Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Christopher L. Moertel, Amanda L. Halfond, Adrienne L. Watson, Eric P. Rahrmann, David A. Largaespada, Leah K. Anderson, Kyle A. Williams, Andrew D. Greeley, Natasha M. Powell, Namrata N. Damle, Vincent W. Keng, Tilat A. Rizvi, Bryant J. Keller, Margaret H. Collins, Samuel J. Finnerty, Nancy Ratner
Publikováno v:
Oncotarget
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that occur spontaneously, or from benign plexiform neurofibromas, in the context of the genetic disorder Neurofibromatosis Type 1 (NF1). The current standard treatment include
Autor:
Amy P, Chiu, Vincent W, Keng
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1907
Understanding the complex genetic background of cancers is key in developing effective targeted therapies. The Sleeping Beauty (SB) transposon system is a powerful and unbiased genetic editing tool that can be used for rapid screening of candidate li
Autor:
Xiao-Xiao, Li, Shi-Jie, Zhang, Amy P, Chiu, Lilian H, Lo, Jian, Huang, Dewi K, Rowlands, Jinhui, Wang, Vincent W, Keng
Publikováno v:
Cancer medicine. 7(9)
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. MPNSTs can occur either sporadically or in association with the neuro
Autor:
Adam J. Dupuy, Barbara R. Tschida, Vincent W. Keng, David A. Largaespada, Khalid Amin, Christopher S. Stipp, Pauline J. Beckmann, Charlotte R. Feddersen, Michael A. Linden, Jesse D. Riordan
Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation or influences selective pressures for genetic drivers of HCC remains unclear. We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e536d52d60f1ab77cc1c53064e4ec808
https://europepmc.org/articles/PMC5826818/
https://europepmc.org/articles/PMC5826818/
Autor:
Eric B. Schwartz, Walter J. Jessen, Jianqiang Wu, James R. Fuchs, Yuanshu Zou, Kevin A. T. Silverstein, Jose A. Cancelas, Deanna M. Patmore, Kwangmin Choi, Mi-Ok Kim, Edwin Jousma, Ami V. Patel, David A. Largaespada, Eva Dombi, Gang Huang, Barbara R. Tschida, David E. Levy, Jed J. Kendall, Vincent W. Keng, Robert J. Spinner, Danhua Fan, Nancy Ratner, Anat Stemmer-Rachamimov
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1979-1990 (2016)
SummaryTo identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4cd23be8f1a14cb8ed8e1e19cb857a
https://europepmc.org/articles/PMC4782770/
https://europepmc.org/articles/PMC4782770/
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer
Autor:
Jef D. Boeke, Wei Rose Xie, Erin L. Reineke, Bert W. O'Malley, David A. Largaespada, Vincent W. Keng, Loris Mularoni, Michael Torbenson, Danhua Fan, Kathryn A. O'Donnell, Sarah J. Wheelan, Brian York, Kevin A. T. Silverstein, Christina T. Schrum, Daekwan Seo
The Sleeping Beauty ( SB ) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC , one of the most commonly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd78fe674776140ab4f45b3df0b55f4d
https://europepmc.org/articles/PMC3361419/
https://europepmc.org/articles/PMC3361419/
Autor:
Lilian H. Lo, David A. Largaespada, Barbara R. Tschida, Amy P. Chiu, Dewi K Rowlands, Branden S. Moriarity, Vincent W. Keng
Publikováno v:
World Journal of Gastroenterology. 21:12157
The major type of human liver cancer is hepatocellular carcinoma (HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepat