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Publikováno v:
Biochemical Pharmacology. 86:1614-1620
The present study was aimed at assessing the influence of noradrenergic innervation of the paraventricular nucleus (PVN) and the arcuate nucleus (ARC) of the brain hypothalamus on cytochrome P450 expression in the liver. DSP-4, a neurotoxin specific
Fluphenazine decanoate (25 mg/kg IM every 3 weeks x 6) resulted in spontaneous vacuous chewing mouth movements and jaw tremor in male Sprague-Dawley rats. These movements could be suppressed by the selective D1 or D2 dopamine antagonists SCH 23390 (0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d883e2961ff1d3f8705a095f539a3d7c
https://ora.ox.ac.uk/objects/uuid:9f12da8e-5755-4fe8-82cb-ee78565a0f02
https://ora.ox.ac.uk/objects/uuid:9f12da8e-5755-4fe8-82cb-ee78565a0f02
Rats were given continuous infusions of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, 5 micrograms/h), a dopamine D-2 receptor agonist, using subcutaneous implants of ALZET osmotic minipumps. It was observed that tolerance occurred to the motor stimulan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8bd8a97dabb6d04d7039f78f9a0262
https://doi.org/10.1016/0014-2999(88)90037-4
https://doi.org/10.1016/0014-2999(88)90037-4
Publikováno v:
International Journal of Neuropsychopharmacology
Background: Dysfunction of dopaminergic, GABAergic, and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP), and post-weaning so
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:291-297
Apomorphine, a dopamine agonist with high affinity for presynaptic dopamine receptors, caused dose-dependent inhibition (10-300 micrograms/kg intravenously) of the stimulation-induced increase in diastolic blood pressure in the pithed rat. This effec
Publikováno v:
Acta Pharmacologica et Toxicologica. 52:51-56
B-HT 920 at low doses inhibited the accumulation of DOPA following treatment with reserpine and a DOPA decarboxylase inhibitor in the dopamine-, but not in the noradrenaline-predominant regions of the rat brain. B-HT 933 selectively inhibited this DO
Publikováno v:
Acta Pharmacologica et Toxicologica. 58:61-70
A number of potential neuroleptic drugs of the substituted benzamide type have been compared with some reference neuroleptic drugs regarding their affinities for rat brain receptors using in vitro receptor binding techniques. The effects on dopamine-
Autor:
Nils-Erik Andén, Helmut Wachtel
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:310-320
Baclofen (beta-parachlorophenyl-GABA) caused an increase in the concentration of dopamine in the rat brain with a maximum of about 170% of the control value after 1 hr and after doses of 50 mg/kg or more intraperitoneally. The alpha-methyltyrosine-in
Autor:
R. Klysner, A. Geisler
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:1-5
Lithium (5 and 20 mM) was found to inhibit the dopamine-stimulated cyclic AMP formation in homogenates from rat striatum and olfactory tubercle, leaving basal and fluoride-stimulated activities unaffected. The inhibition of dopamine-stimulated adenyl
Publikováno v:
Acta Pharmacologica et Toxicologica. 52:381-389
Adult male Wistar rats were administered acute toxic doses of lead (Pb), triethyl lead (TriEL) or tetraethyl lead (TEL) by gavage. The ability of striatal, hypothalamic and cortical synaptosomes to take up tritiated monoamines was assayed 24 hours la