Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ah Young Park"'
Publikováno v:
Marine Drugs
Marine Drugs, Vol 20, Iss 12, p 12 (2022)
Marine Drugs; Volume 20; Issue 1; Pages: 12
Marine Drugs, Vol 20, Iss 12, p 12 (2022)
Marine Drugs; Volume 20; Issue 1; Pages: 12
Fucoidan compounds may increase immune activity and are known to have cancer inhibitory effects in vitro and in vivo. In this study, we aimed to investigate the effect of fucoidan compounds on ex vivo human peripheral blood mononuclear cells (PBMCs),
Autor:
Tauseef Ahmad, Mathew Suji Eapen, Muhammad Ishaq, Ah Young Park, Samuel S. Karpiniec, Damien N. Stringer, Sukhwinder Singh Sohal, J. Helen Fitton, Nuri Guven, Vanni Caruso, Rajaraman Eri
Publikováno v:
Marine Drugs
Marine Drugs; Volume 19; Issue 12; Pages: 702
Marine Drugs, Vol 19, Iss 702, p 702 (2021)
Marine Drugs; Volume 19; Issue 12; Pages: 702
Marine Drugs, Vol 19, Iss 702, p 702 (2021)
Fucoidans are sulfated, complex, fucose-rich polymers found in brown seaweeds. Fucoidans have been shown to have multiple bioactivities, including anti-inflammatory effects, and are known to inhibit inflammatory processes via a number of pathways suc
Autor:
J. Helen Fitton, Claire Richards, Samuel S Karpiniec, Neil A. Williams, Ah Young Park, Damien N. Stringer
Publikováno v:
Marine Drugs, Vol 18, Iss 246, p 246 (2020)
Marine Drugs
Marine Drugs
Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged a
Autor:
J. Schiebel, Johan Winquist, Ah Young Park, Franziska U. Huschmann, Xiaojie Wang, Andreas Heine, F.R. Ehrmann, Michael Betz, Gerhard Klebe, Manfred S. Weiss, Martin Stieler, Uwe Mueller, S.G. Krimmer, Nedyalka Radeva, Thomas Rickmeyer, Alexander Metz, Kan Fu
Publikováno v:
Journal of Medicinal Chemistry. 59:9743-9759
Crystallography is frequently used as follow-up method to validate hits identified by biophysical screening cascades. The capacity of crystallography to directly screen fragment libraries is often underestimated, due to its supposed low-throughput an
Publikováno v:
Marine Drugs
Marine Drugs, Vol 17, Iss 10, p 571 (2019)
Marine Drugs, Vol 17, Iss 10, p 571 (2019)
Since our last review in 2015, the study and use of fucoidan has extended in several research areas. Clinical use of fucoidan for the treatment of renal disease has become available and human safety studies have been undertaken on radiolabeled fucoid
Publikováno v:
Marine Drugs
Marine Drugs, Vol 19, Iss 4, p 4 (2021)
Marine Drugs, Vol 19, Iss 4, p 4 (2021)
Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections—including the current pandemic strain SARS-CoV-2—that affect lung function can cause both acute and long-term chronic damage. SARS-CoV
Autor:
Anna Knörlein, Michael Krug, Andreas Heine, Ah Young Park, Karine Röwer, Uwe Mueller, Franziska U. Huschmann, S.G. Krimmer, J. Schiebel, Manfred S. Weiss, F.R. Ehrmann, Kan Fu, Xiaojie Wang, Steffen Glöckner, Gerhard Klebe, Martin Stieler, Nedyalka Radeva
Publikováno v:
Structure. 24:1398-1409
Today the identification of lead structures for drug development often starts from small fragment-like molecules raising the chances to find compounds that successfully pass clinical trials. At the heart of the screening for fragments binding to a sp
Autor:
Kevin J. Spring, Raj Eri, Sandra Holmes, Kiran D.K. Ahuja, J. Helen Fitton, Ah Young Park, Nuri Gueven
Publikováno v:
Marine Drugs, Vol 18, Iss 3, p 143 (2020)
Marine Drugs
Marine Drugs
Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
Based upon the fact that l-nucleosides have been generally known to be less cytotoxic than d-counterparts, l-bicyclo[3.1.0]hexenyl carbanucleoside derivatives with a fixed north conformation were designed and synthesized by em
Based upon the fact that l-nucleosides have been generally known to be less cytotoxic than d-counterparts, l-bicyclo[3.1.0]hexenyl carbanucleoside derivatives with a fixed north conformation were designed and synthesized by em
Autor:
Won Hee Kim, Hyung-Rock Lee, Jungsu Kim, Jin-Ah Kang, Jungwon Choi, Ah-Young Park, Chong-Kyo Lee, Hyung Ryong Moon, Pusoon Chun, Lak Shin Jeong, Jin-Ah Kim
Publikováno v:
Tetrahedron. 66:1706-1715
The first synthesis of 2′-oxabicyclo[3.1.0]hexyl nucleosides, a novel class of bicyclonucleosides, with a north conformation was successfully accomplished starting from (S)-epichlorohydrin via a tandem alkylation–lactonization, a less steric hind