Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Fay, K"'
Autor:
John K. Fallon, Saber H. Maleki, Philip C. Smith, Joseph K. Ritter, Fay K. Kessler, David E. Harbourt
Publikováno v:
Drug Metabolism Letters. 2:210-222
UGT enzymes catalyze the formation of glucuronic acid conjugates. Specifically selected representative stable isotope (C(13), N(15)) labeled peptide internal standards of each enzyme were employed to quantify UGTs 1A1 and 1A6 by LC-MS/MS using isotop
Autor:
Kristini K. Miles, Judith N. Nielsen, Philip C. Smith, Melanie N. Tallman, Fay K. Kessler, Xianbin Tian, Joseph K. Ritter
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:29-37
Life-threatening diarrhea afflicts a considerable percentage of patients treated with irinotecan, an anticancer agent with effects elicited through its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). The primary detoxification pathway for S
Publikováno v:
Drug Metabolism and Disposition. 30:324-330
Gunn rats glucuronidate acetaminophen (APAP) at reduced rates and show increased susceptibility to APAP-induced hepatotoxicity. This defect is presumed to involve UDP-glucuronosyltransferase (UGT) 1A6, which is nonfunctional in Gunn rats, but it is c
Autor:
Diana J. Auyeung, Fay K. Kessler, Andrew D. Grove, Robert A. Fisher, Melissa T. Thompson, Joseph K. Ritter
Publikováno v:
Hepatology. 30:476-484
In Crigler-Najjar type II patients and, recently, in Crigler-Najjar type I patients treated with human hepatocyte cell therapy, phenobarbital has been used for reducing the serum bilirubin load. Its effect is attributed to induction of the enzyme req
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 34(9)
Mycophenolic acid (MPA) is the active immunosuppressive metabolite of the anti-organ rejection drug mycophenolate mofetil (MMF) and is implicated in the gastrointestinal toxicity associated with MMF therapy. Intestinal UDP-glucuronosyltransferases (U
Publikováno v:
Environmental toxicology and pharmacology. 21(3)
Four UDP-glucuronosyltransferases from the rat UGT1A family were tested for activity towards benzo[a]pyrene phenols and dihydrodiols. UGT1A1 and UGT1A7 were found to be broadly active towards BaP metabolites. Antisera recognizing rat UGT1A1 and UGT1A
Autor:
Jayanta Roy Chowdhury, Namita Roy Chowdhury, Philip A. Gregory, Peter G. Wells, Antony J. Hansen, Fay K. Kessler, Joseph K. Ritter, Peter I. Mackenzie, Yuji Ishii, Perry M. Kim, Chantal Guillemette
Publikováno v:
Flinders University PURE
This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecul
Publikováno v:
Toxicology and applied pharmacology. 174(1)
UDP-glucuronosyltransferase 1A6 (UGT1A6), a key enzyme catalyzing the glucuronidation of small planar phenols and amines, is expressed in a tissue- and inducer-dependent manner. Expression is high in kidney, gastrointestinal tract, and induced liver,
Autor:
Fay K. Kessler, Joseph K. Ritter
Publikováno v:
Carcinogenesis. 18(1)
We report here that rats possess a hitherto unrecognized xenobiotic-inducible hepatic 7,8-dihydro-7,8-diol-benzo[a]pyrene (BPD) UDP-glucuronosyltransferase (UGT) activity. BPD UGT activity is induced in female F344 rat liver by treatment with the sel