Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Karel Hählen"'
Autor:
A H Loonen, Christian M. Zwaan, Bianca F. Goemans, Dirk Reinhardt, Karel Hählen, Gertjan J.L. Kaspers, Amy Harlow, Brenda Gibson, Ursula Creutzig, Michael Heinrich
Publikováno v:
Blood, 106(10), 3532-3537. American Society of Hematology
Goemans, B F, Zwaan, C M, Harlow, A, Loonen, A H, Gibson, B E S, Hählen, K, Reinhardt, D, Creutzig, U, Heinrich, M C & Kaspers, G J L 2005, ' In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib : Identification of T-cell ALL and FAB M5 AML as the most sensitive subsets ', Blood, vol. 106, no. 10, pp. 3532-3537 . https://doi.org/10.1182/blood-2005-04-1640
Goemans, B F, Zwaan, C M, Harlow, A, Loonen, A H, Gibson, B E S, Hählen, K, Reinhardt, D, Creutzig, U, Heinrich, M C & Kaspers, G J L 2005, ' In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib : Identification of T-cell ALL and FAB M5 AML as the most sensitive subsets ', Blood, vol. 106, no. 10, pp. 3532-3537 . https://doi.org/10.1182/blood-2005-04-1640
Although the prognosis of pediatric leukemias has improved considerably, many patients still have relapses. Tipifarnib, a farnesyl transferase inhibitor (FTI), was developed to target malignancies with activated RAS, including leukemia. We tested 52
Autor:
Martin Zimmermann, Jerald P. Radich, Leonhard Munske, Soheil Meshinchi, Dirk Reinhardt, Karel Hählen, Frank Griesinger, Rob Pieters, Jochen Harbott, Christian M. Zwaan, D. R. Huismans, Gertjan J.L. Kaspers, Martina Podleschny, Ursula Creutzig, Anjo J.P. Veerman
Publikováno v:
Blood, 102(7), 2387-2394. American Society of Hematology
Zwaan, C M, Meshinchi, S, Radich, J P, Veerman, A J P, Huismans, D R, Munske, L, Podleschny, M, Hählen, K, Pieters, R, Zimmermann, M, Reinhardt, D, Harbott, J, Creutzig, U, Kaspers, G J L & Griesinger, F 2003, ' FLT3 internal tandem duplication in 234 children with acute myeloid leukemia : Prognostic significance and relation to cellular drug resistance ', Blood, vol. 102, no. 7, pp. 2387-2394 . https://doi.org/10.1182/blood-2002-12-3627
Blood, 102, 2387-2394. American Society of Hematology
Zwaan, C M, Meshinchi, S, Radich, J P, Veerman, A J P, Huismans, D R, Munske, L, Podleschny, M, Hählen, K, Pieters, R, Zimmermann, M, Reinhardt, D, Harbott, J, Creutzig, U, Kaspers, G J L & Griesinger, F 2003, ' FLT3 internal tandem duplication in 234 children with acute myeloid leukemia : Prognostic significance and relation to cellular drug resistance ', Blood, vol. 102, no. 7, pp. 2387-2394 . https://doi.org/10.1182/blood-2002-12-3627
Blood, 102, 2387-2394. American Society of Hematology
FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells. FLT3 internal tandem duplications (FLT3/ITDs) are reported in acute myeloid leukemia (AML) and predict poor clinical outcome. We found F
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities
Autor:
R. Släter, Anjo J.P. Veerman, Martin Zimmermann, Rob Pieters, Karel Hählen, D. R. Huismans, Jochen Harbott, Gertjan J.L. Kaspers, Christian M. Zwaan, U. Creutzig
Publikováno v:
Blood, 100, 3352-3360. American Society of Hematology
Blood, 100(9), 3352-3360. American Society of Hematology
Zwaan, C M, Kaspers, G J L, Pieters, R, Hählen, K, Huismans, D R, Zimmermann, M, Harbott, J, Slater, R M, Creutzig, U & Veerman, A J P 2002, ' Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities ', Blood, vol. 100, no. 9, pp. 3352-3360 . https://doi.org/10.1182/blood.V100.9.3352
Blood, 100(9), 3352-3360. American Society of Hematology
Zwaan, C M, Kaspers, G J L, Pieters, R, Hählen, K, Huismans, D R, Zimmermann, M, Harbott, J, Slater, R M, Creutzig, U & Veerman, A J P 2002, ' Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities ', Blood, vol. 100, no. 9, pp. 3352-3360 . https://doi.org/10.1182/blood.V100.9.3352
Specific cytogenetic abnormalities predict prognosis in childhood acute myeloid leukemia (AML). However, it is unknown why they are predictive and whether this is related to drug resistance. We previously reported that Down syndrome (DS) AML was asso
Autor:
A. E. J. Duyn, A. J. P. Veerman, C. H. Van Zantwijk, Gertjan J.L. Kaspers, Karel Hählen, Rob Pieters, G. J. Broekema
Publikováno v:
Annals of Hematology, 78, 163-171. Springer-Verlag
Annals of Hematology, 78(4), 163-171. Springer Verlag
Duyn, A E J, Kaspers, G J L, Pieters, R, Van Zantwijk, C H, Broekema, G J, Hählen, K & Veerman, A J P 1999, ' Effects of interleukin 3, interleukin 7, and B-cell growth factor on proliferation and drug resistance in vitro in childhood acute lymphoblastic leukemia ', Annals of Hematology, vol. 78, no. 4, pp. 163-171 . https://doi.org/10.1007/s002770050495
Annals of Hematology, 78(4), 163-171. Springer Verlag
Duyn, A E J, Kaspers, G J L, Pieters, R, Van Zantwijk, C H, Broekema, G J, Hählen, K & Veerman, A J P 1999, ' Effects of interleukin 3, interleukin 7, and B-cell growth factor on proliferation and drug resistance in vitro in childhood acute lymphoblastic leukemia ', Annals of Hematology, vol. 78, no. 4, pp. 163-171 . https://doi.org/10.1007/s002770050495
Growth factors have been reported to enhance the cytotoxicity of anticancer agents. In our study we investigated the capacities of interleukin 3 (IL-3), interleukin 7 (IL-7), low-molecular-weight B-cell growth factor (Imw-BCGF), and IL-3 + 7 to induc
Autor:
D. R. Huismans, A. H. Loonen, Rob Pieters, Karel Hählen, A. J. P. Veerman, G.J. Peters, E. R. Van Wering, A. van der Does-van den Berg
Publikováno v:
Leukemia Research. 16:873-880
Ecto-5'-nucleotidase (ecto-5'NT) catalyzes the extracellular dephosphorylation of nucleotides like IMP. Cytoplasmic 5'NT (cyto-5'NT) and non-specific (e.g. acid- and alkaline) phosphatases (AP) regulate the intracellular degradation of nucleotides. H
Autor:
Karel Hählen, Rob Pieters, G.J. Peters, E. R. Van Wering, A. J. P. Veerman, D. R. Huismans, A. H. Loonen, A. van der Does-van den Berg
Publikováno v:
International Journal of Cancer. 51:213-217
Decreased activity of hypoxanthine-guanine phosphoribosyl-transferase (HGPRT), responsible for the conversion of 6-mercaptopurine and 6-thioguanine (6-TG) to their cytotoxic nucleotides, may cause resistance to these thiopurines in experimental leuke
Autor:
G. J. Broekema, A. H. Loonen, M. W. Heyenbrok, Rob Pieters, D. R. Huismans, Karel Hählen, M. W.J. Dirven, Anjo J.P. Veerman
Publikováno v:
Blood. 76:2327-2336
The knowledge about drug resistance in childhood leukemias and acute lymphoblastic leukemia (ALL) in general is limited. This is because of the lack of a suitable in vitro drug sensitivity assay, which is in part due to low in vitro ALL cell survival
Autor:
Elisabeth R. van Wering, A H Loonen, Guenter Henze, Anjo J.P. Veerman, Gertjan J.L. Kaspers, Karel Hählen, Jelle J.M. Wijnands, Arend von Stackelberg, Reinhard Hartmann, Robrecht Pieters, L. Huismans
Publikováno v:
European Journal of Cancer, 41(9), 1300-1303. Pergamon
European Journal of Cancer, 41(9), 1300-1303. Elsevier Ltd.
Kaspers, G J L, Wijnands, J J, Hartmann, R, Huismans, L, Loonen, A H, Stackelberg, A, Henze, G, Pieters, R, Hahlen, K, van Wering, E R & Veerman, A J P 2005, ' Immunophenotypic cell lineage and in vitro cellular drug resistance in childhood relapsed acute lymphoblastic leukaemia ', European Journal of Cancer, vol. 41, no. 9, pp. 1300-1303 . https://doi.org/10.1016/j.ejca.2005.02.026
European Journal of Cancer, 41(9), 1300-1303. Elsevier Ltd.
Kaspers, G J L, Wijnands, J J, Hartmann, R, Huismans, L, Loonen, A H, Stackelberg, A, Henze, G, Pieters, R, Hahlen, K, van Wering, E R & Veerman, A J P 2005, ' Immunophenotypic cell lineage and in vitro cellular drug resistance in childhood relapsed acute lymphoblastic leukaemia ', European Journal of Cancer, vol. 41, no. 9, pp. 1300-1303 . https://doi.org/10.1016/j.ejca.2005.02.026
At relapse, T-cell acute lymphoblastic leukaemia (ALL) has a worse patient outcome than B-cell precursor (BCP-) ALL. To investigate this further, we compared in vitro cellular drug resistance profiles of T-cell and BCP-ALL samples obtained at relapse
Autor:
G. J. L. Kaspers, Hj. Broxterman, M. J. Wondergem, A H Loonen, U. Creutzig, T. G. K. J. De Haas, Rob Pieters, Gert J. Ossenkoppele, M. M. A. Rottier, Karel Hählen, S. Bartl, A. J. R. Veerman, R. WüNsche, Ch. M. Zwaan
Publikováno v:
Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ISBN: 9783642621093
Children with acute non-lymphoblastic leukemia (ANLL) experience a better clinical outcome than adults with ANLL. For younger adults (arbitrarily defined as age 60 years of age) experience a poor clinical outcome: CR rates are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb3e155f2104942883ea845a5c1f095
https://doi.org/10.1007/978-3-642-18156-6_42
https://doi.org/10.1007/978-3-642-18156-6_42
Autor:
A. J. P. Veerman, Gertjan J.L. Kaspers, C. H. Van Zantwijk, R. Pieters, G. J. Broekema, Eric G. Haarman, Karel Hählen
Publikováno v:
Drug Resistance in Leukemia and Lymphoma III ISBN: 9781461371809
The antileukemic activity of cytotoxic drugs is increasingly thought to be the result of induction of apoptosis. Several proto-oncogenes have been related to the regulation of this process. In this study we evaluated the relation between bcl-2 expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1723e930526b23d9af4ea42f538ca697
https://doi.org/10.1007/978-1-4615-4811-9_35
https://doi.org/10.1007/978-1-4615-4811-9_35