Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paulius Grigaravicius"'
Autor:
Zhao-Qi Wang, Holger Haselmann, Vahid Rahmati, Paulius Grigaravicius, Joanna Kirkpatrick, Mihai Ceanga, Christian Geis, Zhong-Wei Zhou, Murat Kirtay, Katrin Buder, Josefine Sell, Christian Marx, Alessandro Ori
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Ataxia Telangiectasia and Rad3-related (ATR) protein, as a key DNA damage response (DDR) regulator, plays an essential function in response to replication stress and controls cell viability. Hypomorphic mutations of ATR cause the human ATR-Seckel syn
Autor:
Rodrigo A. P. Martins, Pierre Olivier Frappart, Gabriel E. Matos-Rodrigues, Paulius Grigaravicius, Bernard S. Lopez, Thomas G. Hofmann
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 12, Pp 1-1 (2020)
Cell Death and Disease, Vol 11, Iss 12, Pp 1-1 (2020)
The maintenance of genomic stability during the cell cycle of progenitor cells is essential for the faithful transmission of genetic information. Mutations in genes that ensure genome stability lead to human developmental syndromes. Mutations in Atax
Autor:
Rodrigo A. P. Martins, Anielle L. Gomes, Paulius Grigaravicius, Pedro B. Tan, Pierre Olivier Frappart, Gabriel E. Matos-Rodrigues, Clara Forrer Charlier, Felipe Cabral-Miranda, Thomas G. Hofmann, Mauricio Rocha-Martins
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutu
Autor:
Kanstantsin Siniuk, Elena Ferrari, Christopher Bruhn, Harald Schuhwerk, Shamci Monajembashi, Tabea Zubel, Annika Krüger, Zhao-Qi Wang, Torsten Kroll, Paulius Grigaravicius, Wookee Min, Aswin Mangerich, Suheda Erener, Kirstin Kiesow, David Lázaro, Alexander Bürkle, Michael O. Hottiger
Publikováno v:
Nucleic Acids Research
Nucleic acids research, 45(19):11174-11192
Nucleic acids research, 45(19):11174-11192
One of the fastest cellular responses to genotoxic stress is the formation of poly(ADP-ribose) polymers (PAR) by poly(ADP-ribose)polymerase 1 (PARP1, or ARTD1). PARP1 and its enzymatic product PAR regulate diverse biological processes, such as DNA re
Autor:
Paulius Grigaravicius, Alexander Bürkle, Fu Li, Anja Krüger, Zhong-Wei Zhou, Zhao-Qi Wang, Chris Meisezahl, Oliver Popp, Bénazir Siddeek, Wookee Min, Christopher Bruhn, Karl-Otto Greulich, Cornelis F. Calkhoven, Xingzhi Xu
Publikováno v:
Nature Communications. 4
Damaged replication forks activate poly(ADP-ribose) polymerase 1 (PARP1), which catalyses poly(ADP-ribose) (PAR) formation; however, how PARP1 or poly(ADP-ribosyl)ation is involved in the S-phase checkpoint is unknown. Here we show that PAR, supplied
Publikováno v:
Mutagenesis. 24(2)
In DNA repair research, DNA damage is induced by different agents, depending on the technical facilities of the investigating researchers. A quantitative comparison of different investigations is therefore often difficult. By using a modified variant
Publikováno v:
Chemphyschem : a European journal of chemical physics and physical chemistry. 10(1)
We show how a technique developed within the framework of physics and physical chemistry-in a true interdisciplinary approach-can answer questions in life sciences that are not solvable by using other techniques. Herein, we focus on blood-pressure re
Autor:
Alexander Rapp, Shamci Monajembashi, Karl Otto Greulich, Götz Pilarczyk, Paulius Grigaravicius
Publikováno v:
SPIE Proceedings.
Incorrect DNA repair is probably one cause of healthy ageing. Laser microbeams or optical tweezers are emerging as convenient tools in the study of repair mechanisms. Using such tools, DNA damage can be induced in a preselected volume element of a ce