Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Zhirong Zhang"'
Publikováno v:
ACS Applied Materials & Interfaces. 14:51776-51789
Nanocrystals with high drug loading have become a viable strategy for solubilizing drugs with poor aqueous solubility. It remains challenging, however, to synthesize nanocrystals with sufficient stability and targeting potential. Here, we report a no
Publikováno v:
Molecular Pharmaceutics. 19:3934-3947
Herein, an albumin-enriched nanocomplex was developed for the solubilization and intravascular administration of clopidogrel bisulfate (CLP). In particular, CLP nanoparticles (HS-CLP-NPs) were synthesized via an improved nab-technology method using S
Autor:
Jie Tang, Li Zhang, Zhirong Zhang, Yayuan Liu, Huile Gao, Qifang Kuang, Qianyu Zhang, Han Fu, Rui Ran, Qin He
Tumor targeted drug delivery system with high efficiency of tumor accumulation, cell internalization and endosomal escape was considered ideal for cancer therapy. Herein, a cleavable polyethylene glycol (PEG) and octaarginines (R8) co-modified liposo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af91b60da5e3d87f7c94c158401580f
Autor:
Mou Wang, Sheng Yin, Zhirong Zhang, Qin He, Yiliang Yang, Shanshan Xu, Man Li, Yashi Wang, Lin Mei, Xuan He
Publikováno v:
Journal of Controlled Release. 321:71-83
Oxidative-stress defense system stands for the vulnerability of tumor cells because of the stronger oxidative stress existing in tumor sites. TRPA-1 has been found to be overexpressed in various tumors, related to the tumor proliferation and metastas
Publikováno v:
Acta Pharmacol Sin
Gemcitabine (Gem) is a standard first-line treatment for pancreatic cancer (PC). However, its chemotherapeutic efficacy is hampered by various limitations such as short half-life, metabolic inactivation, and lack of tumor localizing. We previously sy
Autor:
Ling Mei, Qin He, Sheng Yin, Man Li, Xian Tang, Ji Liu, Dandan Wan, Jiaojie Wei, Xuhui Wang, Yashi Wang, Zhirong Zhang, Jingdong Rao, Chunyu Xia
Publikováno v:
Acta Biomaterialia. 89:300-312
Autophagy plays a key role in the stress response of tumor cells, which contributes to cancer cell survival and resistance to chemotherapy by degrading cytoplasmic proteins to provide energy and clear the hazardous substances. Therefore, combined tre
Autor:
Ling Mei, Man Li, Qin He, Xuhui Wang, Haiyao Wu, Yue Qiu, Yayuan Liu, Qianwen Yu, Zhirong Zhang, Kai Liu, Xiaoxiao Chen
Publikováno v:
Theranostics
Pancreatic ductal adenocarcinoma (PDAC) is a type of malignant tumor with high lethality. Its high tumor cell-density and large variety of extracellular matrix (ECM) components present major barriers for drug delivery. Methods: Paclitaxel-loaded PEGy
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 165
Pancreatic ductal adenocarcinoma is one of the most lethal malignant tumors, its drug resistance, immunosuppression and metastasis makes the traditional chemotherapy and immunotherapy inefficient. Here we confirmed a 3-aminophenylboronic acid-modifie
Autor:
Kebai Ren, Jiao He, Man Li, Yue Qiu, Ling Mei, Wei Zhao, Jianping Li, Rong Guo, Qin He, Jiajing Tang, Yayuan Liu, Qianwen Yu, Shanshan Xu, Jiaojie Wei, Zhirong Zhang
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 329
Recurrence after tumor resection is mainly caused by post-operative inflammation and residual cancer cells, which is a serious obstacle to breast cancer treatment. Traditional nanoparticles rely primarily on the enhanced permeability and retention (E
Autor:
Caifeng Deng, Pei Zhang, Zhirong Zhang, Tao Gong, Ting Gong, Yuan Huang, Haohuan Li, Tiantian Tan
Publikováno v:
Biomaterials. 258
Palmitic acid-modified bovine serum albumin (PAB) was synthetized and found to own remarkable scavenger receptor-A (SR-A) targeting ability in vitro and in vivo, through which activated macrophages took up PAB nanoparticles (PAB NPs) 9.10 times more