Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sampsa Matikainen"'
Publikováno v:
Journal of Leukocyte Biology. 76:416-422
Interleukin (IL)-21 is a T cell-derived cytokine that regulates innate and adaptive immune responses. IL-21 receptor (IL-21R), which is expressed in natural killer (NK) and T cells, is structurally homologous to IL-2Rbeta and IL-15Ralpha. These recep
Autor:
Timo Sareneva, Riitta Lahesmaa, Ilkka Julkunen, Anne Lehtonen, Riikka Lund, Sampsa Matikainen
Publikováno v:
Cytokine. 24:81-90
IFN-alpha and IL-12 are macrophage-derived cytokines that enhance innate and Th1 immune responses. However, there is little information regarding IFN-alpha and IL-12 target genes that would be involved in mediating the immunostimulatory effects of th
Autor:
Timo Sareneva, Don Foster, Anne Lehtonen, Sampsa Matikainen, Ilkka Julkunen, Jukka Sirén, Mari Strengell
Publikováno v:
The Journal of Immunology. 170:5464-5469
NK and T cell-derived IFN-γ is a key cytokine that stimulates innate immune responses and directs adaptive T cell response toward Th1 type. IL-15, IL-18, and IL-21 have significant roles as activators of NK and T cell functions. We have previously s
Publikováno v:
The Journal of Immunology. 169:3600-3605
IL-21 is a recently characterized T cell-derived cytokine that regulates NK and T cell function. IL-21R shares the common γ-chain (γc) with the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Despite the same γc, these cytokines have different ef
Publikováno v:
Journal of Leukocyte Biology. 71:511-519
GM-CSF signals through JAK2 and STAT5 and stimulates the expression of STAT5 target genes, such as pim-1 and CIS. Analyzed by EMSA, GM-CSF stimulation led to much stronger STAT5 DNA-binding to pim-1 or CIS GAS elements in primary human monocytes comp
Autor:
Timo Sareneva, Carola Govenius-Vintola, Ilkka Julkunen, Minja Miettinen, Anne Lehtonen, Sampsa Matikainen, Jaana Pirhonen
Publikováno v:
Virology. 276:138-147
Chemokines regulate leukocyte traffic and extravasation into the site of inflammation. Here we show that influenza A- or Sendai virus-infected human macrophages produce MIP-1alpha, MIP-1beta, RANTES, MCP-1, MCP-3, MIP-3alpha, IP-10, and IL-8, whereas
Autor:
TAPANI RONNI, SAMPSA MATIKAINEN, ANNE LEHTONEN, JORMA PALVIMO, JOELLE DELLIS, FRANÇOISE VAN EYLEN, JEAN-FRANCOIS GOETSCHY, MICHEL HORISBERGER, JEAN CONTENT, ILKKA JULKUNEN
Publikováno v:
Journal of Interferon & Cytokine Research. 18:773-781
Interferon (IFN)-inducible human MxA protein mediates resistance against influenza and several other RNA viruses. The MxA gene is under the control of type I IFN and, in certain cell types, is also directly activated by viruses. Here we show that in
Autor:
Ville Veckman, Pamela Österlund, Jukka Sirén, Ilkka Julkunen, Kevin M. Klucher, Sampsa Matikainen, John Hiscott
Dendritic cells (DCs) respond to microbial infections by undergoing phenotypic maturation and by producing multiple cytokines. In the present study, we analyzed the ability of influenza A and Sendai viruses to induce DC maturation and activate tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d53b81c3fa54cfdf7b0326d848b028
https://europepmc.org/articles/PMC1181545/
https://europepmc.org/articles/PMC1181545/
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(4)
Toll-like receptors (TLRs) mediate host cell activation by various microbial components. TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9 are the receptors that have been associated with virus-induced immune response. We have previously reported that all these
Autor:
Sven, Erickson, Sampsa, Matikainen, Lena, Thyrell, Olle, Sangfelt, Ilkka, Julkunen, Stefan, Einhorn, Dan, Grandér
Publikováno v:
European journal of biochemistry. 269(1)
It has previously been shown that IFN-alpha is a potent inhibitor of IL-2 induced proliferation in primary T-lymphocytes, by selectively abrogating the downstream effects of IL-2 on the core cell cycle machinery regulating the G1/S transition. Theore