Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Richard H. Gomer"'
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Human macrophages and the eukaryotic microbe Dictyostelium discoideum ingest bacteria by phagocytosis, and then kill the ingested bacteria. Some pathogenic bacteria secrete linear chains of phosphate residues (polyphosphate; polyP), and the
Externí odkaz:
https://doaj.org/article/5b7961016a1c47cb8a6b75fb8e1fb8a8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5923 (2023)
Dictyostelium discoideum is a soil-dwelling unicellular eukaryote that accumulates extracellular polyphosphate (polyP). At high cell densities, when the cells are about to overgrow their food supply and starve, the corresponding high extracellular co
Externí odkaz:
https://doaj.org/article/6c0e112e504c4dc99be0a0d3fce06d23
Autor:
Yu Tang, Yuantai Wu, Sarah E. Herlihy, Francisco J. Brito-Aleman, Jose H. Ting, Chris Janetopoulos, Richard H. Gomer
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT In eukaryotic microbes, little is known about signals that inhibit the proliferation of the cells that secrete the signal, and little is known about signals (chemorepellents) that cause cells to move away from the source of the signal. Autoc
Externí odkaz:
https://doaj.org/article/7addfcf8d05948fa8ec34887df7d8be0
Autor:
Jonathan E. Phillips, Richard H. Gomer
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 2, Pp 147-156 (2015)
Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment available. Children with NCL show a progressive decline in movement, vision and mental abi
Externí odkaz:
https://doaj.org/article/2b5642a2ed7c4557815e0cc125702cbd
Publikováno v:
Journal of Cell Science. 135
Dictyostelium discoideum is a unicellular eukaryote that eats bacteria, and eventually outgrows the bacteria. D. discoideum cells accumulate extracellular polyphosphate (polyP), and the polyP concentration increases as the local cell density increase
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(2)
A considerable amount is known about how eukaryotic cells move toward an attractant, and the mechanisms are conserved from Dictyostelium discoideum to human neutrophils. Relatively little is known about chemorepulsion, where cells move away from a re
Autor:
Sara A. Kirolos, Richard H. Gomer
Publikováno v:
Molecular biology of the cell. 33(1)
The ability of cells to sense chemical gradients is essential during development, morphogenesis, and immune responses. Although much is known about chemoattraction, chemorepulsion remains poorly understood. Proliferating Dictyostelium cells secrete a
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Acute respiratory distress syndrome (ARDS) involves damage to lungs causing an influx of neutrophils from the blood into the lung airspaces, and the neutrophils causing further damage, which attracts more neutrophils in a vicious cycle. There are ∼
Autor:
Louis A. Cadena, Jacquelyn R. McCullough, David E. Zimmerhanzel, Richard H. Gomer, Ramesh Rijal, Yu Tang
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
mBio
mBio
Little is known about how eukaryotic cells can sense their number or spatial density and stop proliferating when the local density reaches a set value. We previously found that Dictyostelium discoideum accumulates extracellular polyphosphate to inhib
Autor:
Richard H. Gomer, Yu Tang
Publikováno v:
Biotechniques
Shotgun expression of antisense cDNA, where each transformed cell expresses a different antisense cDNA, has been used for mutagenesis and gene identification in Dictyostelium discoideum. However, the method has two limitations. First, there were too