Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael M. Shen"'
Autor:
Cory Abate-Shen, Amir Lankarani, Matteo Di Bernardo, Michael M. Shen, Rivka L. Shoulson, Soonbum Park, Lijie Rong, Tomasz Owczarek, Talal Syed, Hikmat Al-Ahmadie, David B. Solit, James M. McKiernan, Chee-Wai Chua, Prithi Chakrapani, Jaime Y. Kim
Publikováno v:
Cancer Res
To study the progression of bladder cancer from non–muscle-invasive to muscle-invasive disease, we have developed a novel toolkit that uses complementary approaches to achieve gene recombination in specific cell populations in the bladder urotheliu
Autor:
Michael M. Shen, Weiping Li
Publikováno v:
Semin Cancer Biol
Although prostate adenocarcinoma lacks distinguishable histopathological subtypes, prostate cancer displays significant inter- and intratumor heterogeneity at the molecular level and with respect to disease prognosis and treatment response. In princi
Autor:
Min Zou, Andrea Califano, Michael Michael M Shen, Antonina Mitrofanova, Cory Abate-Shen, Alvaro Aytes
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2060-2071 (2015)
SummaryAlthough genetically engineered mouse (GEM) models are often used to evaluate cancer therapies, extrapolation of such preclinical data to human cancer can be challenging. Here, we introduce an approach that uses drug perturbation data from GEM
Autor:
Suk Hyung Lee, Hikmat Al-Ahmadie, Alanna B. Williams, James M. McKiernan, Cory Abate-Shen, Wenhuo Hu, Mitchell C. Benson, Mark V. Silva, Barry S. Taylor, Kwanghee Kim, Eugene J. Pietzak, Sarah K. Bergren, La Mont J. Barlow, Christopher B. Anderson, Jonathan A. Coleman, Cyriac Kandoth, David B. Solit, Michael M. Shen, Justin T. Matulay, Chee Wai Chua, Tomasz Owczarek
Publikováno v:
Cell. 173(2)
Summary Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulate
Autor:
Cory Abate-Shen, Clémentine Le Magnen, Min Zou, Antonina Mitrofanova, Andrea Califano, Nicolas Floc'h, Yanping Sun, Mark A. Rubin, Elahe A. Mostaghel, Sheida Hayati, Michael M. Shen, Roxanne Toivanen, Daniel Chester
Publikováno v:
Cancer discovery. 7(7)
Current treatments for castration-resistant prostate cancer (CRPC) that target androgen receptor (AR) signaling improve patient survival, yet ultimately fail. Here, we provide novel insights into treatment response for the antiandrogen abiraterone by
Autor:
Urmila Santanam, Whitney Banach-Petrosky, Michael M. Shen, Cory Abate-Shen, Eileen White, Robert S. DiPaola
Publikováno v:
Genesdevelopment. 30(4)
Understanding new therapeutic paradigms for both castrate-sensitive and more aggressive castrate-resistant prostate cancer is essential to improve clinical outcomes. As a critically important cellular process, autophagy promotes stress tolerance by r
Autor:
Victor E. Reuter, Cory Abate-Shen, Angel M. Serio, Peter T. Scardino, Hikmat Al-Ahmadie, Walter J. Jessen, Xuesong Ouyang, William L. Gerald, Yong Lin, Andrew J. Vickers, Bruce J. Aronow, Weichung-Joseph Shih, Michael M. Shen
Publikováno v:
Cancer Research. 68:2132-2144
To identify biomarkers that discriminate the aggressive forms of prostate cancer, we performed gene expression profiling of prostate tumors using a genetically engineered mouse model that recapitulates the stages of human prostate cancer, namely Nkx3
Autor:
Michael M, Shen
Publikováno v:
Nature. 520(7547)
Autor:
William L. Gerald, Michael M. Shen, Cory Abate-Shen, Hui Gao, Whitney Banach-Petrosky, Xuesong Ouyang
Publikováno v:
Proceedings of the National Academy of Sciences. 103:14477-14482
Androgen independence is responsible for most prostate cancer lethality, yet currently there are no effective clinical treatments. We have been investigating the mechanisms underlying androgen-independent prostate cancer in Nkx3.1;Pten mutant mice, w
Autor:
Jae-Hak Park, Judy Walls, Cory Abate-Shen, Minjung Kim, Jose J. Galvez, Michael M. Shen, Robert D. Cardiff
Publikováno v:
The American Journal of Pathology. 161:727-735
Several mouse models of human prostate cancer were studied to identify and characterize potential precursor lesions containing foci of atypical epithelial cells. These lesions exhibit a sequence of changes suggesting progressive evolution toward mali