Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Robert Landick"'
Autor:
Robert Landick
Publikováno v:
Annual Review of Microbiology. 75:291-314
Cellular life depends on transcription of DNA by RNA polymerase to express genetic information. RNA polymerase has evolved not just to read information from DNA and write it to RNA but also to sense and process information from the cellular and extra
Autor:
Rolf Müller, Robert Landick, Mirjana Lilic, Jennifer Herrmann, Rachel A. Mooney, Hande Boyaci, Elizabeth A. Campbell, Nathaniel Braffman, James Chen, Seth A. Darst, Elizabeth A. Hubin
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30423-30432
Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis (Mtb). The emergence of Rif-resistant (RifR) Mtb presents a need for new antibiotics. Rif
Autor:
Gene-Wei Li, Timothy T. Harden, Jeff Gelles, Jean-Benoît Lalanne, Jane Kondev, Ann Hochschild, Mathew Chamberlain, Karina S. Herlambang, Christopher D. Wells, Robert Landick
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
RNA polymerases (RNAPs) transcribe genes through a cycle of recruitment to promoter DNA, initiation, elongation, and termination. After termination, RNAP is thought to initiate the next round of transcription by detaching from DNA and rebinding a new
Publikováno v:
J Mol Biol
Journal of molecular biology, vol 431, iss 20
Journal of molecular biology, vol 431, iss 20
Pausing by RNA polymerase (RNAP) during transcription regulates gene expression in all domains of life. In this review, we recap the history of transcriptional pausing discovery, summarize advances in our understanding of the underlying causes of pau
Autor:
Beth A. Shen, Erik Jessen, Daniel Roston, Christine M. Hustmyer, Michael B. Wolfe, Robert Landick
SUMMARYGene silencing in bacteria is mediated by chromatin proteins, of which Escherichia coli H-NS is a paradigmatic example. H-NS forms nucleoprotein filaments with either one or two DNA duplexes. However, the structures, arrangements of DNA-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa6962b87b38fc0307c831ca0150716
https://doi.org/10.1101/2020.06.11.146589
https://doi.org/10.1101/2020.06.11.146589
Autor:
Daniel R Hron, Ramon A van der Valk, Liang Qin, Beth A Boudreau, Remus T. Dame, Robert Landick, Matthew V Kotlajich
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 46(11), 5525-5546
Nucleic Acids Research, 46(11), 5525-5546
In enterobacteria, AT-rich horizontally acquired genes, including virulence genes, are silenced through the actions of at least three nucleoid-associated proteins (NAPs): H-NS, StpA and Hha. These proteins form gene-silencing nucleoprotein filaments
Autor:
Tricia A. Windgassen, Tatiana V. Mishanina, Xien Yu Chua, Rachel A. Mooney, Robert Landick, Jason Saba, Dhananjaya Nayak
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Transcriptional pausing underlies regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise. Althou
In bacteria, disassembly of elongating transcription complexes (ECs) can occur at intrinsic terminators in a 2-3 nucleotide window after transcription of multiple kilobase pairs of DNA. Intrinsic terminators trigger pausing on weak RNA-DNA hybrids fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf1e078984a871533064f0c0b2d1b43
https://doi.org/10.1101/453969
https://doi.org/10.1101/453969
Autor:
Jin Young Kang, Rachel A. Mooney, Jason Saba, Yuri Nedialkov, Robert Landick, Irina Artsimovitch, Seth A. Darst, Tatiana V. Mishanina
SUMMARYNusG/RfaH/Spt5 transcription elongation factors are the only transcription regulators conserved across all life. In bacteria, NusG regulates RNA polymerase (RNAP) elongation complexes (ECs) across most genes, enhancing elongation by suppressin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e6f5f50c3dfa08f5ef791e89ee43f9
https://doi.org/10.1101/324400
https://doi.org/10.1101/324400
Autor:
Jason Saba, Tatiana V. Mishanina, Yuri Nedialkov, Rachel A. Mooney, Jin Young Kang, Seth A. Darst, Irina Artsimovitch, Robert Landick
Publikováno v:
Cell. 173(7)
Summary NusG/RfaH/Spt5 transcription elongation factors are the only transcription regulators conserved across all life. Bacterial NusG regulates RNA polymerase (RNAP) elongation complexes (ECs) across most genes, enhancing elongation by suppressing