Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Agnieszka Wozniak"'
Autor:
Olli Kallioniemi, Markku Varjosalo, Katherine Icay, John Patrick Mpindi, Olli Tynninen, Sampsa Hautaniemi, Agnieszka Wozniak, Astrid Murumägi, Evgeny Kulesskiy, Pirjo Laakkonen, Yemarshet K. Gebreyohannes, Maria Laaksonen, Rainer Lehtonen, Heikki Joensuu, Olli-Pekka Pulkka, Krister Wennerberg, Harri Sihto, Salla Keskitalo, Patrick Schöffski, Alejandra Cervera
Publikováno v:
Clinical Cancer Research. 25:1676-1687
Purpose: Gastrointestinal stromal tumor (GIST) is a common type of soft-tissue sarcoma. Imatinib, an inhibitor of KIT, platelet-derived growth factor receptor alpha (PDGFRA), and a few other tyrosine kinases, is highly effective for GIST, but advance
Publikováno v:
Expert review of anticancer therapy. 17(12)
The majority of gastrointestinal stromal tumors (GIST) are driven by an abnormal receptor tyrosine kinase (RTK) signaling, occurring mainly due to somatic mutations in KIT or platelet derived growth factor receptor alpha (PDGFRA). Although the introd
Autor:
Erik A.C. Wiemer, Patrick Schöffski, Antonius W. M. Boersma, Stefan Sleijfer, Caroline M.M. Gits, Ron H.J. Mathijssen, Moniek B E Jonkers, W F J van IJcken, Agnieszka Wozniak, Piotr Rutkowski, P F van Kuijk, Raf Sciot, Jaap Verweij, Takahiro Taguchi, Maria Debiec-Rychter
Publikováno v:
British Journal of Cancer, 109(6), 1625-1635. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer
BACKGROUND: Gastrointestinal stromal tumours (GIST) are characterised by high expression of KIT and ETV1, which cooperate in GIST oncogenesis. Our aim was to identify microRNAs that are deregulated in GIST, have a role in GIST pathogenesis, and could
Promoting role of cholecystokinin 2 receptor (CCK2R) in gastrointestinal stromal tumour pathogenesis
Autor:
Barbara Dewaele, Maria Debiec-Rychter, Marijke Bauters, Patrick Schöffski, Vanessa Vanspauwen, Anna Quattrone, Raf Sciot, Frédéric Chibon, Agnieszka Wozniak, Giuseppe Floris, Jean-Michel Coindre
Publikováno v:
The Journal of Pathology. 228:565-574
The cholecystokinin 2 receptor (CCK2R/CCKBR) is expressed in gastrointestinal stromal tumours (GISTs). We sought to investigate the role of CCK2R in GIST pathogenesis. Molecular characterization of CCK2R was performed on a heterogeneous cohort of 50
Autor:
Agnieszka Wozniak, Liesbet van Eycken, Maria Debiec-Rychter, Oliver Schöffski, Patrick Schöffski
Publikováno v:
Oncology research and treatment. 39(12)
Background: Genetic analysis of tissue derived from patients with advanced gastrointestinal stromal tumors (GISTs) is not uniformly applied on a national and international level, even though mutational data can provide clinically relevant prognostic
Autor:
Jasmien Wellens, Patrick Schöffski, Maria Debiec-Rychter, Gavino Faa, Emmanuel Normant, Agnieszka Wozniak, Thomas Van Looy, Giuseppe Floris, Raf Sciot
Publikováno v:
Clinical Cancer Research. 17:5604-5614
Purpose: KIT activity is crucial for gastrointestinal stromal tumors (GIST). Imatinib (IMA) and sunitinib (SUN) are very effective KIT-inhibitors in patients with advanced GIST but have no curative potential. We evaluated the efficacy of the novel HS
Autor:
Peter Marynen, Jan Cools, Peter Vandenberghe, Agnieszka Wozniak, Raphael Sciot, Barbara Dewaele, Maria Debiec-Rychter, Patrick Schöffski, Bartosz Wasag, Hans Prenen
Publikováno v:
Clinical cancer research
Purpose: Activating mutations in platelet-derived growth factor receptor-α (PDGFRA) have been reported in ∼5% to 10% of patients with gastrointestinal stromal tumors (GIST). Imatinib efficiently inhibits the juxtamembrane PDGFRA mutations, whereas
Autor:
Agnieszka Wozniak, Eva Wardelmann, Michael Heinrich, Jerzy Lasota, Javier Garcia Del Muro, Maria Debiec-Rychter, Cristina R. Antonescu, Sabine Merkelbach-Bruse, Ondrej Daum, Hans Ulrich Schildhaus, Jerzy Stachura, Markku Miettinen, Sonja E. Steigen, Raf Sciot, Javier Martin, Christopher L. Corless
Publikováno v:
Modern Pathology. 21:476-484
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms driven by oncogenic, mutational activation of KIT or platelet-derived growth factor receptor alpha (PDGFRA). GIST-specific KIT or PDGFRA mutations have been linked to tumor location, t
Autor:
Agnieszka Dansonka-Mieszkowska, Jerzy Stachura, Marrit Sarlomo-Rikala, Regine Schneider-Stock, Janusz Kopczyński, Jerzy Lasota, Janusz Limon, Tomoko Mitsuhashi, Jeffrey R. Lee, Agnieszka Wozniak, Bartek Wasag, Markku Miettinen
Publikováno v:
Laboratory Investigation. 85:237-247
Mutational activation of KIT or PDGFRA is considered an early step in pathogenesis of gastrointestinal stromal tumors (GISTs); however, other nonrandom genetic changes have also been identified. At least three common regions of deletions on chromosom
Autor:
Thomas Van Looy, Raf Sciot, Jasmien Cornillie, Haifu Li, Giuseppe Floris, Maria Debiec-Rychter, Patrick Schöffski, Yemarshet K. Gebreyohannes, Jasmien Wellens, Agnieszka Wozniak, Ulla Vanleeuw
Publikováno v:
Clinical Sarcoma Research
Background Acquired resistance to tyrosine kinase inhibitors (TKIs) in gastrointestinal stromal tumours (GISTs) is most commonly caused by secondary KIT or PDGFRA mutations. In this study we characterize a newly established GIST xenograft model, UZLX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58049c019906ec8f5e468c28a5383787