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pro vyhledávání: '"R. Scott Hawley"'
Autor:
R. Scott Hawley, Amanda M. Bonner
Publikováno v:
Molecular Biology and Evolution
Meiosis is a defining characteristic of eukaryotes, believed to have evolved only once, over one billion years ago. While the general progression of meiotic events is conserved across multiple diverse organisms, the specific pathways and proteins inv
Publikováno v:
Current biology : CB. 30(4)
Polo-like kinases (PLKs) have numerous roles in both mitosis and meiosis, including functions related to chromosome segregation, cohesin removal, and kinetochore orientation [1-7]. PLKs require specific regulation during meiosis to control those proc
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 5, p e1008161 (2019)
PLoS Genetics, Vol 15, Iss 5, p e1008161 (2019)
During early meiotic prophase, homologous chromosomes are connected along their entire lengths by a proteinaceous tripartite structure known as the synaptonemal complex (SC). Although the components that comprise the SC are predominantly studied in t
Autor:
Kavyasree Nandanan, Yasuhiro Nakai, Laurence Florens, R. Scott Hawley, Michael P. Washburn, Selene K. Swanson, Satomi Takeo, Toshiro Aigaki
Publikováno v:
Proceedings of the National Academy of Sciences. 109:6382-6389
The Ca 2+ /Calmodulin-dependent phosphatase calcineurin is essential for exit from meiotic arrest at metaphases I and II in Drosophila and Xenopus oocytes. We previously found that Sarah, the Drosophila homolog of regulator of calcineurin, acts as a
Autor:
R. Scott Hawley, Fengli Guo, Cathleen M. Lake, Brian D. Slaughter, Jay R. Unruh, Rachel J. Nielsen
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
Meiotic recombination begins with the induction of programmed double-strand breaks (DSBs). In most organisms only a fraction of DSBs become crossovers. Here we report a novel meiotic gene, vilya, which encodes a protein with homology to Zip3-like pro
Publikováno v:
Cell Cycle. 7:698-701
Cell cycle progression in female meiotic systems is characterized by the presence of two or more pre-programmed arrests. One such arrest is invariable throughout all species--a lengthy G(2) arrest that separates the end of pachytene (by which homolog
Autor:
Jennifer K. Jeffress, Lorinda K. Anderson, Suzanne M. Royer, Justin P. Blumenstiel, Scott L. Page, Elizabeth D. Belden, R. Scott Hawley
Publikováno v:
Genetics. 177:2445-2456
In Drosophila melanogaster oocytes, the C(3)G protein comprises the transverse filaments (TFs) of the synaptonemal complex (SC). Like other TF proteins, such as Zip1p in yeast and SCP1 in mammals, C(3)G is composed of a central coiled-coil-rich domai
Publikováno v:
Genetics. 176:2151-2163
Members of the minichromosome maintenance (MCM) family have pivotal roles in many biological processes. Although originally studied for their role in DNA replication, it is becoming increasingly apparent that certain members of this family are multif
Autor:
R. Scott Hawley, Scott L. Page
Publikováno v:
Genetics. 170:1797-1807
The semisterile meiotic mutant mei-352 alters the distribution of meiotic exchanges without greatly affecting their total frequency. We show that the mei-352 mutation is an allele of the klp3A gene, which encodes a kinesin-like protein of the Kinesin
Publikováno v:
Current Biology. 15(7):672-677
SummaryThe conserved kinase Mps1 is necessary for the proper functioning of the mitotic and meiotic spindle checkpoints (MSCs), which monitor the integrity of the spindle apparatus and prevent cells from progressing into anaphase until chromosomes ar