Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Susan P. Lees-Miller"'
Publikováno v:
Journal of Biological Chemistry. 292:14576-14586
Double strand breaks (DSBs) represent highly deleterious DNA damage and need to be accurately repaired. Homology directed repair (HDR) and non-homologous end-joining (NHEJ) are the two major DSB repair pathways that are highly conserved from yeast to
Autor:
John H.J. Petrini, Mathias Toulouze, Karine Dubrana, Aditya Mojumdar, Jennifer A. Cobb, Kyle Sorenson, Susan P. Lees-Miller, Marcel Hohl
Publikováno v:
Cell reports
SUMMARY Non-homologous end joining (NHEJ) and homologous recombination (HR) are the two major pathways of DNA double-strand break (DSB) repair and both are highly conserved from yeast to mammals. Nej1 has a role in DNA end-tethering at a DSB, and the
The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36f2f42bba373c580aa84cc66c9d4e2
https://europepmc.org/articles/PMC5549438/
https://europepmc.org/articles/PMC5549438/
Autor:
Caterina Marchetti, Pauline Douglas, Aaron A. Goodarzi, Nick Morrice, Penny A. Jeggo, Yaping Yu, Enriqueta Riballo, Sarah R. Walker, Susan P. Lees-Miller, Christine J. Härer, Ruiqiong Ye
Publikováno v:
The EMBO Journal. 25:3880-3889
The Artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients and is required for the repair of a subset of ionising radiation induced DNA double-strand breaks (DSBs) in an ATM and DNA-PK dependent process. Here, we sh
Publikováno v:
Nucleic Acids Research
Maintenance of telomere integrity requires the dynamic interplay between telomerase, telomere-associated proteins and DNA repair proteins. These interactions are vital to suppress DNA damage responses and changes in chromosome dynamics that can resul
Publikováno v:
Journal of Biological Chemistry. 279:39408-39413
Repair of chromosome breaks by non-homologous end joining requires the XRCC4-ligase IV complex, Ku, and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PKcs must also retain kinase activity and undergo autophosphorylation at six cl
Autor:
Susan P. Lees-Miller, David T. Cramb, Greg B. G. Moorhead, David P. Bazett-Jones, Zoya Leonenko, Pauline Douglas, Yaping Yu, Dennis Merkle
Publikováno v:
Biochemistry. 41:12706-12714
DNA double-strand breaks are a serious threat to genome stability and cell viability. One of the major pathways for the repair of DNA double-strand breaks in human cells is nonhomologous end-joining. Biochemical and genetic studies have shown that th
Autor:
Susan P. Lees Miller, Parimal Karmakar, Robert M. Brosh, Wen-Hsing Cheng, Dale A. Ramsden, Jason Piotrowski, Vilhelm A. Bohr, Joshua A. Sommers, Carey M. Snowden
Publikováno v:
Journal of Biological Chemistry. 277:18291-18302
Human Werner Syndrome is characterized by early onset of aging, elevated chromosomal instability, and a high incidence of cancer. Werner protein (WRN) is a member of the recQ gene family, but unlike other members of the recQ family, it contains a uni
Publikováno v:
Biochemistry. 38:1819-1828
Ku antigen is composed of 70 and 82 kDa subunits (Ku70 and Ku80, respectively) that together bind with high affinity to ends of double-stranded DNA and other DNA structures in vitro. When bound to DNA, the Ku 70/80 heterodimer enhances the kinase act
Publikováno v:
Journal of Biological Chemistry. 273:2136-2145
The DNA-dependent protein kinase (DNA-PK) is composed of a large catalytic subunit of approximately 470 kDa (DNA-PKcs) and the DNA-binding protein, Ku. Absence of DNA-PK activity confers sensitivity to x-rays and defects in both DNA double-strand bre