Zobrazeno 1 - 10
of 82
pro vyhledávání: '"R. Wands"'
Autor:
Shu Shimada, Kaoru Mogushi, Yoshimitsu Akiyama, Takaki Furuyama, Shuichi Watanabe, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Minoru Tanabe, Jack R. Wands, Shinji Tanaka
Publikováno v:
EBioMedicine, Vol 40, Iss, Pp 457-470 (2019)
Background: Hepatocellular carcinoma (HCC) is a heterogeneous disease with various etiological factors, and ranks as the second leading cause of cancer-related mortality worldwide due to multi-focal recurrence. We herein identified three major subtyp
Autor:
Jack R. Wands, Yusuke Mitsunori, Daisuke Ban, Toshiro Ogura, Takaki Furuyama, Kaoru Mogushi, Shigeki Arii, Shinji Tanaka, Shu Shimada, Hiroaki Ono, Yoshimitsu Akiyama, Kosuke Ogawa, Minoru Tanabe, Shuichi Watanabe, Atsushi Kudo
Publikováno v:
EBioMedicine
Background Hepatocellular carcinoma (HCC) is a heterogeneous disease with various etiological factors, and ranks as the second leading cause of cancer-related mortality worldwide due to multi-focal recurrence. We herein identified three major subtype
Autor:
Songhua Zhang, Jack R. Wands, Steve Fuller, Zhi-Gang Jiang, Katsuya Nagaoka, Xuewei Bai, Kosuke Ogawa, Rolf I. Carlson, Hossein A. Ghanbari, Yanmei Zhou, Xiaoqun Dong, Michael S. Lebowitz
Publikováno v:
Cancer Lett
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with very limited treatment options. Antibody drug conjugates (ADCs) are promising cytotoxic agents capable of highly selective delivery. Aspartate-β-hydroxylase (ASPH) is
Autor:
Carina Preskill, Kwang Hyub Han, Shuping Tong, Sang Hoon Ahn, Dina Gewaily, Jack R. Wands, Huailiang Zhou, Yongxiang Wang, Jisu Li, Li Zong, Jing Zhang
This study aimed to identify and characterize mutations in the hepatitis B virus (HBV) genome associated with advanced liver diseases. The 3.2-kb HBV genome of the C2 subgenotype was amplified from sera of 18 cirrhotic Korean patients with (10) or wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c84206322729e62a149667388c330e
https://europepmc.org/articles/PMC6372094/
https://europepmc.org/articles/PMC6372094/
Autor:
Yanli Qin, Shuping Tong, Jisu Li, Haodi Jia, Jack R. Wands, Lei Ye, Jiming Zhang, Yongxiang Wang, Li Zong
Hepatitis B virus (HBV) transcribes two subsets of 3.5-kb RNAs: precore RNA for hepatitis B e antigen (HBeAg) expression, and pregenomic RNA for core and P protein translation as well as genome replication. HBeAg expression could be prevented by muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a3b9f604fb997c2a87cc8991a6c4e8
https://europepmc.org/articles/PMC5391676/
https://europepmc.org/articles/PMC5391676/
Publikováno v:
Emerging Microbes & Infections
Hepatitis B virus (HBV) causes a chronic infection in 350 million people worldwide and greatly increases the risk of liver cirrhosis and hepatocellular carcinoma. The majority of chronic HBV carriers live in Asia. HBV can be divided into eight genoty
Cell culture (cc)-derived hepatitis B virus (HBV) can infect differentiated HepaRG cells, but efficient infection requires addition of polyethylene glycol (PEG) during inoculation. Identification of sodium taurocholate cotransporting polypeptide (NTC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa869befec8d67d578c9cbe15f6d1ea
https://europepmc.org/articles/PMC5008102/
https://europepmc.org/articles/PMC5008102/
Autor:
Betty L. Slagle, Miran Kim, Waihong Chung, Jack R. Wands, Rolf I. Carlson, Lisa Longato, Xiaoqun Dong, Suzanne M. de la Monte
Background and aims Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. Methods Liver specific expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eca54cd652a9d7bc6da8f87fdc4b18
https://europepmc.org/articles/PMC4684747/
https://europepmc.org/articles/PMC4684747/
Autor:
David E. Kleiner, Heather M. Niemeier, Kittichai Promrat, Joseph L. Fava, Jack R. Wands, Elizabeth H. Jackvony, Marie Kearns, Rena R. Wing
Publikováno v:
Hepatology. 51:121-129
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by accumulation of fat in the liver accompanied by necroinflammation and hepatocellular injury(1). Despite being one of the most common chronic liver diseases in the U.S., t
Autor:
Xiang-Hui Wu, Richeng Mao, Hongying Guo, Yanli Qin, Shuping Tong, Jack R. Wands, You-Kuan Yin, Jiming Zhang, Xin-Hua Weng
Publikováno v:
Journal of Medical Virology. 81:807-814
The A1762T and G1764A mutations in the basal core promoter (BCP) region and the G1896A mutation in the precore (PC) region of hepatitis B virus (HBV) genome are found commonly in HBeAg-negative patients. Experiments in vitro suggest that BCP and PC m