Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Preclinical research"'
Publikováno v:
European Journal of Medical Research, Vol 27, Iss 1, Pp 1-17 (2022)
Abstract Hydrocephalus is a serious condition that affects patients of all ages, resulting from a multitude of causes. While the etiologies of hydrocephalus are numerous, many of the acute and chronic symptoms of the condition are shared. These sympt
Externí odkaz:
https://doaj.org/article/deea2bb978f24e9fadc6f0a3bc3cbedd
Autor:
Morikazu Miyamoto, Manabu Kinoshita, Hiroki Ishibashi, Kohsuke Hagisawa, Tomoko Kure, Yukako Yuki, Hiromi Sakai, Masashi Takano, Katsuo Terui, Daizoh Saitoh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
We aimed to investigate the resuscitative efficacy of hemoglobin vesicles (HbVs) as a red blood cell (RBC) substitute for the initial treatment of severe postpartum hemorrhage (PPH). Twenty-five pregnant rabbits underwent cesarean section; uncontroll
Autor:
Dake Qi, Siqian Fu, Cui Li, Baiyang You, Suixin Liu, Fan Zheng, Wenliang Zhang, Jeffrey W. Ripley-Gonzalez, Ling Qiu, Yaoshan Dun
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Obesity induces skeletal muscle dysfunction. The pathogenesis of which appears to substantially involve mitochondrial dysfunction, arising from impaired quality control. Exercise is a major therapeutic strategy against muscle dysfunction. Trimetazidi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
By targeting invasive organisms, antibiotics insert themselves into the ancient struggle of the host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics, therapies decline in efficacy and must be replaced, distinguish
Autor:
Peter Májek, Ruochen Jia, Michael Schuster, Leon Kutzner, Anna Koren, André C. Müller, Joanna I. Loizou, Robert Kralovics, Christoph Bock, Stefan Kubicek, Kathrin Runggatscher
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 7, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for small mole
Autor:
Diane R. Bielenberg, Hiroko Kishikawa, Victoria H. Ko, Mark Puder, Paul Mitchell, Jordan D. Secor, Amy Pan, Lumeng J. Yu, Bennet S. Cho, Duy T. Dao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Morbidity and mortality for neonates with congenital diaphragmatic hernia-associated pulmonary hypoplasia remains high. These patients may be deficient in vascular endothelial growth factor (VEGF). Our lab previously established that exogenous VEGF16
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
BackgroundMüller cell (MC) inflammation is an early pathogenic step in the vision-threatening disease diabetic retinopathy (DR). Recent evidence indicates that diabetes-induced free fatty acid (FFA) dysregulation can elicit the release of inflammato
Autor:
Asim B. Abdel-Mageed, A. Hamid Boulares, Ahmed A Moustafa, Louis S Krane, Amrita Datta, Jacob W. Greenberg, Hogyoung Kim, Pedro C. Barata
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Renal Cell Carcinoma (RCC) is the most common form of kidney cancer, with clear cell RCC (ccRCC) representing about 85% of all RCC tumors. There are limited curable treatments available for metastatic ccRCC because this disease is unresponsive to con
Autor:
Baiwen Zhang, Cong Zhou, Yao Tang, Xiaojiao Cheng, Qingli Li, Jianzheng Wang, Fuli Li, Wenhui Zhang, Shuiping Tu, Ting-Lei Huang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Utidelone (UTD1), a novel microtubule stabilizing agent, is an epothilone B analogue which was produced by genetic engineering. UTD1 has exhibited broad antitumor activity in multiple solid tumors. However, its activity and mechanism in colorectal ca
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Chalcone derivatives are shown to possess excellent anti-inflammatory and anti-oxidant properties which are of great interest in treating respiratory diseases such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), chronic obstru