Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Susan P. Lees-Miller"'
Autor:
Alan E. Tomkinson, Susan Fishbain, Susan P. Lees-Miller, Yuan He, Siyu Chen, Tasmin Naila, Annie Wang, Linda Lee
Publikováno v:
Nature
DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the incorrect repair of DSBs is linked to carcinogenesis1,2. The conserved error-prone non-homologous end joining (NHEJ) pathway has a key role in determining the effects o
Autor:
Bruno Sangro, Christopher McCoy, Puri Fortes, Fernando Moreno-Herrero, Linda Lee, Sara de Bragança, Susan P. Lees-Miller, Oscar Llorca, Juan Pablo Unfried, Clara Aicart-Ramos, Gareth J. Williams, Laura Prats-Mari, Eva María Martín-Cuevas, Raquel Arribas-Bosacoma, Stefano Caruso, Angel Rivera-Calzada, Jessica Zucman-Rossi, Nerea Razquin, Mikel Marin-Baquero
Publikováno v:
Cancer Res
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancer Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancer Research
[Abstract] Long noncoding RNAs (lncRNA) are emerging as key players in cancer as parts of poorly understood molecular mechanisms. Here, we investigated lncRNAs that play a role in hepatocellular carcinoma (HCC) and identified NIHCOLE, a novel lncRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cae90efa1b6096c29d3ead27e258865
https://europepmc.org/articles/PMC8488005/
https://europepmc.org/articles/PMC8488005/
Autor:
Chirayu Chokshi, Alan E. Tomkinson, Shujuan Fang, Yoshihiro Matsumoto, Miaw-Sheue Tsai, Soumya G. Remesh, Sarvan Kumar Radhakrishnan, Monica Kuzdovich, John A. Tainer, Michal Hammel, Susan P. Lees-Miller, Yaping Yu
Publikováno v:
The Journal of Biological Chemistry
Hammel, M; Yu, Y; Radhakrishnan, SK; Chokshi, C; Tsai, MS; Matsumoto, Y; et al.(2016). An intrinsically disordered APLF links Ku, DNA-PKcs, and XRCC4-DNA ligase IV in an extended flexible non-homologous end joining complex. Journal of Biological Chemistry, 291(53), 26987-27006. doi: 10.1074/jbc.M116.751867. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/7ck582gw
The Journal of biological chemistry, vol 291, iss 53
Hammel, M; Yu, Y; Radhakrishnan, SK; Chokshi, C; Tsai, MS; Matsumoto, Y; et al.(2016). An intrinsically disordered APLF links Ku, DNA-PKcs, and XRCC4-DNA ligase IV in an extended flexible non-homologous end joining complex. Journal of Biological Chemistry, 291(53), 26987-27006. doi: 10.1074/jbc.M116.751867. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/7ck582gw
The Journal of biological chemistry, vol 291, iss 53
© 2016, American Society for Biochemistry and Molecular Biology Inc. All rights reserved. DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by recruitme
Autor:
Shikang Liang, Camille Duboc, Jing L. Wang, Tom L. Blundell, John A. Tainer, Susan E. Tsutakawa, Susan P. Lees-Miller, Marc Nadal, Takashi Ochi, Terence R. Strick, Qian Wu
Publikováno v:
Nature structuralmolecular biology. 25(6)
Repairing DNA double-strand breaks (DSBs) by nonhomologous end joining (NHEJ) requires multiple proteins to recognize and bind DNA ends, process them for compatibility, and ligate them together. We constructed novel DNA substrates for single-molecule
Autor:
David C. Schriemer, Cortt G. Piett, Michael Weinfeld, J. N. Mark Glover, Shujuan Fang, Ruiqiong Ye, John A. Tainer, Ross A. Edwards, Zahra Havali-Shahriari, R. Daniel Aceytuno, Fatima Javed, Rajam S. Mani, Martial Rey, Michal Hammel, Susan P. Lees-Miller
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (10), pp.6238-6251. ⟨10.1093/nar/gkx275⟩
Nucleic Acids Research, Oxford University Press, 2017, 45 (10), pp.6238-6251. ⟨10.1093/nar/gkx275⟩
International audience; Non-homologous end joining (NHEJ) repairs DNA double strand breaks in non-cycling eukaryotic cells. NHEJ relies on polynucleotide kinase/phosphatase (PNKP), which generates 5΄-phosphate/3΄-hydroxyl DNA termini that are criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865e84a730a59a99bb19d1b2f6d7322
https://hal.archives-ouvertes.fr/hal-03014077
https://hal.archives-ouvertes.fr/hal-03014077
Publikováno v:
DNA Repair. 17:2-8
Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks in human cells. Here, we discuss current insights into the mechanism of NHEJ and the interplay between NHEJ and other pathway
Autor:
Michael Weinfeld, John A. Tainer, Scott Classen, Michael E. Pique, Rajam S. Mani, Shujuan Fang, Michal Hammel, David C. Schriemer, Mona Liu, Susan P. Lees-Miller, Yaping Yu, Brandi L. Mahaney, Martial Rey
Publikováno v:
The Journal of Biological Chemistry
The XRCC4-like factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for DNA double strand breaks in human cells. Yet, how XLF binds XRCC4 and impacts nonhomologous end joining functions has been enigmatic. H
Publikováno v:
Structure. 18(11):1431-1442
SummaryDNA ligase IV (LigIV) is critical for nonhomologous end joining (NHEJ), the major DNA double-strand break (DSB) repair pathway in human cells, and LigIV activity is regulated by XRCC4 and XLF (XRCC4-like factor) interactions. Here, we employ s
Autor:
Meiling Lu, Yaping Yu, Michael Weinfeld, Nasser Tahbaz, Susan P. Lees-Miller, Dale A. Ramsden, Shujuan Fang, Rajam S. Mani, Angela E. Zolner, Mesfin Fanta, David W. Litchfield
Publikováno v:
Journal of Biological Chemistry. 285:37619-37629
XRCC4 plays a crucial role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair acting as a scaffold protein that recruits other NHEJ proteins to double-strand breaks. Phosphorylation of XRCC4 by protein kinase CK2 promot
Autor:
Michal Hammel, Susan P. Lees-Miller, Martin Pelikan, Sairei So, Yaping Yu, David J. Chen, Greg L. Hura, Robert P. Rambo, Ramin M. Abolfath, Ruiqiong Ye, Barry M. Phipps, Brandi L. Mahaney, Brandon Cai, John A. Tainer
Publikováno v:
The Journal of Biological Chemistry
DNA double strand break (DSB) repair by non-homologous end joining (NHEJ) is initiated by DSB detection by Ku70/80 (Ku) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) recruitment, which promotes pathway progression through poorly defin