Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jack Satsangi"'
Publikováno v:
Journal of Crohn's and Colitis. 15:1376-1386
Since the beginning of the pandemic, patients with inflammatory bowel diseases [IBD] have been considered at high risk for infection and complications of COVID-19. IBD patients and patients taking immunosuppressive therapy were excluded from clinical
Autor:
Philip Jenkinson, Mrithula Shivakumar, Gareth-Rhys Jones, Ian D. Arnott, R Grant, Jack Satsangi, Charlie W. Lees, Ruairi Lynch, Nikolas Plevris, F Jagger, William M Brindle, Thomas Manship
Publikováno v:
Inflammatory Bowel Diseases. 27:451-457
Background Intravenous (IV) steroids remain the first-line treatment for patients with acute ulcerative colitis (UC). However, 30% of patients do not respond to steroids, requiring second-line therapy and/or surgery. There are no existing indices tha
Autor:
Sarah Cripps, J Goodhand, Nicholas A Kennedy, Thomas Chapman, Alexandra Kent, Shuvra Ray, Tariq Ahmad, Alissa Walsh, Jack Satsangi, Peter M. Irving, Sailish Honap, Esha Sharma, D Chee, Mehul Patel, James Kennedy
Publikováno v:
Posters.
Introduction Tofacitinib is an oral partially selective Janus kinase inhibitor approved for the treatment of refractory moderate to severe ulcerative colitis (UC). Real-world experience of patients with UC treated with tofacitinib is however limited,
Autor:
Sailish, Honap, Desmond, Chee, Thomas P, Chapman, Mehul, Patel, Alexandra J, Kent, Shuvra, Ray, Esha, Sharma, James, Kennedy, Sarah, Cripps, Alissa, Walsh, James R, Goodhand, Tariq, Ahmad, Jack, Satsangi, Peter M, Irving, Nicholas A, Kennedy, Lucy, Medcalf
Publikováno v:
Journal of Crohn'scolitis. 14(10)
Background Tofacitinib is a partially selective Janus kinase inhibitor approved for the treatment of refractory moderate to severe ulcerative colitis [UC]. We sought to define the effectiveness and adverse effects of tofacitinib in a real-world cohor
Autor:
John A. Snowden, Chris Hawkey, Daniel Hind, Lizzie Swaby, Katie Mellor, Richard Emsley, Laura Mandefield, Ellen Lee, Manuela Badoglio, Emmanuelle Polge, Myriam Labopin, John Gribben, A. Graham Pockley, Gemma A. Foulds, Alan Lobo, Simon Travis, Miles Parkes, Jack Satsangi, Diana Papaioannou, James O. Lindsay, on Behalf of the Autologous Stem Cell Transplantation In Refractory CD - Low Intensity Therapy Evaluation Study Investigators, the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP)
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-14 (2019)
BMC Gastroenterology
2019, ' Autologous stem cell transplantation in refractory Crohn's disease-low intensity therapy evaluation (ASTIClite) : study protocols for a multicentre, randomised controlled trial and observational follow up study ', BMC GASTROENTEROLOGY, vol. 19, no. 1, 82, pp. 82 . https://doi.org/10.1186/s12876-019-0992-2
Snowden, J A, Hawkey, C, Hind, D, Swaby, L, Mellor, K, Emsley, R, Mandefield, L, Lee, E, Badoglio, M, Polge, E, Labopin, M, Gribben, J, Pockley, A G, Foulds, G A, Lobo, A, Travis, S, Parkes, M, Satsangi, J & Papaioannou, D & Lindsay, J O 2019, ' Autologous stem cell transplantation in refractory Crohn's disease-low intensity therapy evaluation (ASTIClite) : study protocols for a multicentre, randomised controlled trial and observational follow up study ', BMC gastroenterology, vol. 19, no. 1, pp. 82 . https://doi.org/10.1186/s12876-019-0992-2
BMC Gastroenterology
2019, ' Autologous stem cell transplantation in refractory Crohn's disease-low intensity therapy evaluation (ASTIClite) : study protocols for a multicentre, randomised controlled trial and observational follow up study ', BMC GASTROENTEROLOGY, vol. 19, no. 1, 82, pp. 82 . https://doi.org/10.1186/s12876-019-0992-2
Snowden, J A, Hawkey, C, Hind, D, Swaby, L, Mellor, K, Emsley, R, Mandefield, L, Lee, E, Badoglio, M, Polge, E, Labopin, M, Gribben, J, Pockley, A G, Foulds, G A, Lobo, A, Travis, S, Parkes, M, Satsangi, J & Papaioannou, D & Lindsay, J O 2019, ' Autologous stem cell transplantation in refractory Crohn's disease-low intensity therapy evaluation (ASTIClite) : study protocols for a multicentre, randomised controlled trial and observational follow up study ', BMC gastroenterology, vol. 19, no. 1, pp. 82 . https://doi.org/10.1186/s12876-019-0992-2
Background\ud \ud Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and significant health care
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428edd83ed68c29b2122e9a146ecd5bb
Autor:
I. D. R. Arnott, Linda Smith, Elaine R. Nimmo, Jack Satsangi, Hazel E. Drummond, Colin L. Noble
Introduction: Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33be18ff20886c2055e1d7f2c868f289
https://doi.org/10.1136/gut.2005.066621
https://doi.org/10.1136/gut.2005.066621
Autor:
Niall Anderson, Linda Smith, Elaine R. Nimmo, Hazel E. Drummond, David C. Wilson, Johan Van Limbergen, Ian D. Arnott, G. Davies, Jack Satsangi, Richard K Russell
Both NOD1/CARD4 and NOD2/CARD15 are intracellular pattern-recognition receptors involved in the innate immune response. Germline NOD2/CARD15 variation has a definite effect on susceptibility to Crohn's disease (CD) and phenotype, although this contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b3266a36fabd6941c1f463d9dc8817
https://ora.ox.ac.uk/objects/uuid:0670a211-d684-45c3-b3f8-61aebe4fdaff
https://ora.ox.ac.uk/objects/uuid:0670a211-d684-45c3-b3f8-61aebe4fdaff
Autor:
Corneliu A. Bodea, Benjamin M. Neale, Stephan Ripke, Mark J. Daly, Bernie Devlin, Kathryn Roeder, Murray Barclay, Laurent Peyrin-Biroulet, Mathias Chamaillard, Jean-Frederick Colombel, Mario Cottone, Anthony Croft, Renata D’Incà, Jonas Halfvarson, Katherine Hanigan, Paul Henderson, Jean-Pierre Hugot, Amir Karban, Nicholas A. Kennedy, Mohammed Azam Khan, Marc Lémann, Arie Levine, Dunecan Massey, Monica Milla, Grant W. Montgomery, Sok Meng Evelyn Ng, Ioannis Oikonomou, Harald Peeters, Deborah D. Proctor, Jean-Francois Rahier, Rebecca Roberts, Paul Rutgeerts, Frank Seibold, Laura Stronati, Kirstin M. Taylor, Leif Törkvist, Kullak Ublick, Johan Van Limbergen, Andre Van Gossum, Morten H. Vatn, Hu Zhang, Wei Zhang, Jane M. Andrews, Peter A. Bampton, Timothy H. Florin, Richard Gearry, Krupa Krishnaprasad, Ian C. Lawrance, Gillian Mahy, Graham Radford-Smith, Rebecca L. Roberts, Lisa A. Simms, Leila Amininijad, Isabelle Cleynen, Olivier Dewit, Denis Franchimont, Michel Georges, Debby Laukens, Emilie Theatre, André Van Gossum, Severine Vermeire, Guy Aumais, Leonard Baidoo, Arthur M. Barrie, Karen Beck, Edmond-Jean Bernard, David G. Binion, Alain Bitton, Steve R. Brant, Judy H. Cho, Albert Cohen, Kenneth Croitoru, Lisa W. Datta, Colette Deslandres, Richard H. Duerr, Debra Dutridge, John Ferguson, Joann Fultz, Philippe Goyette, Gordon R. Greenberg, Talin Haritunians, Gilles Jobin, Seymour Katz, Raymond G. Lahaie, Dermot P. McGovern, Linda Nelson, Sok Meng Ng, Kaida Ning, Pierre Paré, Miguel D. Regueiro, John D. Rioux, Elizabeth Ruggiero, L. Philip Schumm, Marc Schwartz, Regan Scott, Yashoda Sharma, Mark S. Silverberg, Denise Spears, A. Hillary Steinhart, Joanne M. Stempak, Jason M. Swoger, Constantina Tsagarelis, Clarence Zhang, Hongyu Zhao, Jan Aerts, Tariq Ahmad, Hazel Arbury, Anthony Attwood, Adam Auton, Stephen G. Ball, Anthony J. Balmforth, Chris Barnes, Jeffrey C. Barrett, Inês Barroso, Anne Barton, Amanda J. Bennett, Sanjeev Bhaskar, Katarzyna Blaszczyk, John Bowes, Oliver J. Brand, Peter S. Braund, Francesca Bredin, Gerome Breen, Morris J. Brown, Ian N. Bruce, Jaswinder Bull, Oliver S. Burren, John Burton, Jake Byrnes, Sian Caesar, Niall Cardin, Chris M. Clee, Alison J. Coffey, John M.C. Connell, Donald F. Conrad, Jason D. Cooper, Anna F. Dominiczak, Kate Downes, Hazel E. Drummond, Darshna Dudakia, Andrew Dunham, Bernadette Ebbs, Diana Eccles, Sarah Edkins, Cathryn Edwards, Anna Elliot, Paul Emery, David M. Evans, Gareth Evans, Steve Eyre, Anne Farmer, Nicol Ferrier, Edward Flynn, Alistair Forbes, Liz Forty, Jayne A. Franklyn, Timothy M. Frayling, Rachel M. Freathy, Eleni Giannoulatou, Polly Gibbs, Paul Gilbert, Katherine Gordon-Smith, Emma Gray, Elaine Green, Chris J. Groves, Detelina Grozeva, Rhian Gwilliam, Anita Hall, Naomi Hammond, Matt Hardy, Pile Harrison, Neelam Hassanali, Husam Hebaishi, Sarah Hines, Anne Hinks, Graham A. Hitman, Lynne Hocking, Chris Holmes, Eleanor Howard, Philip Howard, Joanna M.M. Howson, Debbie Hughes, Sarah Hunt, John D. Isaacs, Mahim Jain, Derek P. Jewell, Toby Johnson, Jennifer D. Jolley, Ian R. Jones, Lisa A. Jones, George Kirov, Cordelia F. Langford, Hana Lango-Allen, G. Mark Lathrop, James Lee, Kate L. Lee, Charlie Lees, Kevin Lewis, Cecilia M. Lindgren, Meeta Maisuria-Armer, Julian Maller, John Mansfield, Jonathan L. Marchini, Paul Martin, Dunecan C.O. Massey, Wendy L. McArdle, Peter McGuffin, Kirsten E. McLay, Gil McVean, Alex Mentzer, Michael L. Mimmack, Ann E. Morgan, Andrew P. Morris, Craig Mowat, Patricia B. Munroe, Simon Myers, William Newman, Elaine R. Nimmo, Michael C. O’Donovan, Abiodun Onipinla, Nigel R. Ovington, Michael J. Owen, Kimmo Palin, Aarno Palotie, Kirstie Parnell, Richard Pearson, David Pernet, John R.B. Perry, Anne Phillips, Vincent Plagnol, Natalie J. Prescott, Inga Prokopenko, Michael A. Quail, Suzanne Rafelt, Nigel W. Rayner, David M. Reid, Anthony Renwick, Susan M. Ring, Neil Robertson, Samuel Robson, Ellie Russell, David St Clair, Jennifer G. Sambrook, Jeremy D. Sanderson, Stephen J. Sawcer, Helen Schuilenburg, Carol E. Scott, Richard Scott, Sheila Seal, Sue Shaw-Hawkins, Beverley M. Shields, Matthew J. Simmonds, Debbie J. Smyth, Elilan Somaskantharajah, Katarina Spanova, Sophia Steer, Jonathan Stephens, Helen E. Stevens, Kathy Stirrups, Millicent A. Stone, David P. Strachan, Zhan Su, Deborah P.M. Symmons, John R. Thompson, Wendy Thomson, Martin D. Tobin, Mary E. Travers, Clare Turnbull, Damjan Vukcevic, Louise V. Wain, Mark Walker, Neil M. Walker, Chris Wallace, Margaret Warren-Perry, Nicholas A. Watkins, John Webster, Michael N. Weedon, Anthony G. Wilson, Matthew Woodburn, B. Paul Wordsworth, Chris Yau, Allan H. Young, Eleftheria Zeggini, Matthew A. Brown, Paul R. Burton, Mark J. Caulfield, Alastair Compston, Martin Farrall, Stephen C.L. Gough, Alistair S. Hall, Andrew T. Hattersley, Adrian V.S. Hill, Christopher G. Mathew, Marcus Pembrey, Jack Satsangi, Michael R. Stratton, Jane Worthington, Matthew E. Hurles, Audrey Duncanson, Willem H. Ouwehand, Miles Parkes, Nazneen Rahman, John A. Todd, Nilesh J. Samani, Dominic P. Kwiatkowski, Mark I. McCarthy, Nick Craddock, Panos Deloukas, Peter Donnelly, Jenefer M. Blackwell, Elvira Bramon, Juan P. Casas, Aiden Corvin, Janusz Jankowski, Hugh S. Markus, Colin N.A. Palmer, Robert Plomin, Anna Rautanen, Richard C. Trembath, Ananth C. Viswanathan, Nicholas W. Wood, Chris C.A. Spencer, Gavin Band, Céline Bellenguez, Colin Freeman, Garrett Hellenthal, Matti Pirinen, Amy Strange, Hannah Blackburn, Suzannah J. Bumpstead, Serge Dronov, Matthew Gillman, Alagurevathi Jayakumar, Owen T. McCann, Jennifer Liddle, Simon C. Potter, Radhi Ravindrarajah, Michelle Ricketts, Matthew Waller, Paul Weston, Sara Widaa, Pamela Whittaker
Publikováno v:
American journal of human genetics, Vol. 98, no. 5, p. 857-868 (2016)
A. Palotie on työryhmän Int IBD Genetics Consortium jäsen. One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign va
Autor:
Edward V. Loftus, J Petersson, Jack Satsangi, Roopal Thakkar, Dilek Arikan, Geert R. D'Haens, Remo Panaccione, Jasmina Kalabic, Mareike Bereswill, Eva Perotti, Gabriela Alperovich, Walter Reinisch, Anne M. Robinson
Publikováno v:
American journal of gastroenterology, 113(6), 872-882. Springer Nature
OBJECTIVES Real-world, prospective, long-term studies in Crohn’s disease (CD) characterizing adalimumab safety data and lymphoma risk were lacking. We present the final results from the PYRAMID registry, which was designed to rule out a doubling of
Autor:
Ian D. Arnott, F Jagger, Gwo-Tzer Ho, Jack Satsangi, Ruairi Lynch, Thomas Manship, Charlie W. Lees, MissRebecca Grant
Publikováno v:
IBD.
Introduction Intravenous steroids remain the standard first line treatment for patients with acute ulcerative colitis (UC). However, 30% of patients fail to respond and require second line therapies and/or surgery. The purpose of this study was to de