Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Robert Landick"'
Publikováno v:
J Mol Biol
Journal of molecular biology, vol 431, iss 20
Journal of molecular biology, vol 431, iss 20
Pausing by RNA polymerase (RNAP) during transcription regulates gene expression in all domains of life. In this review, we recap the history of transcriptional pausing discovery, summarize advances in our understanding of the underlying causes of pau
Autor:
Beth A. Shen, Robert Landick
Publikováno v:
J Mol Biol
Decades of research have probed the interplay between chromatin (genomic DNA associated with proteins and RNAs) and transcription by RNA polymerase (RNAP) in all domains of life. In bacteria, chromatin is compacted into a membrane-free region known a
Autor:
Daniel R Hron, Ramon A van der Valk, Liang Qin, Beth A Boudreau, Remus T. Dame, Robert Landick, Matthew V Kotlajich
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 46(11), 5525-5546
Nucleic Acids Research, 46(11), 5525-5546
In enterobacteria, AT-rich horizontally acquired genes, including virulence genes, are silenced through the actions of at least three nucleoid-associated proteins (NAPs): H-NS, StpA and Hha. These proteins form gene-silencing nucleoprotein filaments
Autor:
Jeff Gelles, Rachel A. Mooney, Ivan R Corrêa Jnr, Robert Landick, Sarah K Stumper, Harini Ravi, Larry J. Friedman, Anne Gershenson
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
RNA polymerases (RNAPs) contain a conserved ‘secondary channel’ which binds regulatory factors that modulate transcription initiation. In Escherichia coli, the secondary channel factors (SCFs) GreB and DksA both repress ribosomal RNA (rRNA) trans
Autor:
Melisa L. Osborne, Jeff Gelles, Robert Landick, Sarah K Stumper, Larry E. Tetone, Rachel A. Mooney, Harini Ravi, Larry J. Friedman, Scotty Kyzer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(7)
The secondary channel (SC) of multisubunit RNA polymerases (RNAPs) allows access to the active site and is a nexus for the regulation of transcription. Multiple regulatory proteins bind in the SC and reprogram the catalytic activity of RNAP, but the
Publikováno v:
Annual review of biochemistry. 85
Transcript termination is essential for accurate gene expression and the removal of RNA polymerase (RNAP) at the ends of transcription units. In bacteria, two mechanisms are responsible for proper transcript termination: intrinsic termination and Rho
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
Initiation of transcription is a primary means for controlling gene expression. In bacteria, the RNA polymerase (RNAP) holoenzyme binds and unwinds promoter DNA, forming the transcription bubble of the open promoter complex (RPo). We have determined
Publikováno v:
Molecular Cell. 44:635-646
Transcriptional pausing by RNA polymerase (RNAP) plays an essential role in gene regulation. Pausing is modified by various elongation factors, including prokaryotic NusA, but the mechanisms underlying pausing and NusA function remain unclear. Altern
Publikováno v:
Cell. 115:437-447
RNA polymerase (RNAP) transcribes DNA discontinuously, with periods of rapid nucleotide addition punctuated by frequent pauses. We investigated the mechanism of transcription by measuring the effect of both hindering and assisting forces on the trans
Publikováno v:
Science. 302:650-654
RNA polymerase (RNAP) is the central enzyme of gene expression. Despite availability of crystal structures, details of its nucleotide addition cycle remain obscure. We describe bacterial RNAP inhibitors (the CBR703 series) whose properties illuminate