Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ryo, Ito"'
Autor:
Keita Kitamura, Ayaka Okamoto, Hanae Morio, Ryuto Isogai, Ryo Ito, Yoshiyuki Yamaura, Saki Izumi, Takafumi Komori, Shingo Ito, Sumio Ohtsuki, Hidetaka Akita, Tomomi Furihata
Publikováno v:
Molecular pharmaceutics. 19(8)
Blood-brain barrier (BBB)-permeable middle- or macromolecules (middle/macromolecules) have recently attracted significant attention as new drug delivery carriers into the human brain via receptor-mediated transcytosis (RMT). During the development pr
Autor:
Mai Mochizuki, Sadafumi Kawamura, Kazuto Matsuura, Keiichi Tamai, Takayuki Imai, Wataru Iwai, Jun Yasuda, Akira Sugawara, Yukinori Asada, Makoto Abue, Tomoko Yamazaki, Haruna Fujimori, Rie Shibuya-Takahashi, Satoshi Saijoh, Ryo Ito, Yukio Katori, Mao Nakamura-Shima, Kazuo Sugamura, Kazunori Yamaguchi, Yu Katayose, Yuta Wakui, Kennichi Satoh
Publikováno v:
Biochemical and Biophysical Research Communications. 537:132-139
Cancer stem cells (CSCs) are believed to cause cancer metastasis and recurrence. BEX2 (brain expressed X-linked gene 2) is a CSC-related gene that is expressed in dormant CSCs in cholangiocarcinoma and induces resistance against chemotherapy. The aim
Autor:
Ryo Ito, Yoshitomi Yayoi, Koji Watanabe, Teruki Hamada, Yasuhiro Hirata, Yasufumi Miyamoto, Seiji Miwatashi, Nobuyuki Takakura, Kazuaki Takami, Yoshihiko Hirozane, Naoyoshi Noguchi, Yusuke Moritoh, Mitsugi Ookawara, Hideki Furukawa, Jumpei Aida, Masanori Watanabe, Hitomi Yuko, Tsuyoshi Maekawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10352-10379
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Autor:
Shota Suzuki, Saki Izumi, Ken-ichi Nunoya, Takafumi Komori, Ryo Ito, Haruo Imawaka, Hidetaka Akita, Kenta Umehara, Keita Kitamura, Tomomi Furihata, Naomi Wakayama, Naohiko Anzai, Yoshiyuki Yamaura
Publikováno v:
Molecular pharmaceutics. 16(11)
Brain microvascular endothelial cells (BMEC), together with astrocytes and pericytes, form the blood-brain barrier (BBB) that strictly restricts drug penetration into the brain. Therefore, in central nervous system drug development, the establishment
Autor:
Keita Kitamura, Shota Suzuki, Hanae Morio, Naohiko Anzai, Kan Chiba, Hidetaka Akita, Kenta Umehara, Ryo Ito, Yoshiro Saito, Mari Hashimoto, Tomomi Furihata, Kosuke Saito
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 350-358 (2018)
Astrocytes have shown longstanding promise as therapeutic targets for various central nervous system diseases. To facilitate drug development targeting astrocytes, we have recently developed a new conditionally immortalized human astrocyte cell line,
Autor:
Shuji Kitamura, Nobuyuki Negoro, Nobuhiro Suzuki, Tsuneo Yasuma, Yu Momose, Masami Suzuki, Naoyuki Kanzaki, Satoshi Mikami, Takashi Santou, Ryo Ito, Shinobu Sasaki, Takeshi Miyazaki, Junichi Miyazaki, Yoshiyuki Tsujihata, Toshimasa Tanaka, Miyuki Funami
Publikováno v:
Journal of Medicinal Chemistry. 55:3756-3776
As part of a program to identify potent GPR40 agonists with drug-like properties suitable for clinical development, the incorporation of polar substituents was explored with the intention of decreasing the lipophilicity of our recently disclosed phen
Palladium on carbon-catalyzed solvent-free and solid-phase hydrogenation and Suzuki–Miyaura reaction
Autor:
Yuki Fujita, Yasunari Monguchi, Tohru Takahashi, Ryo Ito, Shota Hashimoto, Hironao Sajiki, Tomohiro Maegawa, Mariko Ina, Kei Nozaki
Publikováno v:
Tetrahedron. 67:8628-8634
The solvent-free and solid-phase hydrogenation of various reducible functionalities was efficiently catalyzed by heterogeneous palladium on carbon (Pd/C) under ambient hydrogen pressure and temperature. The Pd/C-catalyzed Suzuki–Miyaura coupling re
Autor:
Satoshi Mikami, Masami Suzuki, Yoshiyuki Tsujihata, Shinobu Sasaki, Takashi Santou, Masahiro Ito, Tomoyuki Odani, Toshimasa Tanaka, Nobuhiro Suzuki, Koji Takeuchi, Tsuneo Yasuma, Miyuki Funami, Shinichiro Matsunaga, Yu Momose, Junichi Miyazaki, Ryo Ito, Akifumi Kogame, Nobuyuki Negoro, Ayako Harada, Naoyuki Kanzaki
Publikováno v:
ACS Medicinal Chemistry Letters. 1:290-294
GPR40, one of the G protein-coupled receptors predominantly expressed in pancreatic β-cells, mediates enhancement of glucose-stimulated insulin secretion by free fatty acids. A potent and selective GPR40 agonist is theorized to be a safe and effecti
Publikováno v:
PPAR Research, Vol 2014 (2014)
PPAR Research
PPAR Research
Posttranslational modification (PTM) of proteins is critical for various cellular processes. However, there are few studies examining PTMs in specific proteins using unbiased approaches. Here we report the attempt to identify the PTMs in peroxisome p
Autor:
Masami Suzuki, Koji Takeuchi, Naoyuki Kanzaki, Tomoyuki Odani, Nobuhiro Suzuki, Yoshiyuki Tsujihata, Tsuneo Yasuma, Shinichiro Matsunaga, Masami Nonaka, Satoshi Mikami, Yu Momose, Takashi Santou, Shinobu Sasaki, Miyuki Funami, Junichi Miyazaki, Ryo Ito, Akio Morohashi, Nobuyuki Negoro, Masahiro Ito
Publikováno v:
Journal of medicinal chemistry. 55(8)
G protein-coupled receptor 40 (GPR40)/free fatty acid receptor 1 (FFA1) is a free fatty acid (FFA) receptor that mediates FFA-amplified glucose-stimulated insulin secretion in pancreatic β-cells. We previously identified (2,3-dihydro-1-benzofuran-3-