Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ajay P. Singh"'
Autor:
Asif Zubair, Sanjeev K. Srivastava, Mohammad Aslam Khan, Ajay P. Singh, Girijesh Kumar Patel, Shafquat Azim, Haseeb Zubair, Seema Singh
Publikováno v:
J Proteome Res
Earlier we have shown important roles of MYB in pancreatic tumor pathobiology. To better understand the role of MYB in the tumor microenvironment and identify MYB-associated secreted biomarker proteins, we conducted mass spectrometry analysis of the
Publikováno v:
Cancer Research. 80:5070-5070
Breast cancer (BC) is the most frequently diagnosed malignancy and continues to be the second leading cause of cancer-related death in women in the United States. Dysregulation of Let-7 family microRNAs is observed in BC and associated with disease p
Autor:
Mohammad Aslam Khan, Santanu Dasgupta, Seema Singh, Ajay P. Singh, Moh’d Khushman, Shashi Anand
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5580, p 5580 (2020)
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5580, p 5580 (2020)
RAB proteins (RABs) represent the largest subfamily of Ras-like small GTPases that regulate a wide variety of endosomal membrane transport pathways. Their aberrant expression has been demonstrated in various malignancies and implicated in pathogenesi
Autor:
Nikhil Tyagi, Seema Singh, Ahmed Al-Ghadhban, James E. Carter, Mohammad Aslam Khan, Kari Dugger, Ajay P. Singh, Sanjeev K. Srivastava, Sachin Kumar Deshmukh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Chemotherapy-induced immunosuppression poses an additional challenge to its limited efficacy in pancreatic cancer (PC). Here we investigated the effect of gemcitabine on macrophages, which are the first line of immune-defense mechanisms. We observed
Autor:
Seema Singh, Shafquat Azim, James E. Carter, Mohammad Aslam Khan, Girijesh Kumar Patel, Aamir Ahmad, Arun Bhardwaj, Haseeb Zubair, Sumit Arora, Sanjeev K. Srivastava, Ajay P. Singh
Aberrant expression of the kinase IKKϵ in pancreatic ductal adenocarcinoma (PDAC) has been associated with poor prognosis. In this study, we define a pathobiologic function for IKKϵ in reprogramming glucose metabolism and driving progression in PDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3c7e5289192f6a0419933a7162da77
https://europepmc.org/articles/PMC5161695/
https://europepmc.org/articles/PMC5161695/
Autor:
Sanjeev K. Srivastava, Seema Singh, Richard E. Honkanen, Ajay P. Singh, Eddie Reed, Arun Bhardwaj
Publikováno v:
Molecular Cancer Therapeutics. 10:720-731
Earlier we identified PPP2CA, which encodes for the α-isoform of protein phosphatase 2A (PP2A) catalytic subunit, as one of the downregulated genes in androgen-independent prostate cancer. PP2A is a serine/threonine phosphatase and a potent tumor su
Autor:
Nikhil Tyagi, Kari Dugger, Arun Bhardwaj, Ahmed Al-Ghadhban, Mohammad Aslam Khan, Sachin Kumar Deshmukh, Sanjeev K. Srivastava, James E. Carter, Seema Singh, Ajay P. Singh
Publikováno v:
Cancer Research. 78:113-113
Resistance to chemotherapeutic drugs remains a major cause of therapeutic failure in pancreatic cancer (PC) patients. Efficacy of chemotherapy is further limited by its debilitating effects on immune system. Apart from genetic abnormalities in tumor
Autor:
Ajay P. Singh, Jayanth Panyam, Ameya R. Kirtane, Arun Bhardwaj, Sanjeev K. Srivastava, Seema Singh, Suresh Kumar Swaminathan, Sumit Arora
Publikováno v:
International Journal of Nanomedicine
Sumit Arora,1 Suresh K Swaminathan,2 Ameya Kirtane,2 Sanjeev K Srivastava,1 Arun Bhardwaj,1 Seema Singh,1 Jayanth Panyam,2 Ajay P Singh1,3 1Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA
Autor:
Seema Singh, Sanjeev K. Srivastava, Sumit Arora, James E. Carter, Courey Averett, Ajay P. Singh, Arun Bhardwaj
Publikováno v:
Cancer Research. 76:B02-B02
Pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the United States with a five year survival rate at just 6.0%. Its poor clinical outcome is largely attributed to its aggressive and metastatic nature as well as refractori
Autor:
Bin Wang, Sanjeev K. Srivastava, Ajay P. Singh, Arun Bhardwaj, William E. Grizzle, Sumit Arora, Seema Singh
Publikováno v:
Carcinogenesis. 32(12)
Pancreaticcancer (PC)has theworstprognosisamongallcancersdue to its late diagnosis and lack of effective therapies. Therefore,identification of novel gene targets, which are differentially ex-pressed in PC and functionally involved in malignant phen