Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Liana Adam"'
Autor:
Liana Adam, Lauren Marquis, Woonyoung Choi, David J. McConkey, Michael B. Williams, Frances M Martin, Ashish M. Kamat, Arlene O. Siefker-Radtke, Jay B. Shah, Aditi Das, Robert S. Svatek, Colin P.N. Dinney
Publikováno v:
Cancer and Metastasis Reviews. 28:335-344
Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increased invasion and migration. At the molecular level, EM
Autor:
Mark F. Munsell, Ameeta Arora, Marissa Shrader, David J. McConkey, Liana Adam, Teruo Inamoto, Colin P.N. Dinney, Xifeng Wu, Arlene O. Siefker-Radtke, Gordon A. Brown, Dan Theodorescu, Peter C. Black, Menashe Bar-Eli
Publikováno v:
Clinical Cancer Research. 14:1478-1486
Purpose: Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of urothelial carcinoma, but a clinical response can be expected in only a small proportion of patients. The aim of this study was to define molecular markers
Autor:
Menashe Bar-Eli, Colin P.N. Dinney, David J. McConkey, Maria Simona Pino, Laura M. Lashinger, Liana Adam, Marissa Shrader
Publikováno v:
Cancer Research. 67:1430-1435
In a previous study, we found that the small-molecule epidermal growth factor receptor (EGFR) inhibitor gefitinib (ZD1839, Iressa) blocked cell proliferation at biologically relevant concentrations in approximately one third (6 of 17) of human bladde
Autor:
Maria Simona Pino, Liana Adam, Marissa Shrader, David J. McConkey, Colin P.N. Dinney, Peter McL. Black, Gordon A. Brown, Menahse Bar-Eli
Publikováno v:
Molecular Cancer Therapeutics. 6:277-285
We characterized the effects of the small molecule epidermal growth factor receptor (EGFR) inhibitor gefitinib (ZD1839, Iressa) on cell proliferation in a panel of 17 human bladder cancer cell lines. Gefitinib inhibited DNA synthesis in a concentrati
Autor:
Liana Adam, Menashe Bar-Eli, Gordon A. Brown, Alan J. Diehl, Colin P.N. Dinney, David J. McConkey, Wassim Kassouf
Publikováno v:
Cancer Research. 65:10524-10535
Activation of the epidermal growth factor receptor (EGFR) and downstream signaling pathways, such as phosphatidylinositol-3 kinase/Akt and Ras/mitogen-activated protein kinase (MAPK), have been implicated in causing resistance to EGFR-targeted therap
Autor:
Ameeta Arora, Liana Adam, Menashe Bar-Eli, Peter C. Black, Teruo Inamoto, Wassim Kassouf, David Gallagher, David J. McConkey, Gordon A. Brown, Mark F. Munsell, Colin P.N. Dinney
Publikováno v:
The Journal of urology. 185(2)
Human bladder cancer cells resistant to anti-epidermal growth factor receptor therapy often co-express platelet-derived growth factor receptor-β. We determined whether there is functional crosstalk between epidermal growth factor receptor and platel