Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Hiroshi Sugiyama"'
Autor:
Soyoung Park, Hiroshi Sugiyama
Publikováno v:
Molecules, Vol 17, Iss 11, Pp 12792-12803 (2012)
DNA as a Chiral Scaffold for Asymmetric Synthesis
Externí odkaz:
https://doaj.org/article/f15fca8e168b4468a1ca5cad3f0d4345
Publikováno v:
Chemistry – A European Journal. 29
Förster resonance energy transfer (FRET) is an attractive tool for understanding biomolecular dynamics. FRET-based analysis of nucleosomes has the potential to fill the knowledge gaps between static structures and dynamic cellular behaviors. Compare
Autor:
Shengtao Yao, Yongyun Chang, Zanjing Zhai, Hiroshi Sugiyama, Masayuki Endo, Weiping Zhu, Yufang Xu, Yangyang Yang, Xuhong Qian
Publikováno v:
ACS Applied Materials & Interfaces. 14:20739-20748
Interlocked DNA nanostructures perform programmable movements in nanoscales such as sliding, contraction, and expansion. However, utilizing nanoscaled interlocked movements to regulate the functions of larger length scaled matrix and developing their
Autor:
Sagun Jonchhe, Shankar Pandey, Christian Beneze, Tomoko Emura, Hiroshi Sugiyama, Masayuki Endo, Hanbin Mao
Publikováno v:
Nucleic Acids Research
Both ligand binding and nanocavity can increase the stability of a biomolecular structure. Using mechanical unfolding in optical tweezers, here we found that a DNA origami nanobowl drastically increased the stability of a human telomeric G-quadruplex
Autor:
Hiroshi Sugiyama, Ryu Tashiro
Publikováno v:
Photochem Photobiol
5-Halouracil, which is a DNA base analog in which the methyl group at the C5 position of thymine is replaced with a halogen atom, has been used in studies of DNA damage. In DNA strands, the uracil radical generated from 5-halouracil causes DNA damage
Publikováno v:
Bioconjugate Chemistry. 32(10):2129-2133
Phase transition is a promising aspect of DNA as biopolymers. Anionic DNA oligonucleotides easily form complexes with cationic polypeptides such as polylysine, and duplex formation significantly influences their complexation and resulting microcompar
Publikováno v:
Angewandte Chemie International Edition. 60(37):20342-20349
The extracellular matrix (ECM) in which the cells reside provides a dynamic and reversible environment. Spatiotemporal cues are essential when cells are undergoing morphogenesis, repair and differentiation. Emulation of such an intricate system with
Autor:
Yu Jin, Jaeyoung Bae, Tehee Yurie Kim, Hyeseung Hwang, Taesoo Kim, Myungheon Yu, Hyesoo Oh, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama, Kyubong Jo
Publikováno v:
Analytical chemistry. 94(48)
Streptavidin-fluorescent proteins (SA-FPs) are a versatile tool to visualize a broad range of biochemical applications on a fluorescence microscope. Although the avidin-biotin interaction is widely used, the use of SA-FPs has not been applied to sing
Autor:
Shankar Pandey, Sagun Jonchhe, Shubham Mishra, Tomoko Emura, Hiroshi Sugiyama, Masayuki Endo, Hanbin Mao
Publikováno v:
The journal of physical chemistry letters. 13(37)
Cellular environments such as nanoconfinement and molecular crowding can change biomolecular properties. However, in nanoconfinement, it is extremely challenging to investigate effects of crowding cosolutes on macromolecules. By using optical tweezer
Publikováno v:
Bulletin of the Chemical Society of Japan. 94:1948-1953
G-quadruplex (G4) is the most well-known noncanonical conformation of DNA involved in diverse pharmacological and biological contexts. G4 ligands have been actively developed as molecular probes and tumor therapeutic reagent candidates. They have als