Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anita, Balakrishnan"'
Publikováno v:
Digestive Diseases and Sciences. 57:1525-1536
The intestine demonstrates profound circadian rhythmicity in glucose absorption in rodents, mediated entirely by rhythmicity in the transcription, translation, and function of the sodium glucose co-transporter SGLT1 (Slc5a1). Clock genes are rhythmic
Publikováno v:
Annals of Surgery. 251:865-871
We set out to examine the short-term regulation of the intestinal sodium/glucose cotransporter SGLT1 by its substrate glucose and sweet taste analogs.Intestinal SGLT1 is a putative target for antidiabetic therapy; however, its physiological regulatio
Publikováno v:
The Journal of Nutrition. 140:908-914
The intestine exhibits striking diurnal rhythmicity in glucose uptake, mediated by the sodium glucose cotransporter (SGLT1); however, regulatory pathways for these rhythms remain incompletely characterized. We hypothesized that SGLT1 rhythmicity is l
Publikováno v:
Surgery. 144:168-173
The sodium glucose cotransporter (SGLT1) is responsible for all active intestinal glucose uptake. Hepatocyte nuclear factors 1 alpha and beta (HNF 1 alpha and HNF 1 beta) activate the SGLT1 promoter, whereas GATA-binding protein 5 (GATA-5) and caudal
Autor:
Ali Tavakkolizadeh, A. Radmanesh, Anita Balakrishnan, David B. Rhoads, Adam T. Stearns, Stanley W. Ashley
Publikováno v:
Digestive diseases and sciences. 57(5)
We previously demonstrated vagal neural pathways, specifically subdiaphragmatic afferent fibers, regulate expression of the intestinal sodium-glucose cotransporter SGLT1, the intestinal transporter responsible for absorption of dietary glucose. We hy
Publikováno v:
Surgery. 145(3)
The intestinal sodium-glucose cotransporter 1 (SGLT1) is responsible for all secondary active transport of dietary glucose, and it presents a potential therapeutic target for obesity and diabetes. SGLT1 expression varies with a profound diurnal rhyth
Autor:
Ali Tavakkolizadeh, Adam T. Stearns, Jan D. Rounds, Anita Balakrishnan, David B. Rhoads, Stanley W. Ashley
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 294(4)
Introduction: the intestinal Na+/glucose cotransporter (SGLT1) displays rapid anticipatory diurnal rhythms in mRNA and protein expression. The vagus nerve has been implicated in the entrainment of some transporters. We aimed to clarify the influence
Autor:
Jennifer Irani, Michael J. Giuffrida, Jan D. Rounds, Anita Balakrishnan, David B. Rhoads, Adam T. Stearns, Ali Tavakkolizadeh, Stanley W. Ashley
Publikováno v:
Surgery. 143(6)
Intestinal transport exhibits distinct diurnal rhythmicity. Understanding the mechanisms behind this may reveal new therapeutic strategies to modulate intestinal function in disease states such as diabetes and obesity, as well as short bowel syndrome