Zobrazeno 1 - 10
of 23
pro vyhledávání: '"D. Tew"'
Autor:
Wei Chen, Lauren E. Ball, Shikhar Mehrotra, Danyelle M. Townsend, John Culpepper, Haiming Jiang, Jie Zhang, Zhi-Wei Ye, Anna Blumental-Perry, Kenneth D. Tew
Publikováno v:
Free Radic Biol Med
Multiple myeloma (MM) cells have high rates of secretion of proteins rich in disulfide bonds and depend upon compartmentalized redox balance for accurate protein folding. The proteasome inhibitor bortezomib (Btz) is a successful frontline treatment f
Autor:
Stephen P. Ethier, Kenneth D. Tew, Aim in Yang, Gavin Y. Wang, Shenghui Qin, Bradley A. Schulte
Publikováno v:
Cancer Research. 77:6641-6650
There is mounting evidence that cancer stem-like cells (CSC) are selectively enriched in residual tumors after anticancer therapies, which may account for tumor recurrence and metastasis by regenerating new tumors. Thus, there is a critical need to d
Autor:
Annamarie C. Dalton, Lauren E. Ball, Jennifer R. Bethard, Zhi-Wei Ye, Leilei Zhang, Ann-Marie Broome, Yu-Lin Jiang, Jie Zhang, Gavin Y. Wang, Kenneth D. Tew, Yefim Manevich, Danyelle M. Townsend
ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that are naturally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b63bd794e7bb756adf07c0f900e490
https://europepmc.org/articles/PMC6697583/
https://europepmc.org/articles/PMC6697583/
Autor:
Kenneth D. Tew
Publikováno v:
Cancer Research. 76:7-9
The importance of thiol-mediated detoxification of anticancer drugs that produce toxic electrophiles has been of considerable interest to many investigators. Glutathione and glutathione S-transferases (GST) are the focus of much attention in characte
Autor:
Mika Araki, Yuko Shishido, Elias S.J. Arnér, Marcus Cebula, Astrid Ottosson-Wadlund, Danyelle M. Townsend, Jie Zhang, Hisao Saneyoshi, Guido R.M.M. Haenen, Katarina Johansson, Kenneth D. Tew, Marie-José Drittij-Reijnders, Yoshihiro Ito, Philippe Lambin, Hiroshi Abe, Ralf Morgenstern, Marike W. van Gisbergen, Ludwig Dubois
Publikováno v:
Molecular Pharmaceutics, 13(6), 2010-2025. American Chemical Society
Glutathione transferases (GSTs) are often overexpressed in tumors and frequently correlated to bad prognosis and resistance against a number of different anticancer drugs. To selectively target these cells and to overcome this resistance we previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f36a5c4067f31975bba668173dbcc54
https://cris.maastrichtuniversity.nl/en/publications/0079af67-8c39-4262-85fa-ddbd005aa880
https://cris.maastrichtuniversity.nl/en/publications/0079af67-8c39-4262-85fa-ddbd005aa880
Publikováno v:
Expert Opinion on Therapeutic Targets. 12:491-504
Overexpression of ATP-binding cassette (ABC) transporters is a major adaptive advantage used by tumor cells to evade the accumulation of cytotoxic agents. ABCA2, a transporter highly expressed in the cells of the nervous and haematopoetic systems, is
Publikováno v:
Biomedicine & Pharmacotherapy. 60:587-592
ATP-binding cassette (ABC) transporters are a family of proteins that translocate molecules across cellular membranes. Substrates can include lipids, cholesterol and drugs. Mutations in ABC transporter genes can cause human pathologies and drug resis
Publikováno v:
Oncogene. 25:1639-1648
The super family of glutathione S-transferases (GSTs) is composed of multiple isozymes with significant evidence of functional polymorphic variation. Over the last three decades, data from cancer studies have linked aberrant expression of GST isozyme
Autor:
Guy Millot, Philippe Denoulet, Fabien Calvo, Marie-Pierre Podgorniak, Arlette Fellous, Suleeporn Sangrajrang, Kenneth D. Tew, Roger Tatoud
Publikováno v:
International Journal of Cancer. 77:626-631
Estramustine (EM) is an anti-microtubule drug used in the treatment of hormone-refractory advanced prostate cancer. Since microtubules are the targets for EM cytotoxicity, we investigated the effects of EM on the microtubule-associated protein tau to
Autor:
M.L. O'Brien, Kenneth D. Tew
Publikováno v:
European Journal of Cancer. 32:967-978
INTRODUCTION THE DEVELOPMENT of resistance to chemotherapeutic agents, at concentrations which were once effective for treatment, is a major obstacle in the clinical treatment of cancers. Several mechanisms have been described that mediate such resis