Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mitschler A"'
Autor:
Crespo I; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain., Giménez-Dejoz J; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain., Porté S; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain., Cousido-Siah A; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, UdS, 1 rue Laurent Fries, 67404, CEDEX Illkirch, France., Mitschler A; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, UdS, 1 rue Laurent Fries, 67404, CEDEX Illkirch, France., Podjarny A; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, UdS, 1 rue Laurent Fries, 67404, CEDEX Illkirch, France., Pratsinis H; Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre of Scientific Research 'Demokritos', Athens, Greece., Kletsas D; Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre of Scientific Research 'Demokritos', Athens, Greece., Parés X; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain., Ruiz FX; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, UdS, 1 rue Laurent Fries, 67404, CEDEX Illkirch, France. Electronic address: fxavier.ruiz@gmail.com., Metwally K; Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. Electronic address: kametwally@hotmail.com., Farrés J; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain. Electronic address: jaume.farres@uab.cat.
Publikováno v:
European journal of medicinal chemistry [Eur J Med Chem] 2018 May 25; Vol. 152, pp. 160-174. Date of Electronic Publication: 2018 Apr 12.
Autor:
Cousido-Siah A; Department of Integrative Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSER/UdS, 1 Rue Laurent Fries, 67404 Illkirch CEDEX, France., Ruiz FX; Department of Integrative Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSER/UdS, 1 Rue Laurent Fries, 67404 Illkirch CEDEX, France., Mitschler A; Department of Integrative Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSER/UdS, 1 Rue Laurent Fries, 67404 Illkirch CEDEX, France., Porté S; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain., de Lera ÁR; Departamento de Química Orgánica, Universidade de Vigo, 36310 Vigo, Spain., Martín MJ; Biomar Microbial Technologies S.A., Parque Tecnológico de León, 24009 León, Spain., Manzanaro S; Biomar Microbial Technologies S.A., Parque Tecnológico de León, 24009 León, Spain., de la Fuente JA; Biomar Microbial Technologies S.A., Parque Tecnológico de León, 24009 León, Spain., Terwesten F; Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany., Betz M; Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany., Klebe G; Department of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany., Farrés J; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain., Parés X; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain., Podjarny A; Department of Integrative Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSER/UdS, 1 Rue Laurent Fries, 67404 Illkirch CEDEX, France.
Publikováno v:
Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 2014 Mar; Vol. 70 (Pt 3), pp. 889-903. Date of Electronic Publication: 2014 Feb 27.
Autor:
Van Zandt MC; The Institute for Diabetes Discovery, LLC, 23 Business Park Drive, Branford, CT 06405, USA. michael.vanzandt@ipd-discovery.com, Sibley EO, McCann EE, Combs KJ, Flam B, Sawicki DR, Sabetta A, Carrington A, Sredy J, Howard E, Mitschler A, Podjarny AD
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2004 Nov 01; Vol. 12 (21), pp. 5661-75.
Autor:
Dimitris Kletsas, Sergio Porté, F.X. Ruiz, Jaume Farrés, Joan Gimenez-Dejoz, Harris Pratsinis, Isidro Crespo, Alberto Podjarny, Kamel Metwally, Alexandra Cousido-Siah, Andre Mitschler, Xavier Parés
Publikováno v:
European journal of medicinal chemistry. 152
Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic condition. Indeed, AKR1B1 overexpression is related to diabetes seco
Autor:
Francesc X. Ruiz, Michael Betz, Felix Terwesten, Jesús Ángel de la Fuente, Alberto Podjarny, Alexandra Cousido-Siah, Xavier Parés, Sonia Manzanaro, Sergio Porté, Gerhard Klebe, María Jesús Martín, Angel R. de Lera, Jaume Farrés, Andre Mitschler
Publikováno v:
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Aldo-keto reductases (AKRs) are mostly monomeric enzymes which fold into a highly conserved (α/β)8barrel, while their substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable exter
Autor:
F.X. Ruiz, Isidro Crespo, Angel R. de Lera, Alexandra Cousido-Siah, Susana Alvarez, Jaume Farrés, Andre Mitschler, Joan Gimenez-Dejoz, Alberto Podjarny, Sergio Porté, Xavier Parés
Publikováno v:
Chemico-biological interactions. 276
UVI2008, a retinoic acid receptor (RAR) β/γ agonist originated from C3 bromine addition to the parent RAR pan-agonist 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid (TTNPB), is also a selective inhibitor of
Autor:
Alberto Podjarny, Gerhard Klebe, C. Rechlin, Sergio Porté, Andre Mitschler, Xavier Parés, Alexandra Cousido-Siah, Jesús Ángel de la Fuente, Isidro Crespo, María Jesús Martín, Angel R. de Lera, Marta Domínguez, F.X. Ruiz, Jaume Farrés
Publikováno v:
ChemMedChem. 10(12)
The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2-(3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4
Autor:
Alberto Podjarny, Andre Mitschler, Kerry Combs, Evelyn O. Sibley, Al Sabetta, Erin E. McCann, Anne L. Carrington, Eduardo Howard, Diane R. Sawicki, Janet Sredy, Brenda R. Flam, Michael C. Van Zandt
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5661-5675
Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid aldose reductase inhibitors. The compound class features a
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