Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Preclinical research"'
Autor:
Thomas Hartung
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Animals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal mod
Externí odkaz:
https://doaj.org/article/d6c68c28933a414db9c90ffa3f8e778d
Publikováno v:
European Journal of Medical Research, Vol 27, Iss 1, Pp 1-17 (2022)
Abstract Hydrocephalus is a serious condition that affects patients of all ages, resulting from a multitude of causes. While the etiologies of hydrocephalus are numerous, many of the acute and chronic symptoms of the condition are shared. These sympt
Externí odkaz:
https://doaj.org/article/deea2bb978f24e9fadc6f0a3bc3cbedd
Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/15f32d17cd6a4cdb9fd91f53dc66745f
Autor:
Sanders DB; Division of Pediatric Pulmonology, Allergy and Sleep Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at IU Health, Indianapolis, Indiana, USA., Chmiel JF; Division of Pediatric Pulmonology, Allergy and Sleep Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at IU Health, Indianapolis, Indiana, USA.
Publikováno v:
Pediatric pulmonology [Pediatr Pulmonol] 2021 Feb; Vol. 56 Suppl 1, pp. S10-S22.
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/aaba5918d9b441738ed832e6cf34b3d9
Autor:
Varela-Nieto I; Neurobiology of Hearing Research Group, Endocrine and Nervous System Pathophysiology Department, Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Oto-Neurosurgery Research Group, Cancer and Human Molecular Genetics Department, IdiPAZ Research Institute , Madrid, Spain., Murillo-Cuesta S; Neurobiology of Hearing Research Group, Endocrine and Nervous System Pathophysiology Department, Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Oto-Neurosurgery Research Group, Cancer and Human Molecular Genetics Department, IdiPAZ Research Institute , Madrid, Spain., Calvino M; Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Oto-Neurosurgery Research Group, Cancer and Human Molecular Genetics Department, IdiPAZ Research Institute , Madrid, Spain.; Department of Otorhinolaryngology, La Paz University Hospital , Madrid, Spain., Cediel R; Neurobiology of Hearing Research Group, Endocrine and Nervous System Pathophysiology Department, Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Oto-Neurosurgery Research Group, Cancer and Human Molecular Genetics Department, IdiPAZ Research Institute , Madrid, Spain.; Department of Animal Medicine and Surgery, Complutense University of Madrid , Madrid, Spain., Lassaletta L; Institute for Biomedical Research 'Alberto Sols' CSIC-UAM , Madrid, Spain.; Oto-Neurosurgery Research Group, Cancer and Human Molecular Genetics Department, IdiPAZ Research Institute , Madrid, Spain.; Department of Otorhinolaryngology, La Paz University Hospital , Madrid, Spain.
Publikováno v:
Expert opinion on drug discovery [Expert Opin Drug Discov] 2020 Dec; Vol. 15 (12), pp. 1457-1471. Date of Electronic Publication: 2020 Aug 25.
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 7, Pp 1144-1147 (2019)
Due to the aging of the population and despite the enormous scientific effort, Alzheimer’s disease remains one of the biggest medical and pharmaceutical challenges in current medicine. Novel insights highlight the importance of neuroinflammation as
Externí odkaz:
https://doaj.org/article/84d275c4eebc4b8a80aaf3c3ee7eefc7
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Chronic pain is a common detrimental condition that affects around 20% of the world population. The current drugs to treat chronic pain states, especially neuropathic pain, have a limited clinical efficiency and present significant adverse effects th
Externí odkaz:
https://doaj.org/article/6d6d7db1deb44253856a50a8b1305931
Autor:
Morikazu Miyamoto, Manabu Kinoshita, Hiroki Ishibashi, Kohsuke Hagisawa, Tomoko Kure, Yukako Yuki, Hiromi Sakai, Masashi Takano, Katsuo Terui, Daizoh Saitoh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
We aimed to investigate the resuscitative efficacy of hemoglobin vesicles (HbVs) as a red blood cell (RBC) substitute for the initial treatment of severe postpartum hemorrhage (PPH). Twenty-five pregnant rabbits underwent cesarean section; uncontroll