Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Pavel Vodicka"'
Autor:
Yasmeen Niazi, Hauke Thomsen, Bozena Smolkova, Ludmila Vodickova, Sona Vodenkova, Michal Kroupa, Veronika Vymetalkova, Alena Kazimirova, Magdalena Barancokova, Katarina Volkovova, Marta Staruchova, Per Hoffmann, Markus M. Nöthen, Maria Dusinska, Ludovit Musak, Pavel Vodicka, Kari Hemminki, Asta Försti
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
DNA damage and unrepaired or insufficiently repaired DNA double-strand breaks as well as telomere shortening contribute to the formation of structural chromosomal aberrations (CAs). Non-specific CAs have been used in the monitoring of individuals exp
Externí odkaz:
https://doaj.org/article/67c08dd2adc745f7a352ef04e03c4aa4
Autor:
Miriam J. Kavec, Marketa Urbanova, Pavol Makovicky, Alena Opattová, Kristyna Tomasova, Michal Kroupa, Klara Kostovcikova, Anna Siskova, Nazila Navvabi, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5704 (2022)
Oxidative stress, oxidative DNA damage and resulting mutations play a role in colorectal carcinogenesis. Impaired equilibrium between DNA damage formation, antioxidant status, and DNA repair capacity is responsible for the accumulation of genetic mut
Externí odkaz:
https://doaj.org/article/df5a938844314a999f3a9b6f54b5dd40
Autor:
Kristyna Tomasova, Andrea Cumova, Karolina Seborova, Josef Horak, Kamila Koucka, Ludmila Vodickova, Radka Vaclavikova, Pavel Vodicka
Publikováno v:
Cancers, Vol 12, Iss 7, p 1713 (2020)
There is ample evidence for the essential involvement of DNA repair and DNA damage response in the onset of solid malignancies, including ovarian cancer. Indeed, high-penetrance germline mutations in DNA repair genes are important players in familial
Externí odkaz:
https://doaj.org/article/e82ba3a63f344ec0bbecfe9992fc95ea
Autor:
Pavel Vodicka, Marketa Urbanova, Pavol Makovicky, Kristyna Tomasova, Michal Kroupa, Rudolf Stetina, Alena Opattova, Klara Kostovcikova, Anna Siskova, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2473 (2020)
Oxidative stress with subsequent premutagenic oxidative DNA damage has been implicated in colorectal carcinogenesis. The repair of oxidative DNA damage is initiated by lesion-specific DNA glycosylases (hOGG1, NTH1, MUTYH). The direct evidence of the
Externí odkaz:
https://doaj.org/article/975e3a4273b44b248fc1687c4e478c17
Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer
Publikováno v:
Mutagenesis. 35:261-271
Colorectal cancer (CRC) continues to be one of the leading malignancies and causes of tumour-related deaths worldwide. Both impaired DNA repair mechanisms and disrupted telomere length homeostasis represent key culprits in CRC initiation, progression
Publikováno v:
Pharmacogenomics. 20:1225-1233
DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair
Autor:
Alena Opattova, Sabine A.S. Langie, Mirta Milic, Andrew Collins, Asgeir Brevik, Erdem Coskun, Maria Dusinska, Isabel Gaivão, Ela Kadioglu, Blanca Laffon, Ricard Marcos, Susana Pastor, Jana Slyskova, Bozena Smolkova, Zsófia Szilágyi, Vanessa Valdiglesias, Pavel Vodicka, Katarina Volkovova, Stefano Bonassi, Roger W.L. Godschalk
Publikováno v:
Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 876-877:503447. Elsevier
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 876-877:503447. Elsevier
Levels of DNA damage represent the dynamics between damage formation and removal. Therefore, to better interpret human biomonitoring studies with DNA damage endpoints, an individual's ability to recognize and properly remove DNA damage should be char
Autor:
Alena Kazimirova, Magdalena Barancokova, Sona Vodenkova, Marta Staruchova, Markus M. Nöthen, Maria Dusinska, Asta Försti, Ludovit Musak, Ludmila Vodickova, Per Hoffmann, Yasmeen Niazi, Kari Hemminki, Katarina Volkovova, Pavel Vodicka, Hauke Thomsen, Michal Kroupa, Bozena Smolkova, Veronika Vymetalkova
Publikováno v:
Environmental and Molecular Mutagenesis. 60:17-28
Chromosomal aberrations (CAs) in human peripheral blood lymphocytes (PBL) measured with the conventional cytogenetic assay have been used for human biomonitoring of genotoxic exposure for decades. CA frequency in peripheral blood is a marker of cance
Autor:
Katerina Lickova, Pavel Soucek, Andrea Cumova, Alena Opattova, Ludmila Vodickova, Pavel Vodicka, Barbara Pardini, Katerina Kopeckova, Renata Kozevnikovova, Veronika Vymetalkova, Miloslav Ambrus, Veronika Bouskova, Alessio Naccarati
Publikováno v:
Mutagenesis. 36(4)
Breast cancer (BC) is the most frequent malignancy in women accounting for approximately 2 million new cases worldwide annually. Several genetic, epigenetic and environmental factors are known to be involved in BC development and progression, includi
Autor:
Isabel Gaivão, Alena Opattova, Amaya Azqueta, Roger W. L. Godschalk, Peter Møller, Pavel Vodicka, Sabine A. S. Langie, Sona Vodenkova, Maria Dusinska, Andrew Collins
Publikováno v:
Nature Protocols, 15(12), 3844-3878. Nature Publishing Group
Vodenkova, S, Azqueta, A, Collins, A, Dusinska, M, Gaivao, I, Møller, P, Opattova, A, Vodicka, P, Godschalk, R W L & Langie, S A S 2020, ' An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity ', Nature Protocols, vol. 15, pp. 3844–3878 . https://doi.org/10.1038/s41596-020-0401-x
Nature Protocols
Vodenkova, S, Azqueta, A, Collins, A, Dusinska, M, Gaivao, I, Møller, P, Opattova, A, Vodicka, P, Godschalk, R W L & Langie, S A S 2020, ' An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity ', Nature Protocols, vol. 15, pp. 3844–3878 . https://doi.org/10.1038/s41596-020-0401-x
Nature Protocols
This optimized protocol (including links to instruction videos) describes a comet-based in vitro DNA repair assay that is relatively simple, versatile, and inexpensive, enabling the detection of base and nucleotide excision repair activity. Protein e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236e3676d540baba829f4f94c0f17895
https://cris.maastrichtuniversity.nl/en/publications/e033f6dc-1d6a-490e-ab22-99c28a0fc192
https://cris.maastrichtuniversity.nl/en/publications/e033f6dc-1d6a-490e-ab22-99c28a0fc192