinetobacter sp. SC13874. Recently we screened more than 100 cultures for microbial reduction of both the ethyl and t-butyl diketoesters
Autor:
Laporte Thomas L, John M. Wasylyk, Ronald L. Hanson, Ramesh N. Patel, Animesh Goswami, Kishta Katipally, Hyei-Jha Chung, Venkata B. Nanduri
Publikováno v:
Enzyme and Microbial Technology. 28:632-636
Three different biochemical approaches were used for the synthesis of ethyl 5-(S)-hydroxyhexanoate 1 and 5-(S)-hydroxyhexanenitrile 2. In the first approach, ethyl 5-oxo-hexanoate 3 and 5-oxo-hexanenitrile 4 were reduced by Pichia methanolica (SC 161
Autor:
Clyde G. McNamee, Bang-Chi Chen, Ronald L. Hanson, Gus A. Kodersha, Amit Banerjee, Mark D. Schwinden, Ramesh N. Patel, David R. Kronenthal, David B. Brzozowski, Bharat P. Patel, Laszlo J. Szarka
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:2247-2252
L-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and > 99% optical purity by reductive amination of 2-keto-6-hydroxyhexanoic acid using glutamate dehydrogenase from beef liver
Autor:
Laszlo J. Szarka, Amit Banerjee, F. Taha Comezoglu, K. David Mirfakhrae, Ronald L. Hanson, Ramesh N. Patel
Publikováno v:
Tetrahedron: Asymmetry. 5:1925-1934
α-(3-Chloropropyl)-4-fluorobenzenemethanol, a possible intermediate for synthesis of a potential anti-psychotic agent α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol (BMS 181100), was resolved by acetylation using isopropenyl ace
Autor:
David B. Brzozowski, Laszlo J. Szarka, Ronald L. Hanson, Amit Banerjee, Ramesh N. Patel, Clyde G. McNamee
Publikováno v:
Enzyme and Microbial Technology. 15:1014-1021
The key chiral intermediate 3,5-dihydroxy-6-(benzyloxy) hexanoic acid, ethyl ester 2a, was made by the stereoselective microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic acid, ethyl ester 1. Among various microbial cultures evaluated, cell suspe