Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jiri Bartek"'
Autor:
Natalie Kudlova, Hanus Slavik, Pavlina Duskova, Tomas Furst, Josef Srovnal, Jiri Bartek, Martin Mistrik, Marian Hajduch
Publikováno v:
Aging (Albany NY)
In accordance with the 3 Rs principle (to replace, reduce and refine) animal models in biomedical research, we have developed and applied a new approach for sampling and analyzing hair follicles in various experimental settings. This involves use of
Autor:
Jesper V. Olsen, Diego Iglesias-Gato, Kim Hjorth-Jensen, Apolinar Maya-Mendoza, Jiri Bartek, Nanna Dalgaard, Amilcar Flores-Morales, Jón Otti Sigurðsson
Publikováno v:
Nucleic Acids Research
Hjorth-Jensen, K, Maya-Mendoza, A, Dalgaard, N, Sigurðsson, J O, Bartek, J, Iglesias-Gato, D, Olsen, J V & Flores-Morales, A 2018, ' SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability ', Nucleic Acids Research, vol. 46, no. 18, pp. 9484-9495 . https://doi.org/10.1093/nar/gky719
Hjorth-Jensen, K, Maya-Mendoza, A, Dalgaard, N, Sigurðsson, J O, Bartek, J, Iglesias-Gato, D, Olsen, J V & Flores-Morales, A 2018, ' SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability ', Nucleic Acids Research, vol. 46, no. 18, pp. 9484-9495 . https://doi.org/10.1093/nar/gky719
Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms behind this defect a
Autor:
Filip Novotny, Rastislav Dzijak, Ivan Stepanek, Filip Havel, Andrea Babelova, Michal Sramek, Monika Zarska, Kamil Musilek, Jiri Bartek, Ondrej Novak, J. Proska, Blanka Mrazkova, Monika Ursinyova, Zdenek Hodny, Oldrich Benada, Milan Reiniš, Kamil Kuca
Publikováno v:
Biomaterials
The exceptionally high cellular uptake of gold nanorods (GNRs) bearing cationic surfactants makes them a promising tool for biomedical applications . Given the known specific toxic and stress effects of some preparations of cationic nanoparticles, th
Autor:
Jiri Bartek, Olesja Fornara, Joanna Maria Merchut-Maya, Apolinar Maya-Mendoza, Afshar Rahbar, Giuseppe Stragliotto, Helle Broholm, Mikael Svensson, Astrid Sehested, Cecilia Söderberg Naucler, Jirina Bartkova
Publikováno v:
Molecular Oncology
Medulloblastomas are the most common, and often fatal, paediatric brain tumours that feature high genomic instability, frequent infection by human cytomegalovirus (HCMV) and resistance to radiation and chemotherapy. The causes of the pronounced chrom
Autor:
Petra Hamerlik, Jirina Bartkova, Christina E. Hoei-Hansen, Ewa Rajpert-De Meyts, Katerina Krizova, Niels E. Skakkebæk, Jiri Bartek
Publikováno v:
Molecular Oncology. 8:1667-1678
The DNA damage response (DDR) machinery becomes commonly activated in response to oncogenes and during early stages of development of solid malignancies, with an exception of testicular germ cell tumors (TGCTs). The active DDR signaling evokes cell d
Autor:
Vassilis Zoumpourlis, Jiri Bartek, Thanos D. Halazonetis, Ayguel Dereli-Oz, Wei Gu, Jirina Bartkova, Sladana Bursac, Siniša Volarević, Theodoros I. Roumeliotis, Apostolos Klinakis, Dimitris Kletsas, Kostas Evangelou, Georgia Velimezi, Maria Sideridou, Maja Cokaric-Brdovcak, Athanassios Kotsinas, Michalis Liontos, Vassilis G. Gorgoulis, Konstantinos Vougas, Ioannis S. Pateras, Maciej K. Kocylowski, Ines Orsolic, George Papafotiou
Publikováno v:
Nature cell biology
The DNA damage response (DDR) pathway and ARF function as barriers to cancer development. Although commonly regarded as operating independently of each other, some studies proposed that ARF is positively regulated by the DDR. Contrary to either scena
Autor:
Radek Vrtel, Alena Mickova, Alena Burdova, Martin Mistrik, Jan Bouchal, Jirina Bartkova, Milan Král, Frédéric R. Santer, Jiri Bartek, Daniela Kurfürstová, Dusana Majera
Publikováno v:
Molecular oncology. 10(6)
The DNA damage checkpoints provide an anti-cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a cancer treatment stra
Autor:
C-C Pan, V Hvidberg, Niels Fristrup, Philippe Lamy, Troels Schepeler, Laurence Tropia, Torben F. Ørntoft, Lars Dyrskjøt, Thomas Reinert, Thanos D. Halazonetis, Jirina Bartkova, Jiri Bartek, Michael Borre, Jens R. Laurberg
Publikováno v:
Schepeler, T, Lamy, P, Hvidberg, V, Laurberg, J R, Fristrup, N, Reinert, T, Bartkova, J, Tropia, L, Bartek, J, Halazonetis, T D, Pan, C-C, Borre, M, Andersen, L D & Orntoft, T F 2013, ' A high resolution genomic portrait of bladder cancer : correlation between genomic aberrations and the DNA damage response ', Oncogene, vol. 32, pp. 3577-3586 . https://doi.org/10.1038/onc.2012.381
One major challenge in cancer research is to understand the complex interplay between the DNA damage response (DDR), genomic integrity, and tumor development. To address these issues, we analyzed 43 bladder tumor genomes from 22 patients using single
Autor:
Doron Ginsberg, Kalliopi Apostolopoulou, Christos Kittas, Thanos D. Halazonetis, George Th. Tsangaris, Katerina Niforou, Radek Vrtel, Jiri Bartek, Panayiotis Kontovazenitis, Athanassios Kotsinas, Vassilis Zoumpourlis, Georgia Velimezi, Michalis Liontos, Vassilis G. Gorgoulis, Konstantinos Vougas, Alexandros Damalas, Konstantinos Evangelou
Publikováno v:
The American Journal of Pathology; Vol 175
Osteosarcoma is the most common primary bone cancer. Mutations of the RB gene represent the most frequent molecular defect in this malignancy. A major consequence of this alteration is that the activity of the key cell cycle regulator E2F1 is unleash
Publikováno v:
International Journal of Andrology. 30:282-291
DNA damage response (DDR) is emerging as a physiological anti-cancer barrier in early stages of cancer development, as shown for several types of solid cancers derived from somatic cells. Here we discuss our recently published and unpublished results