Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Karin B. Michels"'
Autor:
Karin B. Michels, Alexandra M. Binder
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTFolate is an essential mediator in one-carbon metabolism, which provides methyl groups for DNA synthesis and methylation. The availability of active methyl groups can be influenced by the uptake of folic acid. We conducted a randomized interv
Externí odkaz:
https://doaj.org/article/423caddaed6445b5890254cd05da6d37
Autor:
Victor Yuan, E. Magda Price, Giulia Del Gobbo, Sara Mostafavi, Brian Cox, Alexandra M. Binder, Karin B. Michels, Carmen Marsit, Wendy P. Robinson
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background The influence of genetics on variation in DNA methylation (DNAme) is well documented. Yet confounding from population stratification is often unaccounted for in DNAme association studies. Existing approaches to address confounding
Externí odkaz:
https://doaj.org/article/02c4ae74a7e34e4682b3456b469c8329
Autor:
Hagen Klett, Yesilda Balavarca, Reka Toth, Biljana Gigic, Nina Habermann, Dominique Scherer, Petra Schrotz-King, Alexis Ulrich, Peter Schirmacher, Esther Herpel, Hermann Brenner, Cornelia M. Ulrich, Karin B. Michels, Hauke Busch, Melanie Boerries
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 386-397 (2018)
DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even of promote
Externí odkaz:
https://doaj.org/article/ca5222ded48e4e4da6ecdf8d76412d05
Autor:
Alexandra M. Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B. Michels
Publikováno v:
Epigenetics, Vol 13, Iss 1, Pp 85-94 (2018)
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal
Externí odkaz:
https://doaj.org/article/5ed7d26eaf9045098bb667506555021b
Publikováno v:
Epigenetics, Vol 12, Iss 10, Pp 875-885 (2017)
We investigated the impact of maternal smoking during pregnancy on placental DNA methylation and how this may mediate the association between maternal smoking and pro-inflammatory proteins in cord blood. The study population consisted of 27 individua
Externí odkaz:
https://doaj.org/article/344826d21d1f4a419b1788498846ec4e
Autor:
Nora Fernandez-Jimenez, Ruby Fore, Ariadna Cilleros-Portet, Johanna Lepeule, Patrice Perron, Tuomas Kvist, Fu-Ying Tian, Corina Lesseur, Alexandra M. Binder, Manuel Lozano, Jordi Martorell-Marugán, Yuk J. Loke, Kelly M. Bakulski, Yihui Zhu, Anne Forhan, Sara Sammallahti, Todd M. Everson, Jia Chen, Karin B. Michels, Thalia Belmonte, Pedro Carmona-Sáez, Jane Halliday, M. Daniele Fallin, Janine M. LaSalle, Jorg Tost, Darina Czamara, Mariana F. Fernández, Antonio Gómez-Martín, Jeffrey M. Craig, Beatriz Gonzalez-Alzaga, Rebecca J. Schmidt, John F. Dou, Evelyne Muggli, Marina Lacasaña, Martine Vrijheid, Carmen J. Marsit, Margaret R. Karagas, Katri Räikkönen, Luigi Bouchard, Barbara Heude, Loreto Santa-Marina, Mariona Bustamante, Marie-France Hivert, Jose Ramon Bilbao
Publikováno v:
Communications biology, vol 5, iss 1
Communications Biology, 5(1):1313. Springer Nature
Communications Biology, 5(1):1313. Springer Nature
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has
Autor:
Dominique Scherer, Melanie Boerries, Alexis Ulrich, Esther Herpel, Cornelia M. Ulrich, Biljana Gigic, Yesilda Balavarca, Hauke Busch, Hagen Klett, Reka Toth, Petra Schrotz-King, Peter Schirmacher, Hermann Brenner, Karin B. Michels, Nina Habermann
Publikováno v:
Epigenetics. 13:386-397
DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even of promote
Autor:
Karin B. Michels, Alexandra M. Binder, Benedetta Mussolin, Andrea Cassingena, Alice Vanzati, Mauro Truini, Salvatore Siena, Manel Esteller, Alessio Amatu, William M. Grady, Andrea Sartore-Bianchi, Simonetta Guarrera, Giulia Siravegna, Sebastian Moran, Sara Bustreo, Federica Di Nicolantonio, Alberto Bardelli, Patrizia Racca, Carlotta Cancelliere, Patrizia Zavattari, Daniele Oddo, Agostino Ponzetti, Giuseppe Matullo, Katia Bencardino, Carmen Cristiano, Sean K. Maden, Chiara Falcomatà, Ludovic Barault
Publikováno v:
Gut
ObjectiveMutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires personalised assay design due to the lack of universally mutated genes. In contrast, early methy
Publikováno v:
Epigenetics. 12:875-885
We investigated the impact of maternal smoking during pregnancy on placental DNA methylation and how this may mediate the association between maternal smoking and pro-inflammatory proteins in cord blood. The study population consisted of 27 individua
Autor:
Melanie Boerries, Hermann Brenner, Dominique Scherer, Stephanie Skender, Petra Schrotz-King, Alexis Ulrich, Peter Schirmacher, Martin F. Schneider, Lin Zielske, Nina Habermann, Timothy M. Barrow, Clare Abbenhardt-Martin, Hagen Klett, Jürgen Böhm, Cornelia M. Ulrich, Biljana Gigic, Karin B. Michels, Esther Herpel, Reka Toth, Hauke Busch
Publikováno v:
The Journal of Pathology. 243:366-375
Smoking tobacco is a known risk factor for the development of colorectal cancer, and for mortality associated with the disease. Smoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, although t