Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Leslie A. Lange"'
Autor:
Luciana B. Vargas, Leslie A. Lange, Kendra Ferrier, François Aguet, Kristin Ardlie, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Thomas W. Blackwell, Jingzhong Ding, Peter Durda, Russell P. Tracy, Yongmei Liu, Kent D. Taylor, W. Craig Johnson, Stephen S. Rich, Jerome I. Rotter, Ethan M. Lange, Iain R. Konigsberg
Publikováno v:
Int J Obes (Lond)
International journal of obesity (2005), vol 47, iss 2
International journal of obesity (2005), vol 47, iss 2
BACKGROUND/OBJECTIVES: Obesity, defined as excessive fat accumulation that represents a health risk, is increasing in adults and children, reaching global epidemic proportions. Body mass index (BMI) correlates with body fat and future health risk, ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df705ac0707d6640bfbfdd95c141ab5
https://europepmc.org/articles/PMC9990473/
https://europepmc.org/articles/PMC9990473/
Autor:
Adolfo Correa, Jai G. Broome, Chunyan Ren, Kari E. North, Nancy L. Heard-Costa, Yao Yao, Brian D. Hobbs, Mary Cushman, Leslie A. Lange, Daniel E. Bauer, Xiuwen Zheng, Braxton D. Mitchell, Yun Li, Quan Sun, Sébastian Méric de Bellefon, Terri H. Beaty, Paul S. de Vries, Ruth J. F. Loos, Adrienne M. Stilp, Albert V. Smith, Paul L. Auer, Deepti Jain, Lifang Hou, Robert C. Kaplan, Jee-Young Moon, Michael Preuss, Stephen S. Rich, Guillaume Lettre, Nicole Soranzo, Eric Boerwinkle, Kousik Kundu, Laura Almasy, Marsha M. Wheeler, Thomas W. Blackwell, Nancy Min, Nicholas L. Smith, Bruce M. Psaty, Lisa R. Yanek, Joanne E. Curran, Stacey Gabriel, Kathleen A. Ryan, Alanna C. Morrison, Lynette Ekunwe, Caitlin P. McHugh, Laura M. Raffield, Adam S. Butterworth, Deborah A. Nickerson, Ravindranath Duggirala, Gonçalo R. Abecasis, John Lane, Hélène Choquet, Andrew D. Johnson, Nauder Faraday, Russell T. Walton, Praveen Surendran, Jennifer A. Brody, Yao Hu, Alexander P. Reiner, Jerome I. Rotter, Donald M. Lloyd-Jones, Cathy C. Laurie, Zhe Wang, Hua Tang, Charles Kooperberg, Eric Jorgenson, Jeffrey R. O'Connell, Shuquan Rao, Nathalie Chami, Rasika A. Mathias, Matthew P. Conomos, Myriam Fornage, Ramachandran S. Vasan, Nathan Pankratz, Joshua P. Lewis, Lewis C. Becker, Benjamin P. Kleinstiver, Cecelia A. Laurie, Ming-Huei Chen, John Blangero
Publikováno v:
Am J Hum Genet
Summary Whole-genome sequencing (WGS), a powerful tool for detecting novel coding and non-coding disease-causing variants, has largely been applied to clinical diagnosis of inherited disorders. Here we leveraged WGS data in up to 62,653 ethnically di
Autor:
George J. Papanicolaou, Peter Durda, Ashley J. Mulford, Russell P. Tracy, Kent D. Taylor, Christopher R. Gignoux, Xiuqing Guo, Cathy C. Laurie, Ryan Schubert, Timothy A. Thornton, Matthew P. Conomos, Leslie A. Lange, Ethan M. Lange, Isabelle Gregga, W. Craig Johnson, Clary B. Clish, Hae Kyung Im, David Van Den Berg, Elaine Cornell, Yongmei Liu, Anna V. Mikhaylova, Tuuli Lappalainen, Jerome I. Rotter, François Aguet, Robert E. Gerszten, Michael H. Cho, Elyse Geoffroy, Heather E. Wheeler, Kristin G. Ardlie, Ani Manichaikul, Stephen S. Rich, Thomas W. Blackwell
Publikováno v:
PloS one, vol 17, iss 2
Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of the genetically regulated proteome for understanding complex trait mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4577e2fbc4d7a18e9bd817541daf0454
https://escholarship.org/uc/item/8x9456z8
https://escholarship.org/uc/item/8x9456z8
Autor:
Jennifer A. Brody, Stephen S. Rich, Bruce M. Psaty, Myriam Fornage, Santiago Romero-Brufau, Genevieve Lyons, Michael Elgart, Daniel Levy, Gina M. Peloso, Henry J. Lin, Laura M. Raffield, Xiuqing Guo, Jerome I. Rotter, Han Chen, Yan Gao, Leslie A. Lange, Tamar Sofer, Donald M. Lloyd-Jones, Paul S. de Vries, Alanna C. Morrison, Susan Redline, Nuzulul Kurniansyah
Polygenic risk scores (PRS) are commonly used to quantify the inherited susceptibility for a given trait. However, the standard PRS fail to account for non-linear and interaction effects between single nucleotide polymorphisms (SNPs). Machine learnin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2500d283209b85dfbb632484f47b1ec3
https://doi.org/10.1101/2021.07.09.21260288
https://doi.org/10.1101/2021.07.09.21260288
Autor:
Winkler C, Mary Cushman, Jeffrey B. Kopp, Lydia H. Pecker, Yang Y, Leslie A. Lange, Amit Patki, Hans Ackerman, Neil A. Zakai, Bryan T. Mott, Marguerite R. Irvin, Rakhi P. Naik, Amy Parker Ruhl, Orlando M. Gutiérrez, Jeffries N
BackgroundAlpha globin gene (HBA)copy number is variable among people of African descent.HBAlimits endothelial nitric oxide signaling and variation in gene copy number could modify kidney disease risk in this population.ObjectiveTo examine the associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa86c1b230ddd124b37691b2718b048
https://doi.org/10.1101/2021.04.01.21254397
https://doi.org/10.1101/2021.04.01.21254397
Autor:
Marju Orho-Melander, Humberto García-Ortiz, Xueling Sim, Amp-T D-Genes, Cheol Joo Park, Gina M. Peloso, Jason Flannick, Brian Tomlinson, Hyun Min Kang, Emilio J. Cordova, Stephen S. Rich, Richard A. Gibbs, Angélica Martínez-Hernández, Lorena Orozco, Harsha Doddapaneni, Lisa R. Yanek, Jiwon Lee, Namrata Gupta, Valeriya Lyssenko, Sohee Han, James B. Meigs, Bong-Jo Kim, Bruce M. Psaty, Leslie S. Emery, Kerrin S. Small, Pradeep Natarajan, May E. Montasser, Christian Gieger, Sharon L.R. Kardia, Sarah C. Nelson, Craig L. Hanis, Heikki A. Koistinen, María Elena González-Villalpando, Edmund Chan, Michael Y. Tsai, Benjamin Glaser, Thomas Meitinger, Matthew J. Bown, Mariaelisa Graff, John Danesh, Sekar Kathiresan, Tiinamaija Tuomi, Ramachandran S. Vasan, Gil Atzmon, Alyna T. Khan, Diego Ardissino, Yii-Der Ida Chen, David Zhang, Rob M. van Dam, Wendy S. Post, Barry I. Freedman, D. C. Rao, Michael Preuss, Donna M. Lehman, L. Adrienne Cupples, Colin N. A. Palmer, Claudia H. T. Tam, Hortensia Moreno-Macías, Markku Laakso, Peter Dornbos, Teresa Tusié-Luna, Stella Aslibekyan, Marguerite R. Irvin, Daniel J. Rader, Jee-Young Moon, Eimear E. Kenny, Lisa W. Martin, Jennifer A. Brody, Amit Khera, Erwin P. Bottinger, Sarah E. Graham, Myriam Fornage, Ruth McPherson, Nancy L. Heard-Costa, Michael Boehnke, Clicerio Gonzalez, Ryan W. Kim, Yi-Cheng Chang, Peter M. Nilsson, Yik Ying Teo, Robert Sladek, Cristen J. Willer, Fei Fei Wang, Donna K. Arnett, Mark Chaffin, Karine A. Viaud Martinez, Alanna C. Morrison, Leslie A. Lange, Ravindranath Duggirala, Donna M. Muzny, Kent D. Taylor, Niels Grarup, Soren Germer, Patricia A. Peyser, Brian E. Cade, Lewis C. Becker, Steven A. Lubitz, Nicholette D. Palmer, Susan K. Dutcher, Ronald C.W. Ma, Xuenan Mi, Xiuqing Guo, Hugh Watkins, Eric Boerwinkle, Qibin Qi, Johanna Kuusisto, Christie M. Ballantyne, Tanika N. Kelly, Rajiv Chowdhury, Elvia Mendoza-Caamal, Wing-Yee So, Tien Yin Wong, Torben Hansen, Cecilia Contreras-Cubas, Jeong-Sun Seo, Mi Yeong Hwang, Daekwan Seo, Dajiang J. Liu, Cristina Revilla-Monsalve, Paul S. de Vries, Daniel R. Witte, Yi-Jen Hung, Olle Melander, Karen L. Mohlke, Lucinda Antonacci-Fulton, Francisco Barajas-Olmos, Soo Heon Kwak, Daniel E. Weeks, Claudia Schurmann, Ginger A. Metcalf, Young-Jin Kim, Adrienne M. Stilp, Lori L. Bonnycastle, John Blangero, Ralph A. DeFronzo, Donald W. Bowden, Rasika A. Mathias, Oluf Pedersen, Rozenn N. Lemaitre, Stephen T. McGarvey, Heribert Schunkert, Jaakko Tuomilehto, Farook Thameem, Valentin Fuster, Joshua C. Bis, George Hindy, Allan Linneberg, James G. Wilson, Kyong Soo Park, Sergio A. Islas-Andrade, Ching-Yu Cheng, Won Jung Choi, Minxian X. Wang, Xuzhi Wang, Adolfo Correa, Jai G. Broome, Gail P. Jarvik, Alexander P. Reiner, E. Shyong Tai, Juyoung Lee, Mark I. McCarthy, Nilesh J. Samani, Susan Redline, Carlos A. Aguilar-Salinas, Jerome I. Rotter, Ma. Eugenia Garay-Sevilla, Jiang He, Patrick T. Ellinor, Joseph Park, Joanne E. Curran, Nir Barzilai, Federico Centeno-Cruz, Seonwook Lee, Lawrence F. Bielak, Jianjun Liu, Charles Kooperberg, Juan M. Peralta, Jose C. Florez, Leif Groop, Noël P. Burtt, Margaret Sunitha Selvaraj, Jeffrey R. O'Connell, Ruth J. F. Loos
Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency170,000 individuals f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cffcbe73ed87d1953f10593c831399
https://doi.org/10.1101/2020.12.22.423783
https://doi.org/10.1101/2020.12.22.423783
Autor:
Paul L. Auer, Laura Almasy, Jerome I. Rotter, Nancy Min, Lisa R. Yanek, Shuquan Rao, Hua Tang, Zhe Wang, Stacey Gabriel, Jee-Young Moon, Nancy L. Heard-Costa, Adam S. Butterworth, Ravindranath Duggirala, Cathy C. Laurie, Hélène Choquet, Ruth J. F. Loos, Alanna C. Morrison, Eric Jorgenson, Charles Kooperberg, Rasika A. Mathias, Laura M. Raffield, Nicholas L. Smith, Andrew D. Johnson, Matthew P. Conomos, Lynette Ekunwe, Donald M. Lloyd-Jones, Gonçalo R. Abecasis, Robert C. Kaplan, Myriam Fornage, Daniel E. Bauer, Nathalie Chami, Lewis C. Becker, Leslie A. Lange, Ming-Huei Chen, Brian D. Hobbs, Paul S. de Vries, Terri H. Beaty, Cecelia A. Laurie, Eric Boerwinkle, Michael Preuss, Adrienne M. Stilp, Jeffrey R. O'Connell, Kousik Kundu, Joanne E. Curran, Mary Cushman, Kari E. North, Xiuwen Zheng, John Blangero, Sébastian Méric de Bellefon, Ramachandran S. Vasan, Nathan Pankratz, Praveen Surendran, Joshua P. Lewis, Kathleen A. Ryan, Jennifer A. Brody, Deepti Jain, Braxton D. Mitchell, Marsha M. Wheeler, Lifang Hou, Deborah A. Nickerson, Guillaume Lettre, Alexander P. Reiner, Albert V. Smith, Stephen S. Rich, Nicole Soranzo, Adolfo Correa, Jai G. Broome, Nauder Faraday, Thomas W. Blackwell, Bruce M. Psaty, Quan Sun, Yun Li, Caitlin P. McHugh, Yao Hu, John Lane
Whole genome sequencing (WGS), a powerful tool for detecting novel coding and non-coding disease-causing variants, has largely been applied to clinical diagnosis of inherited disorders. Here we leveraged WGS data in up to 62,653 ethnically diverse pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740854b9674d9c60813159f3acb4cc59
https://doi.org/10.1101/2020.12.09.20246736
https://doi.org/10.1101/2020.12.09.20246736
Autor:
Namrata Gupta, Peter Durda, Elizabeth C. Oelsner, Martha L. Daviglus, Martin D. Tobin, James G. Wilson, Liana K. Preudhomme, Laura R. Loehr, Ingo Ruczinski, Pallavi Balte, Ramachandran S. Vasan, R. Graham Barr, Phuwanat Sakornsakolpat, Stephanie J. London, Robert M. Reed, Elaine Cornell, Josée Dupuis, Dandi Qiao, Dmitry Prokopenko, Russell P. Tracy, Alanna C. Morrison, Robert C. Kaplan, Cathy C. Laurie, Sina A. Gharib, Donna M. Muzny, Kent D. Taylor, Cecelia A. Laurie, Wonji Kim, Stephen S. Rich, Brian E. Cade, Kristin M. Burkart, Tamar Sofer, George T. O'Connor, Chiara Batini, Louise V. Wain, Leslie A. Lange, Ani Manichaikul, Susan Redline, Yanlin Ma, Bruce M. Psaty, Xutong Zhao, Yongmei Liu, Chaojie Yang, Edwin K. Silverman, David J. Vandenberg, Deborah A. Nickerson, George J. Papanicolaou, Bing Yu, L. Adrienne Cupples, Kathleen C. Barnes, François Aguet, Silva Kasela, Stacey Gabriel, Kristin G. Ardlie, Xiuqing Guo, Gonçalo R. Abecasis, Shannon Dugan-Perez, Harshavardhan Doddapaneni, Jerome I. Rotter, Ginger A. Metcalf, W. Craig Johnson, Michelle Daya, Nick Shrine, Sarah A Gagliano Taliun, Traci M. Bartz, Jiwon Lee, Deepti Jain, Tuuli Lappalainen, Michael H. Cho
Publikováno v:
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497 participan
Autor:
Ryan W. Kim, Daekwan Seo, Braxton D. Mitchell, Karine A. Viaud-Martinez, Peter Durda, Adolfo Correa, Stephen S. Rich, Zeineen Momin, Russell P. Bowler, Laura M. Raffield, Martin G. Larson, Josée Dupuis, Cecelia A. Laurie, Kathleen A. Ryan, Lisa R. Yanek, Jiwon Lee, Russell P. Tracy, Stephanie M. Gogarten, Xihong Lin, Donna M. Muzny, Jerome I. Rotter, Cassandra N. Spracklen, Biqi Wang, Brian E. Cade, Leslie A. Lange, Won Jung Choi, Alejandro P. Comellas, Pedro Cruz, Joshua C. Bis, Linda M. Polfus, Apoorva K Iyengar, Yun Li, Nathan Pankratz, Joshua P. Lewis, Shabnam Salimi, Seonwook Lee, Emelia J. Benjamin, Cheol Joo Park, Ginger A. Metcalf, Lue Ping Zhao, Harsha Doddapaneni, Xue Zhong, Paul L. Auer, Alexander P. Reiner, Brian G. Kral, Madeline H. Kowalski, Sheila M. Gaynor, Bingshan Li, Deepti Jain, Karen L. Mohlke
Publikováno v:
Am J Hum Genet
Whole-genome sequencing (WGS) can improve assessment of low-frequency and rare variants, particularly in non-European populations that have been underrepresented in existing genomic studies. The genetic determinants of C-reactive protein (CRP), a bio
Autor:
Ravi Kalhan, R. Graham Barr, Patricia A. Cassano, Yiyi Zhang, Laura R. Loehr, Andrew E. Moran, Joseph E. Schwartz, Richard A. Kronmal, Aaron R. Folsom, Leslie A. Lange, Pallavi Balte, Fawn Yeh, Robert C. Kaplan, John L. Hankinson, Anne B. Newman, Stanford Mwasongwe, Ana Navas Acien, Paul L. Enright, Sachin Yende, David Couper, Stephanie J. London, Lewis J. Smith, George T. O'Connor, David R. Jacobs, Wendy B. White, Elizabeth C. Oelsner
Publikováno v:
American Journal of Epidemiology. 187:2265-2278
Chronic lower respiratory diseases (CLRDs) are the fourth leading cause of death in the United States. To support investigations into CLRD risk determinants and new approaches to primary prevention, we aimed to harmonize and pool respiratory data fro