Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Nathan A. Berger"'
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236045 (2020)
PLoS ONE
PLoS ONE
Epigenetic age acceleration-the difference between an individual's DNA methylation age and chronological age-is associated with many diseases including cancer. This study aims to evaluate epigenetic age acceleration as a prognostic biomarker for glio
Publikováno v:
Biochemical Journal. 382:323-329
Poly(ADP-ribose) polymerase-1 (PARP-1) is a co-activator for AP-2alpha (activator protein 2alpha)-mediated transcriptional activation. In the present study, we find that the role of PARP-1 in AP-2alpha transcription is distinctly dualistic with oppos
Autor:
Laura S Ray, Satadal Chatterjee, Nathan A. Berger, Valentina I. Grishko, Glenn L. Wilson, Susan P. LeDoux
Publikováno v:
Mutation Research/DNA Repair. 363:105-114
The role of poly(ADP-ribose) polymerase (PADPRP) in nuclear DNA repair and other nuclear processes has been intensely studied and debated for decades. Recent studies have begun to shed new light on these arguments with firm experimental data for its
Autor:
Jennifer Meyers, John R. Apgar, Walter Eckhart, Nathan A. Berger, Patrice S. Obermiller, David S. Ucker
Publikováno v:
Molecular and Cellular Biology. 12:3060-3069
We examined virally transformed murine fibroblast clones as targets for cytotoxic T lymphocyte (CTL)-triggered lysis and genome digestion. Strikingly, while all clones were essentially equivalent in the ability to be lysed, one clone, SV3T3-B2.1, fai
Autor:
Satadal Chatterjee, Nathan A. Berger
Publikováno v:
International Journal of Oncology.
We studied the role of PARP in X-ray-induced damage repair using V79 Chinese hamster cells and two derivative cell lines ADPRT54 and ADPRT351 deficient in poly(adenosine diphosphate-ribose) polymerase (PARP) activity. We previously demonstrated that
Autor:
Nathan A. Berger
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 4:1-3
Oxidant injury to cells and tissues, induced by reactive oxygen metabolites such as superoxide anion, hydrogen peroxide, and hydroxyl radical, involves chemical alterations in proteins, lipids, carbohydrates, and nucleic acids (1-3). Perturbations to
Autor:
Nathan A. Berger, Lawrence Panasci, Areti Malapetsa, Serge Desnoyers, Guy G. Poirier, Adrian J. Noë
Publikováno v:
Mutation research. 362(1)
SKI-1 is a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-resistant glioma cell line and SK-MG-1 is a BCNU-sensitive glioma cell line. Both cell lines do not express O6-methylguanine-DNA methyl transferase (MGMT) and exhibit comparable levels of 3-methy
Publikováno v:
ADP-Ribosylation Reactions ISBN: 9781461264569
ADPRT 54 and ADPRT 351, are Chinese hamster, V79, derived mutant cell lines, selected for their marked deficiency in poly(ADP-ribose) polymerase activity (1). These cells were employed to analyze the effect of poly(ADP-ribose) polymerase deficiency o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d56640a97fd7d18e8cf5d080fceaa6a
https://doi.org/10.1007/978-1-4419-8718-1_52
https://doi.org/10.1007/978-1-4419-8718-1_52
We have shown previously a good correlation between etoposide-induced sister chromatid exchanges (SCE) and cytotoxicity. A semisynthetic derivative of podophyllotoxin, etoposide is also called Vepesid (Bristol; code designation VP-16-213, abbreviated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3042042085df2381df9b1a32d58c6dc
https://europepmc.org/articles/PMC52585/
https://europepmc.org/articles/PMC52585/
Publikováno v:
Cancer communications. 3(3)
Starting with the V79 cell line, two poly(ADP-ribose) polymerase deficient mutants, designated ADPRT 54 and ADPRT 351, had been shown to be hypersensitive to x- and UV-irradiation and to topoisomerase I inhibitors but to be resistant to topoisomerase