Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Preclinical research"'
Autor:
Morikazu Miyamoto, Manabu Kinoshita, Hiroki Ishibashi, Kohsuke Hagisawa, Tomoko Kure, Yukako Yuki, Hiromi Sakai, Masashi Takano, Katsuo Terui, Daizoh Saitoh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
We aimed to investigate the resuscitative efficacy of hemoglobin vesicles (HbVs) as a red blood cell (RBC) substitute for the initial treatment of severe postpartum hemorrhage (PPH). Twenty-five pregnant rabbits underwent cesarean section; uncontroll
Autor:
Dake Qi, Siqian Fu, Cui Li, Baiyang You, Suixin Liu, Fan Zheng, Wenliang Zhang, Jeffrey W. Ripley-Gonzalez, Ling Qiu, Yaoshan Dun
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Obesity induces skeletal muscle dysfunction. The pathogenesis of which appears to substantially involve mitochondrial dysfunction, arising from impaired quality control. Exercise is a major therapeutic strategy against muscle dysfunction. Trimetazidi
Autor:
Peter Májek, Ruochen Jia, Michael Schuster, Leon Kutzner, Anna Koren, André C. Müller, Joanna I. Loizou, Robert Kralovics, Christoph Bock, Stefan Kubicek, Kathrin Runggatscher
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 7, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for small mole
Autor:
Diane R. Bielenberg, Hiroko Kishikawa, Victoria H. Ko, Mark Puder, Paul Mitchell, Jordan D. Secor, Amy Pan, Lumeng J. Yu, Bennet S. Cho, Duy T. Dao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Morbidity and mortality for neonates with congenital diaphragmatic hernia-associated pulmonary hypoplasia remains high. These patients may be deficient in vascular endothelial growth factor (VEGF). Our lab previously established that exogenous VEGF16
Autor:
Mithun Santra, Deeksha Katoch, Manni Luthra-Guptasarma, Maryada Sharma, Sahil Jain, Uma Nahar Saikia, Mangat R Dogra
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Induction of posterior vitreous detachment (PVD) by pharmacologic vitreolysis has been largely attempted through the use of enzymatic reagents. Ocriplasmin has been the only FDA-approved clinical reagent so far. Several adverse effects of ocriplasmin
Autor:
Nanna Skeltved, Mads Daugaard, Maj Sofie Ørum-Madsen, Thomas Mandel Clausen, Mie A. Nordmaj, Swati Choudhary, Zhang Yang, Robert Dagil, Kaare V. Grunddal, Emilie S. Sachse, Thor G. Theander, Weihua Tian, Ali Salanti, Morten Nielsen, Igor Moskalev, Sayit Mahmut Erdoğan, Morgan E. Roberts, Anne Poder Andersen, Tobias Gustsavsson
Publikováno v:
Cell Death & Disease
Nordmaj, M A, Roberts, M E, Sachse, E S, Dagil, R, Andersen, A P, Skeltved, N, Grunddal, K V, Erdoğan, S M, Choudhary, S, Gustavsson, T, Ørum-madsen, M S, Moskalev, I, Tian, W, Yang, Z, Clausen, T M, Theander, T G, Daugaard, M, Nielsen, M A & Salanti, A 2021, ' Development of a bispecific immune engager using a recombinant malaria protein ', Cell Death & Disease, vol. 12, no. 4, 353 . https://doi.org/10.1038/s41419-021-03611-0
Cell Death and Disease, Vol 12, Iss 4, Pp 1-11 (2021)
Nordmaj, M A, Roberts, M E, Sachse, E S, Dagil, R, Andersen, A P, Skeltved, N, Grunddal, K V, Erdoğan, S M, Choudhary, S, Gustavsson, T, Ørum-madsen, M S, Moskalev, I, Tian, W, Yang, Z, Clausen, T M, Theander, T G, Daugaard, M, Nielsen, M A & Salanti, A 2021, ' Development of a bispecific immune engager using a recombinant malaria protein ', Cell Death & Disease, vol. 12, no. 4, 353 . https://doi.org/10.1038/s41419-021-03611-0
Cell Death and Disease, Vol 12, Iss 4, Pp 1-11 (2021)
As an immune evasion and survival strategy, the Plasmodium falciparum malaria parasite has evolved a protein named VAR2CSA. This protein mediates sequestration of infected red blood cells in the placenta through the interaction with a unique carbohyd
Autor:
Kasper Mørk, Michael Sloth Trabjerg, Parisa Gazerani, Michal K. Oklinski, Jacek Lichota, Anne Skøttrup Mørkholt, Ivo J. Huijbers, Dennis Christian Andersen, Lona Kroese, John Nieland, Angelique Corthals, Colin Pritchard, Katrine Jønsson, Marie Louise Nibelius Skjønnemand
Publikováno v:
Trabjerg, M S, Mørkholt, A S, Lichota, J, Oklinski, M K E, Andersen, D C, Jønsson, K, Mørk, K, Skjønnemand, M-L N, Kroese, L J, Pritchard, C E J, Huijbers, I J, Gazerani, P, Corthals, A & Nieland, J D V 2020, ' Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders : experimental evidence based on animal models ', Scientific Reports, vol. 10, no. 1, 15583 . https://doi.org/10.1038/s41598-020-72638-8
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Trabjerg, M S, Mørkholt, A S, Lichota, J, Oklinski, M K E, Andersen, D C, Jønsson, K, Mørk, K, Skjønnemand, M L N, Kroese, L J, Pritchard, C E J, Huijbers, I J, Gazerani, P, Corthals, A & Nieland, J D V 2020, ' Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders : experimental evidence based on animal models ', Scientific Reports, vol. 10, no. 1, 15583 . https://doi.org/10.1038/s41598-020-72638-8
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Trabjerg, M S, Mørkholt, A S, Lichota, J, Oklinski, M K E, Andersen, D C, Jønsson, K, Mørk, K, Skjønnemand, M L N, Kroese, L J, Pritchard, C E J, Huijbers, I J, Gazerani, P, Corthals, A & Nieland, J D V 2020, ' Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders : experimental evidence based on animal models ', Scientific Reports, vol. 10, no. 1, 15583 . https://doi.org/10.1038/s41598-020-72638-8
The etiology of CNS diseases including multiple sclerosis, Parkinson’s disease and amyotrophic lateral sclerosis remains elusive despite decades of research resulting in treatments with only symptomatic effects. In this study, we provide evidence t
Autor:
Bo Falck Hansen, Henning Hvid, Jakob Brandt, Tine Glendorf, Anne Lützen, Rita Slaaby, Kim Kristensen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Insulin analogue X10 has a higher mitogenic potency than native human insulin in vitro and supra-pharmacological doses of insulin X10 increased the incidence of mammary tumours in rats. Compared to native human insulin, insulin X10 has increased bind
Autor:
Michael Becker, Aitomi Bittner, Martin Janz, Jens Hoffmann, Teresia Conrad, Bernadette Brzezicha, Ulrich Keilholz, Maria Stecklum, Clemens A. Schmitt
Publikováno v:
Cancer Research. 79:1069-1069
Lymphomas represent a very heterogeneous group of hematologic malignancies and pose an important challenge in the clinical routine. They frequently develop resistance to the treatment with standard-of-care (SoC) drugs and have a high incidence of dis