Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Hiroshi Sugiyama"'
Autor:
Masayuki Endo, Hiroshi Sugiyama
Publikováno v:
Molecules, Vol 23, Iss 7, p 1766 (2018)
DNA can assemble various molecules and nanomaterials in a programmed fashion and is a powerful tool in the nanotechnology and biology research fields. DNA also allows the construction of desired nanoscale structures via the design of DNA sequences. S
Externí odkaz:
https://doaj.org/article/85e8f32c4ca24daf8803dd886c120c69
Publikováno v:
Chemistry – A European Journal. 27:778-784
Stimuli-responsive switching molecules have been widely investigated for the purpose of the mechanical control of biomolecules. Recently developed arylazopyrazole (AAP) shows photoisomerization activity, displaying a faster response to light-induced
Publikováno v:
Chemistry – A European Journal. 26:15282-15289
The nucleosome is one of the most fundamental units involved in gene expression and consequent cell development, differentiation, and expression of cell functions. We report here a method to place reconstituted nucleosomes into a DNA origami frame fo
Autor:
Masayuki Endo, Graham Christie, Ioanna Mela, Robert M. Henderson, David Bailey, Pedro Vallejo-Ramirez, Stanislaw Makarchuk, Hiroshi Sugiyama, Clemens F. Kaminski
Publikováno v:
Angewandte Chemie (International Ed. in English)
We report the use of DNA origami nanostructures, functionalized with aptamers, as a vehicle for delivering the antibacterial enzyme lysozyme in a specific and efficient manner. We test the system against Gram‐positive (Bacillus subtilis) and Gram
Publikováno v:
Nucleic Acids Research
DNA methylation and demethylation play a key role in the epigenetic regulation of gene expression; however, a series of oxidation reactions of 5-methyl cytosine (5mC) mediated by ten-eleven translocation (TET) enzymes driving demethylation process ar
Autor:
Kumi Hidaka, Shozo Ohtsuki, Yuki Takahashi, Yoshinobu Takakura, Tatsuoki Maezawa, Makiya Nishikawa, Masayuki Endo, Hiroshi Sugiyama
Publikováno v:
Nanoscale. 12:14818-14824
DNA nanostructures are expected to be applied for targeted drug delivery to immune cells. However, the structural properties of DNA nanostructures required for the delivery have not fully been elucidated. In this study, we focused on the DNA density
Publikováno v:
ChemBioChem. 21:33-44
The nascent field of DNA nanotechnology has undergone rapid growth since its inception. By using DNA as a biologically "safe" material, DNA nanotechnology shows great promise in applications such as drug-delivery systems. Further progress, however, r
Publikováno v:
Chemical Communications. 57:5594-5596
We demonstrated the photo-controlled sequence-selective dsDNA cleavage using a DNA origami structure with Cas9 nuclease. The activity of Cas9 incorporated inside the ring-shaped DNA origami was completely suppressed. After photoirradiation, Cas9 was
Autor:
Tomoko Emura, Kumi Hidaka, Shengtao Yao, Yangyang Yang, Yufang Xu, Chunhai Fan, Rizhao Pan, Masayuki Endo, Shiwei Zhang, Xuhong Qian, Hiroshi Sugiyama
Publikováno v:
Chemistry – A European Journal. 25:5158-5162
Biological macromolecular machines perform impressive mechanical movements. F-adenosine triphosphate (ATP) synthase uses a proton gradient to generate ATP through mechanical rotations. Here, a programmed hexagonal DNA nanomachine, in which a three-ar
Autor:
Masayuki Endo, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa, Kumi Hidaka, Shozo Ohtsuki, Hiroshi Sugiyama, Yukako Shiba, Tatsuoki Maezawa
Publikováno v:
Nanoscale. 11:23416-23422
Despite the importance of the interaction between DNA and cells for its biological activity, little is known about exactly how DNA interacts with cells. To elucidate the relationship between the structural properties of DNA and its cellular uptake, a