Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dajiang. J. Liu"'
BackgroundNatural killer (NK) cells represent a critical component of the innate immune system’s response against cancer and viral infections, among other diseases. To distinguish healthy host cells from infected or tumor cells, killer immunoglobul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017cb1c7a4a9526cd40115f42ccbd5f2
https://doi.org/10.1101/2021.09.02.458787
https://doi.org/10.1101/2021.09.02.458787
Autor:
Laura Carrel, Marisa Englebright, Xiaowei Zhan, Dajiang J. Liu, Renan Sauteraud, Jesica James, Fang Chen, Jill M. Stahl
Publikováno v:
Genome research. 31(9)
The X Chromosome plays an important role in human development and disease. However, functional genomic and disease association studies of X genes greatly lag behind autosomal gene studies, in part owing to the unique biology of X-Chromosome inactivat
Autor:
Marju Orho-Melander, Humberto García-Ortiz, Xueling Sim, Amp-T D-Genes, Cheol Joo Park, Gina M. Peloso, Jason Flannick, Brian Tomlinson, Hyun Min Kang, Emilio J. Cordova, Stephen S. Rich, Richard A. Gibbs, Angélica Martínez-Hernández, Lorena Orozco, Harsha Doddapaneni, Lisa R. Yanek, Jiwon Lee, Namrata Gupta, Valeriya Lyssenko, Sohee Han, James B. Meigs, Bong-Jo Kim, Bruce M. Psaty, Leslie S. Emery, Kerrin S. Small, Pradeep Natarajan, May E. Montasser, Christian Gieger, Sharon L.R. Kardia, Sarah C. Nelson, Craig L. Hanis, Heikki A. Koistinen, María Elena González-Villalpando, Edmund Chan, Michael Y. Tsai, Benjamin Glaser, Thomas Meitinger, Matthew J. Bown, Mariaelisa Graff, John Danesh, Sekar Kathiresan, Tiinamaija Tuomi, Ramachandran S. Vasan, Gil Atzmon, Alyna T. Khan, Diego Ardissino, Yii-Der Ida Chen, David Zhang, Rob M. van Dam, Wendy S. Post, Barry I. Freedman, D. C. Rao, Michael Preuss, Donna M. Lehman, L. Adrienne Cupples, Colin N. A. Palmer, Claudia H. T. Tam, Hortensia Moreno-Macías, Markku Laakso, Peter Dornbos, Teresa Tusié-Luna, Stella Aslibekyan, Marguerite R. Irvin, Daniel J. Rader, Jee-Young Moon, Eimear E. Kenny, Lisa W. Martin, Jennifer A. Brody, Amit Khera, Erwin P. Bottinger, Sarah E. Graham, Myriam Fornage, Ruth McPherson, Nancy L. Heard-Costa, Michael Boehnke, Clicerio Gonzalez, Ryan W. Kim, Yi-Cheng Chang, Peter M. Nilsson, Yik Ying Teo, Robert Sladek, Cristen J. Willer, Fei Fei Wang, Donna K. Arnett, Mark Chaffin, Karine A. Viaud Martinez, Alanna C. Morrison, Leslie A. Lange, Ravindranath Duggirala, Donna M. Muzny, Kent D. Taylor, Niels Grarup, Soren Germer, Patricia A. Peyser, Brian E. Cade, Lewis C. Becker, Steven A. Lubitz, Nicholette D. Palmer, Susan K. Dutcher, Ronald C.W. Ma, Xuenan Mi, Xiuqing Guo, Hugh Watkins, Eric Boerwinkle, Qibin Qi, Johanna Kuusisto, Christie M. Ballantyne, Tanika N. Kelly, Rajiv Chowdhury, Elvia Mendoza-Caamal, Wing-Yee So, Tien Yin Wong, Torben Hansen, Cecilia Contreras-Cubas, Jeong-Sun Seo, Mi Yeong Hwang, Daekwan Seo, Dajiang J. Liu, Cristina Revilla-Monsalve, Paul S. de Vries, Daniel R. Witte, Yi-Jen Hung, Olle Melander, Karen L. Mohlke, Lucinda Antonacci-Fulton, Francisco Barajas-Olmos, Soo Heon Kwak, Daniel E. Weeks, Claudia Schurmann, Ginger A. Metcalf, Young-Jin Kim, Adrienne M. Stilp, Lori L. Bonnycastle, John Blangero, Ralph A. DeFronzo, Donald W. Bowden, Rasika A. Mathias, Oluf Pedersen, Rozenn N. Lemaitre, Stephen T. McGarvey, Heribert Schunkert, Jaakko Tuomilehto, Farook Thameem, Valentin Fuster, Joshua C. Bis, George Hindy, Allan Linneberg, James G. Wilson, Kyong Soo Park, Sergio A. Islas-Andrade, Ching-Yu Cheng, Won Jung Choi, Minxian X. Wang, Xuzhi Wang, Adolfo Correa, Jai G. Broome, Gail P. Jarvik, Alexander P. Reiner, E. Shyong Tai, Juyoung Lee, Mark I. McCarthy, Nilesh J. Samani, Susan Redline, Carlos A. Aguilar-Salinas, Jerome I. Rotter, Ma. Eugenia Garay-Sevilla, Jiang He, Patrick T. Ellinor, Joseph Park, Joanne E. Curran, Nir Barzilai, Federico Centeno-Cruz, Seonwook Lee, Lawrence F. Bielak, Jianjun Liu, Charles Kooperberg, Juan M. Peralta, Jose C. Florez, Leif Groop, Noël P. Burtt, Margaret Sunitha Selvaraj, Jeffrey R. O'Connell, Ruth J. F. Loos
Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency170,000 individuals f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cffcbe73ed87d1953f10593c831399
https://doi.org/10.1101/2020.12.22.423783
https://doi.org/10.1101/2020.12.22.423783
The HFE protein is involved in iron metabolism. There are two (H63D and C282Y) HFE polymorphisms. These HFE polymorphisms have been associated with increased risk in a number of cancers. Previously, we reported gender affects H63D or C282Y glioblasto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c644119aedfbdd85d4b6f62e9154f3
https://europepmc.org/articles/PMC4638759/
https://europepmc.org/articles/PMC4638759/
Autor:
Suzanne M. Leal, Dajiang J. Liu
Publikováno v:
European Journal of Human Genetics. 20:449-456
For most complex trait association studies using next-generation sequencing, in addition to the primary phenotype of interest, many clinically important secondary traits are also available, which can be analyzed to map susceptibility genes. Owing to
Autor:
Dajiang J. Liu, Suzanne M. Leal
Publikováno v:
Assessing Rare Variation in Complex Traits ISBN: 9781493928231
Large-scale sequence-based association analysis is a powerful approach to identify rare variants involved in complex trait etiologies. Confirmation of significant findings in stage 1 through replication in an independent stage 2 sample is necessary t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5683bb3957839940972e29cf41d202f3
https://doi.org/10.1007/978-1-4939-2824-8_14
https://doi.org/10.1007/978-1-4939-2824-8_14
Autor:
Paul L. Auer, Ruth McPherson, Matthew Zawistowski, Dajiang J. Liu, Anuj Goel, Shuang Feng, Kristian Hveem, Hugh Watkins, Cristen J. Willer, Gonçalo R. Abecasis, Marju Orho-Melander, Martin Farrall, Gina M. Peloso, Majid Nikpay, Oddgeir L. Holmen, Sekar Kathiresan, Ulrike Peters, Olle Melander, He Zhang, Xiaowei Zhan, Charles Kooperberg
Publikováno v:
Nature Genetics
Nature genetics
Nature genetics
The majority of reported complex disease associations for common genetic variants have been identified through meta-analysis, a powerful approach that enables the use of large sample sizes while protecting against common artifacts due to population s
Autor:
Suzanne M. Leal, Dajiang J. Liu
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 6, Iss 10, p e1001156 (2010)
PLoS Genetics, Vol 6, Iss 10, p e1001156 (2010)
There is solid evidence that rare variants contribute to complex disease etiology. Next-generation sequencing technologies make it possible to uncover rare variants within candidate genes, exomes, and genomes. Working in a novel framework, the kernel
Autor:
Dajiang J. Liu, Suzanne M. Leal
Publikováno v:
The American Journal of Human Genetics. (6):790-801
There is solid evidence that complex traits can be caused by rare variants. Next-generation sequencing technologies are powerful tools for mapping rare variants. Confirmation of significant findings in stage 1 through replication in an independent st