Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Stringham, Hm"'
Autor:
Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Jiang L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Ulrich A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Zudina L; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., González KSG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica., Balkhiyarova Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK., Faggian A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Maina JG; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Chen S; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Todorov PV; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Sharapov S; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., David A; Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK., Marullo L; Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rujan RM; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Ahlqvist E; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Gao Η; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Εvangelou Ε; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Benyamin B; Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.; Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Isaacs A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Zhao JH; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Willems SM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson T; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Meisinger C; Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; School of Health and Wellbeing, University of Glasgow, Glasgow, UK., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Corrêa IR Jr; New England Biolabs, Ipswich, MA, USA., Farber-Eger E; Vanderbilt Institute for Clinical and Translational Research and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Schmidberger J; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hveem K; K G Jebsen Centre for Genetic Epdiemiology, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Shmeliov A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., den Hoed M; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Haenle M; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore and Department of Endocrinology, Tan Tock Seng Hospital, Singapore City, Singapore., Tan TM; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Tomas A; Section of Cell Biology and Functional Genomics, Imperial College London, London, UK., Salem V; Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter, UK., Tuomilehto J; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Unit, King Abdulaziz University, Jeddah, Saudi Arabia., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Florez JC; Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Wichmann HE; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium for Healthy Ageing, the Hague, the Netherlands., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Whitfield JB; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Montgomery G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Tzoulaki I; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, Imperial College London, London, UK.; National Institute for Health Research Imperial College London Biomedical Research Centre, Imperial College London, London, UK., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Brittain EL; Vanderbilt University Medical Center and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Froguel P; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Groop L; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Deganutti G; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Demirkan A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Reynolds CA; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.; School of Life Sciences, University of Essex, Colchester, UK., Aulchenko YS; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.kaakinen@imperial.ac.uk.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk., Jones B; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK. ben.jones@imperial.ac.uk., Prokopenko I; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France. i.prokopenko@surrey.ac.uk.
Publikováno v:
Nature genetics [Nat Genet] 2023 Sep; Vol. 55 (9), pp. 1448-1461. Date of Electronic Publication: 2023 Sep 07.
Autor:
Raulerson CK; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Ko A; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Kidd JC; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA., Currin KW; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Brotman SM; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Cannon ME; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Welch RP; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Fuchsberger C; Center for Biomedicine, European Academy of Bolzano/Bozen, University of Lübeck, Bolzano/Bozen 39100, Italy., Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA., Narisu N; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Lusis AJ; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Civelek M; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA., Furey TS; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA., Kuusisto J; Institute of Clinical Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio 70210, Finland., Collins FS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Lin DY; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA., Love MI; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA., Laakso M; Institute of Clinical Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio 70210, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: mohlke@med.unc.edu.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2019 Oct 03; Vol. 105 (4), pp. 773-787. Date of Electronic Publication: 2019 Sep 26.
Autor:
Flannick J; Program in Metabolism, Broad Institute, Cambridge, MA, USA. flannick@broadinstitute.org.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA. flannick@broadinstitute.org.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. flannick@broadinstitute.org.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA. flannick@broadinstitute.org., Mercader JM; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Fuchsberger C; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Udler MS; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA.; Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA., Teslovich TM; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Caulkins L; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Koesterer R; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Barajas-Olmos F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Blackwell TW; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Brody JA; Cardiovascular Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Centeno-Cruz F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Chen L; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Chen S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Contreras-Cubas C; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Córdova E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Cortes M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA., Dolan L; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Drews KL; Biostatistics Center, George Washington University, Rockville, MD, USA., Elliott A; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Floyd JS; Department of Medicine and Epidemiology, University of Washington, Seattle, WA, USA., Gabriel S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Garay-Sevilla ME; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., García-Ortiz H; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Han S; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Heard-Costa NL; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Jackson AU; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland., Kang HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Kelsey M; Biostatistics Center, George Washington University, Rockville, MD, USA., Kim BJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Koistinen HA; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicin, Kuopio University Hospital, Kuopio, Finland., Leader JB; Geisinger Health System, Danville, PA, USA., Linneberg A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Manning AK; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard University, Boston, MA, USA., Marcketta A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Malacara-Hernandez JM; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Martínez-Hernández A; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Matsuo K; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Mayer-Davis E; University of North Carolina Chapel Hill, Chapel Hill, NC, USA., Mendoza-Caamal E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Mohlke KL; Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA., Morrison AC; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ndungu A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ng MCY; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., O'Dushlaine C; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Payne AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pihoker C; Seattle Children's Hospital, Seattle, WA, USA., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Preuss M; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA., Vasan RS; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Preventive Medicine & Epidemiology, Medicine, Boston University School of Medicine, Boston, MA, USA., Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Revilla-Monsalve C; Instituto Mexicano del Seguro Social SXXI, Mexico City, Mexico., Robertson NR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Santoro N; Department of Pediatrics, Yale University, New Haven, CT, USA., Schurmann C; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Soberón X; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Stringham HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Strom TM; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Thameem F; Health Science Center, Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat, Kuwait., Tomlinson B; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Torres JM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tracy RP; Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Biochemistry, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA., van Dam RM; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Vujkovic M; 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Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX, USA.; South Texas Diabetes and Obesity Institute, Brownsville, TX, USA., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bowden DW; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore., Cheng CY; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., de Vries PS; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Duggirala R; Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX, USA.; South Texas Diabetes and Obesity Institute, Brownsville, TX, USA., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Gonzalez C; 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Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore., Tuomi T; Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Tuomilehto J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Aguilar-Salinas CA; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico., Bottinger E; Charles R. 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Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA.; The Mindich Child Health and Development Insititute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK., O'Donnell CJ; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Section of Cardiology, Department of Medicine, VA Boston Healthcare, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA.; Intramural Administration Management Branch, National Heart Lung and Blood Institute, NIH, Framingham, MA, USA., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Pankow J; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Park KS; National Heart and Lung Institute, Cardiovascular Sciences, Imperial College London, London, UK.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Haiman C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Henderson BE; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Tusié-Luna T; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Instituto de Investigaciones Biomédicas, Departamento de Medicina Genómica y Toxicología, Universidad Nacional Autónoma de México, Mexico City, Mexico., Dewey FE; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Baras A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Meitinger T; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Strauch K; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Neuherberg, Germany., Lange L; Department of Medicine, University of Colorado Denver, Aurora, CO, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Zeitler P; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Dabelea D; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA., Abecasis G; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bell GI; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Cox NJ; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Seielstad M; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Blood Systems Research Institute, San Francisco, CA, USA., Sladek R; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Meigs JB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Rotter JI; Department of Pediatrics, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Altshuler D; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA., Burtt NP; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Scott LJ; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Morris AP; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Florez JC; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Publikováno v:
Nature [Nature] 2019 Jun; Vol. 570 (7759), pp. 71-76. Date of Electronic Publication: 2019 May 22.
Autor:
Flannick J; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Agarwala V; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Caulkins L; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Koesterer R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Ma C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Moutsianas L; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McCarthy DJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Perry JRB; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Blackwell TW; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Cingolani P; School of Computer Science, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Tajes JF; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Highland HM; Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hartl C; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Chen H; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., van de Bunt M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Pearson RD; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kumar A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Gamazon ER; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Lee J; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Chen Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Below JE; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Chen P; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Go MJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Parker SCJ; Departments of Computational Medicine & Bioinformatics and Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Varga TV; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Green T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Beer NL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Day-Williams AG; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fingerlin T; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA., Horikoshi M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hu C; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Huh I; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Ikram MK; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Kim BJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kim Y; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Kim YJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kwon MS; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Lee J; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Lee S; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Lin KH; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Maxwell TJ; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nagai Y; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Welch RP; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Yoon J; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK., Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA., Voight BF; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Han BG; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Jenkinson CP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.; Research, South Texas Veterans Health Care System, San Antonio, Texas, USA., Kuulasmaa T; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Kuusisto J; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Balkau B; Centre for Research in Epidemiology and Population Health, Inserm U1018, Villejuif, France., Stančáková A; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Abboud HE; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Boeing H; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Prabhakaran D; Centre for Chronic Disease Control, New Delhi, India., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Scott J; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Carey J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Kwan P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Grant G; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Smith JD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Purcell S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA., Butterworth AS; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Howson JMM; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lee HM; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Kwak SH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Zhao W; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Danesh J; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lam VKL; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Park KS; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Aguilar D; Cardiovascular Division, Baylor College of Medicine, Houston, Texas, USA., Arya R; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore., Navarro C; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.; Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Spain., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Palli D; Cancer Research and Prevention Institute (ISPO), Florence, Italy., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Curran JE; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Brownsville, Texas, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Farook VS; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Fowler SP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Griswold M; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Hale DE; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Hicks PJ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Division of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Kumar S; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Brownsville, Texas, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Thuillier D; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Lim WY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Division of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Musani SK; Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA., Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Yengo L; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Tan ST; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Taylor HA; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Thameem F; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Wilson G; College of Public Services, Jackson State University, Jackson, Mississippi, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Njølstad PR; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway., Levy JC; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Schwarzmayr T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fadista J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Surdulescu GL; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Herder C; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wieland T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Doney ASF; Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Kinnunen L; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Esko T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA., Farmer AJ; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hakaste L; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Hodgkiss D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Kravic J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Public Health, Institute of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Ladenvall C; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Justesen JM; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Kriebel J; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rathmann W; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Lannfelt L; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Lauritzen T; Department of Public Health, Section of General Practice, Aarhus University, Aarhus, Denmark., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Melander O; Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University, Malmö, Sweden., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Orho-Melander M; Department of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden., Qi L; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Qi Q; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA., Roden M; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Swift A; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Rosengren AH; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Stirrups K; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Blancher C; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Carneiro MO; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Maguire J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Poplin R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Shakir K; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Fennell T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., DePristo M; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., de Angelis MH; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany., Deloukas P; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jun G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nilsson P; Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden., Murphy J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Onofrio R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Thorand B; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Meisinger C; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hu FB; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA., Isomaa B; Folkhälsan Research Centre, Helsinki, Finland.; Department of Social Services and Health Care, Jakobstad, Finland., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Liang L; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Peters A; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Huth C; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., O'Rahilly SP; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rauramaa R; Foundation for Research in Health, Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Tuomilehto J; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Dasman Diabetes Institute, Dasman, Kuwait.; National Institute for Health and Welfare, Helsinki, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Syvänen AC; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USA., Bharadwaj D; Functional Genomics Unit, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi, India., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Chandak GR; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India., Chan JC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Chia KS; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Daly MJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Ebrahim SB; Centre for Chronic Disease Control, New Delhi, India., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Jablonski KA; The Biostatistics Center, The George Washington University, Rockville, Maryland, USA., Lehman DM; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Jia W; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Pollin TI; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sandhu M; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tandon N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Froguel P; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Barroso I; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Grallert H; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Walker M; The Medical School, Institute of Cellular Medicine, Newcastle University, Newcastle, UK., Banks E; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ingelsson E; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Im HK; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hanover, Germany.; Department of Human Genetics, Hannover Medical School, Hanover, Germany., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Buck G; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Trakalo J; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Buck D; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Farjoun Y; Data Sciences and Data Engineering, Broad Institute, Cambridge, Massachusetts, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Gloyn AL; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany., Tuomi T; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Lee JY; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Park T; Department of Statistics, Seoul National University, Seoul, Republic of Korea.; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Donnelly P; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Atzmon G; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA.; Department of Natural Science, University of Haifa, Haifa, Israel., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Laakso M; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Strom TM; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Bell GI; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA., Blangero J; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Brownsville, Texas, USA., Duggirala R; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School Singapore, Singapore, Singapore., McVean G; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Seielstad M; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.; Blood Systems Research Institute, San Francisco, California, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Meigs JB; General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Cox NJ; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Sladek R; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada., Lander ES; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gabriel S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Kang HM; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Altshuler D; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Publikováno v:
Scientific data [Sci Data] 2017 Dec 19; Vol. 4, pp. 170179. Date of Electronic Publication: 2017 Dec 19.
Autor:
Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Gaulton KJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Genetics, Stanford University, Stanford, CA., Kaakinen M; Department of Genomics of Common Disease, Imperial College London, London, U.K., Pervjakova N; Estonian Genome Center, University of Tartu, Tartu, Estonia., Pers TH; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Johnson AD; Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham, MA., Eicher JD; Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham, MA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K., Lee Y; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Ma C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Steinthorsdottir V; deCODE genetics, Amgen, Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics, Amgen, Inc., Reykjavik, Iceland., Qi L; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Van Zuydam NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics and Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, U.K., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K., Chen H; Human Genetics Center and Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Center for Precision Health, School Biomedical Informatics, and School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Almgren P; Lund University Diabetes Centre and Department of Clinical Sciences Malmö, University Hospital Scania, Lund University, Malmö, Sweden., Voight BF; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Grallert H; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Munich Heart Alliance, German Centre for Cardiovascular Disease, Munich, Germany., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.; Wellcome Trust Sanger Institute, Hinxton, U.K., Robertson N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K., Karssen LC; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; PolyOmica, 's-Hertogenbosch, the Netherlands., van Leeuwen EM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Willems SM; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Kwan P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Chanda P; High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD., Li M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY., Dina C; l'institut du thorax, INSERM, CNRS, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France., Thuillier D; Lille Institute of Biology, European Genomics Institute of Diabetes, Lille, France.; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Yengo L; Lille Institute of Biology, European Genomics Institute of Diabetes, Lille, France.; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Jiang L; Department of Genomics of Common Disease, Imperial College London, London, U.K., Sparso T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kestler HA; Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.; Institute of Medical Systems Biology, Ulm University, Ulm, Germany., Chheda H; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Eisele L; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany., Gustafsson S; Molecular Epidemiology, Department of Medical Sciences, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Frånberg M; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Science for Life Laboratory, Stockholm, Sweden.; Department for Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Benediktsson R; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Landspítali University Hospital, Reykjavik, Iceland., Hreidarsson AB; Landspítali University Hospital, Reykjavik, Iceland., Kong A; deCODE genetics, Amgen, Inc., Reykjavik, Iceland., Sigurðsson G; Landspítali University Hospital, Reykjavik, Iceland.; Icelandic Heart Association, Kópavogur, Iceland., Kerrison ND; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Liang L; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA., Meitinger T; Munich Heart Alliance, German Centre for Cardiovascular Disease, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Roden M; German Center for Diabetes Research, Neuherberg, Germany.; Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Thorand B; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Division of Genetics and Endocrinology, Boston Children's Hospital, Boston, MA., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Fox C; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA.; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Rybin D; Data Coordinating Center, Boston University School of Public Health, Boston, MA., Isomaa B; Folkhälsan Research Center, Helsinki, Finland.; Department of Social Services and Health Care, Jakobstad, Finland., Lyssenko V; Lund University Diabetes Centre and Department of Clinical Sciences Malmö, University Hospital Scania, Lund University, Malmö, Sweden., Tuomi T; Folkhälsan Research Center, Helsinki, Finland.; Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Couper DJ; Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Pankow JS; Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Have CT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.; Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Cornelis MC; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL., van Dam RM; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Hunter DJ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA., Sun Q; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Edkins S; Wellcome Trust Sanger Institute, Hinxton, U.K., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.; National Institute for Health Research Oxford Biomedical Research Centre, Churchill Hospital, Oxford, U.K., Perry JRB; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, U.K., Zeggini E; Wellcome Trust Sanger Institute, Hinxton, U.K., Tajes-Fernandes J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Bonnycastle LL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Chines PS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Endocrinology, Department of Medicine and Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland., Kinnunen L; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Endocrinology, Department of Medicine and Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland., Sennblad B; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Science for Life Laboratory, Stockholm, Sweden., Mühleisen TW; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany., Baldassarre D; Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy., Gertow K; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Humphries SE; Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Sciences, University College London, London, U.K., Tremoli E; Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy., Klopp N; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany., Meyer J; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Steinbach G; Department of Clinical Chemistry and Central Laboratory, University of Ulm, Ulm, Germany., Wennauer R; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Eriksson JG; Folkhälsan Research Center, Helsinki, Finland.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland., Mӓnnistö S; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland., Peltonen L; Wellcome Trust Sanger Institute, Hinxton, U.K.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA., Tikkanen E; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland., Charpentier G; Endocrinology-Diabetology Unit, Corbeil-Essonnes Hospital, Corbeil-Essonnes, France., Eury E; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Lobbens S; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Gigante B; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Leander K; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., McLeod O; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Ruderfer D; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY., Blüher M; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Department of Medicine, University of Leipzig, Leipzig, Germany., Kovacs P; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Department of Medicine, University of Leipzig, Leipzig, Germany., Tonjes A; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Department of Medicine, University of Leipzig, Leipzig, Germany., Maruthur NM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.; Division of General Internal Medicine, Department of Medicine, Johns Hopkins Bloomberg School of Medicine, Baltimore, MD.; The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Erbel R; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Stumvoll M; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Department of Medicine, University of Leipzig, Leipzig, Germany., Deloukas P; Wellcome Trust Sanger Institute, Hinxton, U.K.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, U.K., Donnelly PJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Statistics, University of Oxford, Oxford, U.K., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, U.K., Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K., Ripatti S; Wellcome Trust Sanger Institute, Hinxton, U.K.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Boehm BO; Division of Endocrinology and Diabetes, Department of Internal Medicine, University Medical Centre Ulm, Ulm, Germany.; Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, Singapore., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Collins FS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC., Tuomilehto J; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.; Dasman Diabetes Institute, Dasman, Kuwait.; Centre for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Barroso I; Wellcome Trust Sanger Institute, Hinxton, U.K.; University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital Cambridge, Cambridge, U.K., Lannfelt L; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Ingelsson E; Molecular Epidemiology, Department of Medical Sciences, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA., Lind L; Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Broad Institute of MIT and Harvard, Cambridge, MA., Cauchi S; Lille Institute of Biology, European Genomics Institute of Diabetes, Lille, France., Froguel P; Department of Genomics of Common Disease, Imperial College London, London, U.K.; Lille Institute of Biology, European Genomics Institute of Diabetes, Lille, France.; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Balkau B; INSERM, CESP, UMR 1018, Villejuif, France.; University of Paris-Sud, UMR 1018, Villejuif, France., Boeing H; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Franks PW; Lund University, Malmö, Sweden.; Umeå University, Umeå, Sweden., Barricarte Gurrea A; Navarra Public Health Institute, Pamplona, Spain.; Navarra Institute for Health Research, Pamplona, Spain.; CIBER Epidemiology and Public Health, Madrid, Spain., Palli D; Cancer Research and Prevention Institute, Florence, Italy., van der Schouw YT; University Medical Center Utrecht, Utrecht, the Netherlands., Altshuler D; Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Department of Genetics, Harvard Medical School, Boston, MA.; Department of Molecular Biology, Harvard Medical School, Boston, MA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA., Groop LC; Lund University Diabetes Centre and Department of Clinical Sciences Malmö, University Hospital Scania, Lund University, Malmö, Sweden.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Sijbrands E; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Netherlands Genomics Initiative, Netherlands Consortium for Healthy Ageing and Center for Medical Systems Biology, Rotterdam, the Netherlands., Florez JC; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Diabetes Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; General Medicine Division, Massachusetts General Hospital, Boston, MA., Boerwinkle E; Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Morris AD; Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, U.K., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics and Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, U.K.; Cardiovascular and Diabetes Medicine, Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, U.K., Hu FB; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Thorsteinsdottir U; deCODE genetics, Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Stefansson K; deCODE genetics, Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Dupuis J; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Morris AP; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Biostatistics, University of Liverpool, Liverpool, U.K.; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, U.K., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI boehnke@umich.edu., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K. mark.mccarthy@drl.ox.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.; National Institute for Health Research Oxford Biomedical Research Centre, Churchill Hospital, Oxford, U.K., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K. i.prokopenko@imperial.ac.uk.; Department of Genomics of Common Disease, Imperial College London, London, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.
Publikováno v:
Diabetes [Diabetes] 2017 Nov; Vol. 66 (11), pp. 2888-2902. Date of Electronic Publication: 2017 May 31.
Autor:
Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Highland HM; Human Genetics Center, The University of Texas MD Anderson Cancer Center and The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX.; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Gasser J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Sim X; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Tukiainen T; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Department of Genetics, Harvard Medical School, Boston, MA., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; 23andMe, Mountain View, CA., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Locke AE; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Cingolani P; School of Computer Science, McGill University, Montreal, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Canada., Pers TH; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Divisions of Endocrinology and Genetics and Genomics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Viñuela A; Department of Twin Research & Genetic Epidemiology, King's College London, London, U.K.; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva, University of Geneva, Geneva, Switzerland., Brown AA; Wellcome Trust Sanger Institute, Hinxton, U.K.; Norwegian Centre for Mental Disorders Research and KG Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Wu Y; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Flannick J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Gamazon ER; Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL.; Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Department of Pediatrics, University of California, San Diego, La Jolla, CA., Im HK; Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Blackwell TW; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Chen Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Green T; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Hartl C; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Kang HM; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Kumar A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Chronic Disease Epidemiology Unit, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland., Ladenvall C; Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden., Ma C; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Moutsianas L; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Pearson RD; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Perry JRB; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., van de Bunt M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Vaasa Central Hospital, Vaasa, Finland.; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Jula A; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Koskinen S; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland., Palotie A; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Jacobs SBR; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, IN.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Goodarzi MO; Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA., Blancher C; High-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Buck G; High-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Buck D; High-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Chines PS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Gabriel S; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Groves CJ; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Jun G; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Justesen JM; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mangino M; Department of Twin Research & Genetic Epidemiology, King's College London, London, U.K., Murphy J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Neville M; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Onofrio R; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Small KS; Department of Twin Research & Genetic Epidemiology, King's College London, London, U.K., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Trakalo J; High-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Banks E; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Carey J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Carneiro MO; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., DePristo M; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Farjoun Y; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Fennell T; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Goldstein JI; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA., Grant G; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Hrabé de Angelis M; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Freising, Germany., Maguire J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Neale BM; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA., Poplin R; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Purcell S; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Department of Psychiatry, Icahn Institute for Genomics & Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY., Schwarzmayr T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Shakir K; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Smith JD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA., Strom TM; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Neuherberg, Germany., Wieland T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Lindstrom J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland., Brandslund I; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Surdulescu GL; Department of Twin Research & Genetic Epidemiology, King's College London, London, U.K., Lakka TA; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Doney ASF; Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, U.K., Nilsson P; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Varga TV; Department of Clinical Sciences, Lund University Diabetes Centre, and Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, and Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Rosengren AH; Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden., Farook VS; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX., Thameem F; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX., Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX., Kumar S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX., Lehman DM; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX., Jenkinson CP; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX., Curran JE; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX., Hale DE; Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX., Fowler SP; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX., Arya R; Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX., DeFronzo RA; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX., Abboud HE; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX., Syvänen AC; Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Hicks PJ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC., Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC., Esko T; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Department of Genetics, Harvard Medical School, Boston, MA.; Division of Endocrinology, Boston Children's Hospital, Boston, MA.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Narisu N; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Kinnunen L; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Bonnycastle LL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Swift A; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K., Fadista J; Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden., Pollin TI; Program in Personalized and Genomic Medicine, Department of Medicine, University of Maryland, Baltimore, MD., Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, NY., Atzmon G; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, NY.; Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Thorand B; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Peters A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Roden M; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research, Partner Düsseldorf, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany., Liang L; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA., Kriebel J; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Illig T; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Meisinger C; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Lannfelt L; Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Musani SK; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS., Griswold M; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS., Taylor HA Jr; Department of Medicine, University of Mississippi Medical Center, Jackson, MS., Wilson G Sr; College of Public Services, Jackson State University, Jackson, MS., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS., Oksa H; Pirkanmaa Hospital District, Tampere, Finland., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, U.K., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, U.K., Tan ST; Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, U.K., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, U.K.; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Singapore., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, U.K.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, U.K.; Imperial College Healthcare NHS Trust, Imperial College London, London, U.K., Sehmi J; Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, U.K., Kooner JS; Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, U.K., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Lee JY; Ministry of Health and Welfare, Seoul, Republic of Korea., Han BG; Center for Genome Science, Korea National Research Institute of Health, Chungcheongbuk-do, Republic of Korea., Käräjämäki A; Vaasa Health Care Center, Vaasa, Finland.; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland., Qi Q; Department of Nutrition, Harvard School of Public Health, Boston, MA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY., Qi L; Department of Nutrition, Harvard School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, MA., Hu FB; Department of Nutrition, Harvard School of Public Health, Boston, MA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA., Melander O; Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö, Sweden., Orho-Melander M; Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden., Below JE; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Aguilar D; Cardiovascular Division, Baylor College of Medicine, Houston, TX., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Division of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Division of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chia KS; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Lim WY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore, Singapore., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cardiovascular & Metabolic Disorders Program, Duke-NUS Graduate Medical School Singapore, Singapore., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Linneberg A; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Isomaa B; Folkhälsan Research Center, Helsinki, Finland.; Department of Social Services and Health Care, Jakobstad, Finland., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Neuherberg, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Tuomi T; Folkhälsan Research Center, Helsinki, Finland.; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland., Hakaste L; Folkhälsan Research Center, Helsinki, Finland., Kravic J; Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Lauritzen T; Section of General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark., Deloukas P; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K., Stirrups KE; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.; Department of Haematology, University of Cambridge, Cambridge, U.K., Owen KR; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, U.K., Farmer AJ; Department of Primary Care Health Sciences, University of Oxford, Oxford, U.K., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K., O'Rahilly SP; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Walker M; Institute of Cellular Medicine, University of Newcastle, Newcastle, U.K., Levy JC; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Hodgkiss D; Department of Twin Research & Genetic Epidemiology, King's College London, London, U.K., Hattersley AT; University of Exeter Medical School, Exeter, U.K., Kuulasmaa T; Internal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Stančáková A; Internal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Barroso I; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K.; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Bharadwaj D; Functional Genomics Unit, CSIR-Institute of Genomics & Integrative Biology, New Delhi, India., Chan J; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Chandak GR; CSIR-Centre for Cellular & Molecular Biology, Hyderabad, India., Daly MJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA., Donnelly PJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Department of Statistics, University of Oxford, Oxford, U.K., Ebrahim SB; Centre for Chronic Disease Control, New Delhi, India., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, U.K.; MRC-PHE Centre for Environment & Health, Imperial College London, London, U.K., Fingerlin T; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO., Froguel P; Genomics and Molecular Physiology, CNRS Institut de Biologie de Lille, Lille, France., Hu C; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Jia W; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., McVean G; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Park T; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Prabhakaran D; Centre for Chronic Disease Control, New Delhi, India., Sandhu M; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K.; Institute of Public Health, Department of Public Health and Primary Care, University of Cambridge, Cambridge, U.K., Scott J; Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K., Sladek R; McGill University and Génome Québec Innovation Centre, Montreal, Canada.; Department of Human Genetics, McGill University, Montreal, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Canada., Tandon N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Diabetes & Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine and Abdominal Center, Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kesaniemi YA; Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, London, U.K., Salomaa V; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, U.K., Prokopenko I; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, U.K., Morris AD; Division for Molecular Medicine, Clinical Research Centre, Ninewells Hospital and Medical School, Dundee, U.K., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Collins FS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Ingelsson E; Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA., Tuomilehto J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Dasman Diabetes Institute, Dasman, Kuwait., Karpe F; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, U.K., Groop L; Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden., Jørgensen T; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.; Faculty of Medicine, University of Aalborg, Aalborg, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kuusisto J; Internal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Bell GI; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, IL., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX., Cox NJ; Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL., Duggirala R; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX., Seielstad M; Department of Laboratory Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA.; Blood Systems Research Institute, San Francisco, CA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA., Ripatti S; Wellcome Trust Sanger Institute, Hinxton, U.K.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Hjelt Institute, University of Helsinki, Helsinki, Finland., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, MA., Mohlke KL; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Meigs JB; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA., Laakso M; Internal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, U.K., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Altshuler D; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Department of Genetics, Harvard Medical School, Boston, MA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, MA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., McCarthy MI; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, U.K., Gloyn AL; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, U.K., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
Publikováno v:
Diabetes [Diabetes] 2017 Jul; Vol. 66 (7), pp. 2019-2032. Date of Electronic Publication: 2017 Mar 24.
Autor:
Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.; Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC), affiliated with the University of Lübeck, Bolzano, Italy., Flannick J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Agarwala V; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ma C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Moutsianas L; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McCarthy DJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Perry JRB; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Blackwell TW; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Cingolani P; School of Computer Science, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Tajes JF; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Highland HM; Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hartl C; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Chen H; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., van de Bunt M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Pearson RD; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kumar A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Gamazon ER; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Lee J; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Chen Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Below JE; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Chen P; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Go MJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Parker SCJ; Departments of Computational Medicine & Bioinformatics and Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Varga TV; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Green T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Beer NL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Day-Williams AG; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fingerlin T; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA., Horikoshi M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hu C; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Huh I; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Ikram MK; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Kim BJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kim Y; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Kim YJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kwon MS; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Lee J; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Lee S; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Lin KH; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Maxwell TJ; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nagai Y; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Welch RP; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Yoon J; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK., Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA., Voight BF; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Han BG; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Jenkinson CP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.; Research, South Texas Veterans Health Care System, San Antonio, Texas, USA., Kuulasmaa T; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Kuusisto J; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Balkau B; Centre for Research in Epidemiology and Population Health, Inserm U1018, Villejuif, France., Stančáková A; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Abboud HE; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Boeing H; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Prabhakaran D; Centre for Chronic Disease Control, New Delhi, India., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Scott J; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Carey J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Kwan P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Grant G; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Smith JD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Purcell S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA., Butterworth AS; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Howson JMM; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lee HM; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Kwak SH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Zhao W; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Danesh J; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lam VKL; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Park KS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Aguilar D; Cardiovascular Division, Baylor College of Medicine, Houston, Texas, USA., Arya R; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore., Navarro C; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.; Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Spain., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Palli D; Cancer Research and Prevention Institute (ISPO), Florence, Italy., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Curran JE; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Farook VS; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Fowler SP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Griswold M; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Hale DE; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Hicks PJ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Division of Human Genetics, Genome Institute of Singapore, ASTAR, Singapore., Kumar S; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Thuillier D; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Lim WY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Division of Human Genetics, Genome Institute of Singapore, ASTAR, Singapore., van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore., Musani SK; Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA., Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Yengo L; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Tan ST; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Taylor HA Jr; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Thameem F; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Wilson G Sr; College of Public Services, Jackson State University, Jackson, Mississippi, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Njølstad PR; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway., Levy JC; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Schwarzmayr T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fadista J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Surdulescu GL; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Herder C; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wieland T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Doney ASF; Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Kinnunen L; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Esko T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA., Farmer AJ; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hakaste L; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Hodgkiss D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Kravic J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Public Health, Institute of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Ladenvall C; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Justesen JM; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Kriebel J; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rathmann W; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Lannfelt L; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Lauritzen T; Department of Public Health, Section of General Practice, Aarhus University, Aarhus, Denmark., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Melander O; Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University, Malmö, Sweden., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Orho-Melander M; Department of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden., Qi L; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Qi Q; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA., Roden M; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Swift A; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Rosengren AH; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Stirrups K; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Blancher C; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Carneiro MO; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Maguire J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Poplin R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Shakir K; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Fennell T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., DePristo M; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., de Angelis MH; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jun G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nilsson P; Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden., Murphy J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Onofrio R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Thorand B; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Meisinger C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hu FB; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA., Isomaa B; Folkhälsan Research Centre, Helsinki, Finland.; Department of Social Services and Health Care, Jakobstad, Finland., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Liang L; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Peters A; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Huth C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., O'Rahilly SP; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rauramaa R; Foundation for Research in Health, Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Tuomilehto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain.; National Institute for Health and Welfare, Helsinki, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Syvänen AC; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USA., Bharadwaj D; Functional Genomics Unit, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi, India., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Chandak GR; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India., Chan JCN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Chia KS; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Daly MJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Ebrahim SB; Centre for Chronic Disease Control, New Delhi, India., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Jablonski KA; The Biostatistics Center, The George Washington University, Rockville, Maryland, USA., Lehman DM; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Jia W; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Pollin TI; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sandhu M; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tandon N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Froguel P; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Barroso I; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Walker M; The Medical School, Institute of Cellular Medicine, Newcastle University, Newcastle, UK., Banks E; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ingelsson E; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Im HK; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hanover, Germany.; Institute for Human Genetics, Hannover Medical School, Hanover, Germany., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Buck G; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Trakalo J; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Buck D; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Farjoun Y; Data Sciences and Data Engineering, Broad Institute, Cambridge, Massachusetts, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Gloyn AL; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Tuomi T; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Lee JY; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Park T; Department of Statistics, Seoul National University, Seoul, Republic of Korea.; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Donnelly P; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Atzmon G; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA.; Department of Natural Science, University of Haifa, Haifa, Israel., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Laakso M; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Strom TM; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Bell GI; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA., Blangero J; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Duggirala R; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School Singapore, Singapore., McVean G; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Seielstad M; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.; Blood Systems Research Institute, San Francisco, California, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Meigs JB; General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Cox NJ; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Sladek R; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada., Lander ES; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gabriel S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Kang HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Altshuler D; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Publikováno v:
Nature [Nature] 2016 Aug 04; Vol. 536 (7614), pp. 41-47. Date of Electronic Publication: 2016 Jul 11.
Autor:
Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Erdos MR; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Welch RP; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Beck AT; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Wolford BN; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Chines PS; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Didion JP; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Narisu N; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Taylor DL; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Vadlamudi S; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Bonnycastle LL; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Kinnunen L; Department of Health, National Institute for Health and Welfare, P.O. Box 30, Helsinki FI-00271, Finland., Saramies J; South Karelia Central Hospital, Lappeenranta 53130, Finland., Sundvall J; Department of Health, National Institute for Health and Welfare, P.O. Box 30, Helsinki FI-00271, Finland., Albanus RD; Department of Computational Medicine &Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kiseleva A; Department of Computational Medicine &Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Hensley J; Department of Computational Medicine &Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Crawford GE; Center for Genomic &Computational Biology, Duke University, Durham, North Carolina 27708, USA.; Department of Pediatrics, Division of Medical Genetics, Duke University Medical Center, Durham, North Carolina 27708, USA., Jiang H; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Wen X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, California 90089, USA.; Department of Physiology and Biophysics, Keck School of Medicine of USC, Los Angeles, California 90089, USA., Lakka TA; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio FI-00100, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio FI-00100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio FI-00100, Finland., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Laakso M; Department of Medicine, University of Eastern Finland, Kuopio FI-00100, Finland.; Kuopio University Hospital, Kuopio FI-00100, Finland., Tuomilehto J; Chronic Disease Prevention Unit, National Institute for Health and Welfare, P.O. Box 30, Helsinki FI-00271, Finland.; Center for Vascular Prevention, Danube University Krems, Krems 3500, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Dasman Diabetes Institute, Dasman 15461, Kuwait., Koistinen HA; Department of Health, National Institute for Health and Welfare, P.O. Box 30, Helsinki FI-00271, Finland.; Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki FI-00290, Finland., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Collins FS; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Parker SC; Department of Computational Medicine &Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Publikováno v:
Nature communications [Nat Commun] 2016 Jun 29; Vol. 7, pp. 11764. Date of Electronic Publication: 2016 Jun 29.
Autor:
Gaulton KJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Genetics, Stanford University, Stanford, California, USA., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Lee Y; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Raimondo A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Reschen ME; Centre for Cellular and Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Locke A; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Robertson N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Scott RA; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Prokopenko I; Genomics of Common Disease, Imperial College London, London, UK., Scott LJ; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Green T; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Sparso T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Thuillier D; Lille Institute of Biology, European Genomics Institute of Diabetes, Lille, France., Yengo L; Lille Institute of Biology, European Genomics Institute of Diabetes, Lille, France., Grallert H; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Wahl S; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Frånberg M; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Science for Life Laboratory, Stockholm, Sweden.; Department for Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden., Strawbridge RJ; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Kestler H; Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany.; Medical Systems Biology, Ulm University, Ulm, Germany., Chheda H; Finnish Institute for Molecular Medicine (FIMM), Helsinki, Finland., Eisele L; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Steinthorsdottir V; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Thorleifsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Qi L; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA., Karssen LC; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., van Leeuwen EM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Willems SM; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Li M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Chen H; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA., Fuchsberger C; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Kwan P; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Ma C; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Linderman M; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lu Y; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Thomsen SK; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Rundle JK; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Beer NL; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., van de Bunt M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Chalisey A; Centre for Cellular and Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kang HM; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Voight BF; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Abecasis GR; 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Publikováno v:
Nature genetics [Nat Genet] 2015 Dec; Vol. 47 (12), pp. 1415-25. Date of Electronic Publication: 2015 Nov 09.
Autor:
Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Ng HJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Highland HM; Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Im HK; Department of Health Studies, Biostatistics Laboratory, The University of Chicago, Chicago, Illinois, United States of America., Cingolani P; School of Computer Science, McGill University, Montreal, Quebec, Canada; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Flannick J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Beer NL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Rundle JK; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Bork-Jensen J; 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Publikováno v:
PLoS genetics [PLoS Genet] 2015 Jan 27; Vol. 11 (1), pp. e1004876. Date of Electronic Publication: 2015 Jan 27 (Print Publication: 2015).