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Autor:
Richard S. Eisenstein, James A Votava, Arjang Djamali, Shannon R. Reese, Sheila A. Anderson, Kathryn M. Deck, Christopher P. Nizzi
Publikováno v:
Am J Physiol Renal Physiol
Chronic kidney disease involves disturbances in iron metabolism including anemia caused by insufficient erythropoietin (EPO) production. However, underlying mechanisms responsible for the dysregulation of cellular iron metabolism are incompletely def
Autor:
Daniel E. Rivera, Núria M. Pastor-Soler, Pei-Yin Ho, Valeria Mancino, Jessica Pham, Hui Li, Biagio Saitta, Kenneth R. Hallows
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F27-F41
Metformin treatment improved ADPKD disease severity in a relevant, slowly progressive ADPKD mouse model that recapitulates a PKD-associated PKD1 mutation. Relative to controls, metformin reduced kidney weight/body weight, cystic index and BUN levels,
Autor:
Huijing Zhu, Li Yan, Weiqi Min, Ruihuan Zhang, Yiheng Chen, Ying Li, Min Cai, Jun Wang, Chunhua Wang
Publikováno v:
Current Topics in Medicinal Chemistry. 21:2425-2433
Background and Objective: Osteoporosis is a worldwide healthcare challenge. Conventional medications for osteoporosis prevention are not clinically effective or associated with gastrointestinal tract adverse effects. The present study aimed to compar
Autor:
Atsushi Hoshino, Shunta Taminishi, Yoshito Minami, Satoaki Matoba, Ryota Urata, Tomohiro Hino, Takashi Nakagawa, Yohei Fushimura, Eri Iwai-Kanai, Satoru Furukawa
Publikováno v:
Biochemical and Biophysical Research Communications. 585:191-195
Impairment of pancreatic β cells is a principal driver of the development of diabetes. Restoring normal insulin release from the β cells depends on the ATP produced by the intracellular mitochondria. In maintaining mitochondrial function, the tumor
Autor:
Keith L. Kirkwood, Yanchun Li, Lixia Zhang, Cameron L. Kirkwood, Yan Huang, Maria F. Lopes-Virella, Zhongyang Lu
Publikováno v:
J Periodontal Res
Background and objective Clinical studies have shown that metabolic syndrome (MetS) exacerbates periodontitis. However, the underlying mechanisms remain largely unknown. Since our animal study has shown that high-fat diet-induced MetS exacerbates lip
Autor:
L. Pivackova, Jan Klimas, Zuzana Kmecova, Eva Velasova, Peter Krenek, E. Malikova, Simona Trubacova, Peter Balis, Gabriel Doka
Publikováno v:
Clinical and Experimental Hypertension. 44:101-112
Background Caveolin-1 (cav-1) plays a role in pulmonary arterial hypertension (PAH). Monocrotaline (MCT)-induced PAH is characterized by a loss of cav-1 in pulmonary arteries; however, less is known regarding its role in the hypertrophied right ventr
Autor:
Katsuhiko Amano, Kenji Sueishi, Masashi Nagao, Yoichi Ishizuka, Akira Watanabe, Takenobu Ishii, Tomohisa Ootake, Yasushi Nishii, Kazuaki Nishimura
Publikováno v:
Osteoarthritis and Cartilage. 29:1575-1589
Summary Objective To observe and analyze the interaction between excessive mechanical stress (MS) and decreased sex hormones on Temporomandibular Joint Osteoarthritis (TMJ-OA), and to discover TMJ-OA disease susceptibility genes by molecular biologic
Autor:
Eunju Leem, Hyung-Jun Kim, Youngpyo Nam, Won-Ho Shin, Sang Ryong Kim, Chang-Won Hong, Sehwan Kim, Byung Kwan Jin, Chanchal Sharma, Kyu-Sung Kim, Dong Woon Kim, Shinrye Lee, Catriona McLean, Do-Geun Kim, Jaekwang Kim, Gyeong Joon Moon, Chang Man Ha, Yong-Seok Oh
Publikováno v:
British Journal of Pharmacology. 179:998-1016
BACKGROUND AND PURPOSE There is a scarcity of information regarding the role of prothrombin kringle-2 (pKr-2), which can be generated by active thrombin, in hippocampal neurodegeneration and Alzheimer's disease (AD). EXPERIMENTAL APPROACH To assess t
Autor:
Marcella de Amorim Ferreira, Geisson Marcos Nardi, Thiele Osvaldt Rosales, Jamil Assreuy, Verônica Vargas Horewicz
Publikováno v:
Clinical Science. 135:2341-2356
Renal vascular reactivity to vasoconstrictors is preserved in sepsis in opposition to what happens in the systemic circulation. We studied whether this distinct behavior was related to α1 adrenergic receptor density, G protein-coupled receptor kinas
Autor:
Yan Lu, Christopher A. Vuong, Hongying Peng, Nicolas G. Bazan, Song Hong, Nicholas B. Pham, Quoc-Viet A. Duong, Aarti Nagayach
Publikováno v:
CNS Neuroscience & Therapeutics
Aims To explore the novel linkage between a Western diet combining high saturated fat, sugar, and salt (HFSS) and neurological dysfunctions during aging as well as Metformin intervention, we assessed cerebral cortex abnormalities associated with sens