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pro vyhledávání: '"Nahum Puebla-Osorio"'
Publikováno v:
Diabetes. 62:2429-2438
The genesis of β-cells predominantly occurs through self-replication; therefore, understanding the regulation of cell proliferation is essential. We previously showed that the lack of nonhomologous end joining (NHEJ) DNA repair factor ligase IV lead
Autor:
Nahum Puebla-Osorio, Chengming Zhu
Publikováno v:
Immunologic Research. 41:103-122
Lymphocyte maturation requires generation of a large diversity of antigen receptors, which involves somatic rearrangements at the antigen receptor genes in a process termed V(D)J recombination. Upon encountering specific antigens, B-lymphocytes under
Autor:
Stephen E. Ullrich, Nahum Puebla-Osorio, Omid Tavana, Cara L. Benjamin, Honnavara N. Ananthaswamy, Chengming Zhu, Mei Sang
Genotoxic stress triggers the p53 tumor suppressor network to activate cellular responses that lead to cell cycle arrest, DNA repair, apoptosis or senescence. This network functions mainly through transactivation of different downstream targets, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7abb8faf55a8ceb0598ac248b7f28d
https://europepmc.org/articles/PMC3041166/
https://europepmc.org/articles/PMC3041166/
Publikováno v:
Diabetes
OBJECTIVE Regulation of pancreatic β-cell mass is essential to preserve sufficient insulin levels for the maintenance of glucose homeostasis. Previously, we reported that DNA double-strand breaks (DSBs) resulting from nonhomologous end-joining (NHEJ
Publikováno v:
Molecular and cellular biology. 26(10)
DNA ligases catalyze the joining of strand breaks in the phosphodiester backbone of duplex DNA and play essential roles in DNA replication, recombination, repair, and maintenance of genomic integrity. Three mammalian DNA ligase genes have been identi