Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mengfan Tang"'
Autor:
Zhongming Zhao, Junjie Chen, Chao Wang, Zhen Chen, Mengfan Tang, Xu Feng, Dan Su, Guangsheng Pei, Mrinal Srivastava
Publikováno v:
Nucleic Acids Research
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we perfo
Autor:
Huimin Zhang, Yun Xiong, Dan Su, Chao Wang, Mrinal Srivastava, Mengfan Tang, Xu Feng, Min Huang, Zhen Chen, Junjie Chen
Publikováno v:
Nature Communications. 13
Anticancer drugs, such as camptothecin (CPT), trap topoisomerase I (TOP1) on DNA and form TOP1 cleavage complexes (TOP1cc). Alternative repair pathways have been suggested in the repair of TOP1cc. However, how these pathways work with TDP1, a key rep
Autor:
Chao Wang, Traver Hart, Klaudia Anna Szymonowicz, Dan Su, Xu Feng, Zhen Chen, Jeong Min Park, Mengfan Tang, Siting Li, Yun Xiong, Litong Nie, Junjie Chen, Huimin Zhang, Min Huang
Publikováno v:
Nucleic Acids Research
Because of essential roles of DNA damage response (DDR) in the maintenance of genomic integrity, cellular homeostasis, and tumor suppression, targeting DDR has become a promising therapeutic strategy for cancer treatment. However, the benefits of can
Publikováno v:
DNA Repair (Amst)
Genome integrity is constantly challenged by various DNA lesions with DNA double-strand breaks (DSBs) as the most cytotoxic lesions. In order to faithfully repair DSBs, DNA damage response (DDR) signaling networks have evolved, which organize many mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca829b9a47863251a0bc826980caf735
https://europepmc.org/articles/PMC8207832/
https://europepmc.org/articles/PMC8207832/
Autor:
Chao Wang, Megan McLaughlin, Gang Wang, Zhen Chen, Glen Traver Hart, Mengfan Tang, Xu Feng, Junjie Chen, Jie Zhang, Mrinal Srivastava, Peter Shepherd, Nora M. Navone
Publikováno v:
Oncogene
Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle control in response to replication stress, making ATR inhibition a promising therapeutic strategy for can
Autor:
Mengfan Tang1, Zhen Chen1, Chao Wang1, Xu Feng1, Namsoo Lee1, Min Huang1, Huimin Zhang1, Siting Li1, Yun Xiong1, Junjie Chen1 jchen8@mdanderson.org
Publikováno v:
Journal of Biological Chemistry. Jun2022, Vol. 298 Issue 6, p1-12. 12p.
Autor:
Siting Li, Junjie Chen, Huimin Zhang, Mengfan Tang, Zhongming Zhao, Chao Wang, Xu Li, Guangsheng Pei, Mrinal Srivastava, Zhen Chen, Xu Feng
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108018-(2020)
Cell reports
Cell reports
SUMMARY 53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficien
Autor:
Zhen Chen, Chao Wang, Anthony T. Tubbs, Dadi Jiang, Min Huang, Junjie Chen, Huimin Zhang, Litong Nie, Dan Su, Xu Feng, Sriram Sridharan, André Nussenzweig, Chunchao Zhang, Mengfan Tang, Yun Xiong
Publikováno v:
EMBO J
Mechanistic understanding of how ionizing radiation induces type I interferon signaling and how to amplify this signaling module should help to maximize the efficacy of radiotherapy. In the current study, we report that inhibitors of the DNA damage r
Publikováno v:
EMBO Rep
Replication across oxidative DNA lesions can give rise to mutations that pose a threat to genome integrity. How such lesions, which escape base excision repair, get removed without error during replication remains unknown. Our PCNA-based screen to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89919ee4e5b6d994be43bef3b4724b0
https://europepmc.org/articles/PMC7271331/
https://europepmc.org/articles/PMC7271331/
Autor:
Zhen Chen, Xu Feng, Huimin Zhang, Junjie Chen, Chao Wang, Yin Ye, Yun Xiong, Dan Cao, John A. Tainer, Mengfan Tang, Zu Ye, Mrinal Srivastava
Publikováno v:
Nucleic Acids Research
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that are repaired via a complex process requiring the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia, which is characterized by bone marrow failur