Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Preclinical research"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Chalcone derivatives are shown to possess excellent anti-inflammatory and anti-oxidant properties which are of great interest in treating respiratory diseases such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), chronic obstru
Autor:
Adina Boldeiu, Carsten Herskind, Mihaela Temelie, Roxana Cristina Popescu, D. A. Iancu, Frederik Wenz, Diana Savu, Frank A. Giordano, Hiltraud Hosser, I. Dorobantu, Bogdan Stefan Vasile, M. Straticiuc, Marlon R. Veldwijk, Ecaterina Andronescu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
The purpose of this study was to construct and characterize iron oxide nanoparticles (IONPCO) for intracellular delivery of the anthracycline doxorubicin (DOX; IONPDOX) in order to induce tumor cell inactivation. More than 80% of the loaded drug was
Autor:
Mithun Santra, Deeksha Katoch, Manni Luthra-Guptasarma, Maryada Sharma, Sahil Jain, Uma Nahar Saikia, Mangat R Dogra
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Induction of posterior vitreous detachment (PVD) by pharmacologic vitreolysis has been largely attempted through the use of enzymatic reagents. Ocriplasmin has been the only FDA-approved clinical reagent so far. Several adverse effects of ocriplasmin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The most challenging issue for breast cancer (BC) patients is metastasis to other organs because current therapies do not prevent or eliminate metastatic BC. Here, we show that SM-164, a small molecule inhibitor, which degrades inhibitor of apoptosis
Autor:
Dumitrascuta, Maria, Bermudez, Marcel, Ben Haddou, Tanila, Guerrieri, Elena, Schläfer, Lea, Ritsch, Andreas, Hosztafi, Sandor, Lantero, Aquilino, Kreutz, Christoph, Massotte, Dominique, Schmidhammer, Helmut, Wolber, Gerhard, Spetea, Mariana
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-62530-w⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-62530-w⟩
Morphine and structurally-derived compounds are µ opioid receptor (µOR) agonists, and the most effective analgesic drugs. However, their usefulness is limited by serious side effects, including dependence and abuse potential. The N-substituent in m
Autor:
Phillip P. Chan, Pamela O'sullivan, Vincent J. Capponi, Timothy J. Kovacs, Kathryn Dawson, Maryann Gruda, Karl-Gustav Ruggeberg, Thomas D. Golobish
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Mycotoxins, such as aflatoxin B1 (AFB1), pose a serious threat as biological weapons due to their high toxicity, environmental stability, easy accessibility and lack of effective therapeutics. This study investigated if blood purification therapy wit
Autor:
Danylo Kaminskyy, Roman Lesyk, Marcin L. Leja, Jan Gmiński, Konrad A. Szychowski, Tadeusz Pomianek, Jakub Tobiasz, Maciej Wnuk, Anna Kryshchyshyn
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
4-thiazolidinones, which are privileged structures in medicinal chemistry, comprise the well-known class of heterocycles and are a source of new drug-like compounds. Undoubtedly, the 5-bulky-substituted-2,4-thiazolidinediones - a class of antihypergl
Autor:
Kasper Mørk, Michael Sloth Trabjerg, Parisa Gazerani, Michal K. Oklinski, Jacek Lichota, Anne Skøttrup Mørkholt, Ivo J. Huijbers, Dennis Christian Andersen, Lona Kroese, John Nieland, Angelique Corthals, Colin Pritchard, Katrine Jønsson, Marie Louise Nibelius Skjønnemand
Publikováno v:
Trabjerg, M S, Mørkholt, A S, Lichota, J, Oklinski, M K E, Andersen, D C, Jønsson, K, Mørk, K, Skjønnemand, M-L N, Kroese, L J, Pritchard, C E J, Huijbers, I J, Gazerani, P, Corthals, A & Nieland, J D V 2020, ' Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders : experimental evidence based on animal models ', Scientific Reports, vol. 10, no. 1, 15583 . https://doi.org/10.1038/s41598-020-72638-8
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Trabjerg, M S, Mørkholt, A S, Lichota, J, Oklinski, M K E, Andersen, D C, Jønsson, K, Mørk, K, Skjønnemand, M L N, Kroese, L J, Pritchard, C E J, Huijbers, I J, Gazerani, P, Corthals, A & Nieland, J D V 2020, ' Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders : experimental evidence based on animal models ', Scientific Reports, vol. 10, no. 1, 15583 . https://doi.org/10.1038/s41598-020-72638-8
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Trabjerg, M S, Mørkholt, A S, Lichota, J, Oklinski, M K E, Andersen, D C, Jønsson, K, Mørk, K, Skjønnemand, M L N, Kroese, L J, Pritchard, C E J, Huijbers, I J, Gazerani, P, Corthals, A & Nieland, J D V 2020, ' Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders : experimental evidence based on animal models ', Scientific Reports, vol. 10, no. 1, 15583 . https://doi.org/10.1038/s41598-020-72638-8
The etiology of CNS diseases including multiple sclerosis, Parkinson’s disease and amyotrophic lateral sclerosis remains elusive despite decades of research resulting in treatments with only symptomatic effects. In this study, we provide evidence t
Autor:
Ana Gloria Gil, Fernando Martínez-Galan, Aina Casellas, Felix Hammann, Ángel Irigoyen-Barrio, Gloria Abizanda, Carlos Chaccour, Azucena Aldaz
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Chaccour, Carlos; Abizanda, Gloria; Irigoyen-Barrio, Ángel; Casellas, Aina; Aldaz, Azucena; Martínez-Galán, Fernando; Hammann, Felix; Gil, Ana Gloria (2020). Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats. Scientific reports, 10(1), p. 17073. 10.1038/s41598-020-74084-y
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Chaccour, Carlos; Abizanda, Gloria; Irigoyen-Barrio, Ángel; Casellas, Aina; Aldaz, Azucena; Martínez-Galán, Fernando; Hammann, Felix; Gil, Ana Gloria (2020). Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats. Scientific reports, 10(1), p. 17073. 10.1038/s41598-020-74084-y
"Ivermectin is a widely used antiparasitic drug with known efficacy against several single-strain RNA viruses. Recent data shows significant reduction of SARS-CoV-2 replication in vitro by ivermectin concentrations not achievable with safe doses oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871eaf6b7d9a7fd84d288d5efd0f294e
https://doi.org/10.21203/rs.3.rs-64501/v2
https://doi.org/10.21203/rs.3.rs-64501/v2
Autor:
Anna Wrobeln, Johannes Jägers, Theresa Quinting, Timm Schreiber, Michael Kirsch, Joachim Fandrey, Katja B. Ferenz
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Artificial blood for clinical use is not yet available therefore, we previously developed artificial oxygen carriers (capsules) and showed their functionality in vitro and biocompatibility in vivo. Herein, we assessed the functionality of the capsule