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Publikováno v:
Journal of Pharmacy and Pharmacology. 70:1102-1112
ObjectivesInflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to explore the anti-inflammatory role of PTY-2r (extracted from Pueraria tuberosa), on streptozotocin (STZ)-induced DN rats.Met
Autor:
A. R. Moedas, Elsa Nunes, Pedro Monteiro, C. Amaral, T. Louro, Joana Crisóstomo, Paulo Matafome, Raquel Seiça, A. Cipriano, Lisa Rodrigues
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as we
Autor:
Kimberly G. Freeman, Emily W Kelso, Darin E. Olson, Adam G. Campbell, William P. Flatt, Marty H Porter, Peter M. Thulé
Publikováno v:
Molecular Therapy. 16:1235-1242
Previous studies of hepatic insulin gene therapy (HIGT) focused on glycemic effects of insulin produced from hepatocytes. In this study, we extend the observations of glycemic control with metabolically regulated HIGT to include systemic responses an
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:1216-1223
Streptozotocin (STZ)-induced diabetes can modulate dopamine (DA) neurotransmission and thereby modify the behavioral effects of drugs acting on DA systems. Insulin replacement, and in some conditions repeated treatment with amphetamine, can partially
Autor:
Hironobu Kakuta, Nigishi Hotta, Tomohiro Hara, Keiko Naruse, Fumihiko Sakakibara, Hideo Fukasawa, Yoji Hamada, Nobuo Sakamoto, Koichi Mori, Jiro Nakamura, Naoki Koh
Publikováno v:
European Journal of Pharmacology. 313:201-209
To investigate the pathogenesis of diabetic neuropathy in non-insulin-dependent diabetes mellitus, Otsuka Long-Evans Tokushima Fatty rats, an animal model of non-insulin-dependent diabetes mellitus, and non-diabetic Long-Evans Tokushima Otsuka rats w
Publikováno v:
European Journal of Pharmacology. 216:123-126
The effects of sodium orthovanadate (0.6 mg/ml in drinking water) on hexokinase isozymes, pyruvate kinase and malic enzyme in liver and kidney of control and alloxan diabetic rats were studied and compared. Vanadate treatment of diabetic rats normali
Publikováno v:
Scopus-Elsevier
1. Hippocampal slices have been used to assess the sensitivity of the CNS to adenosine and gamma-aminobutyric acid (GABA) in diabetes. The effects of adenosine, 2-chloroadenosine, GABA, muscimol and baclofen were studied on orthodromic synaptic poten
Publikováno v:
Diabetes. 40:931-938
This study examined the effect of cyclosporin on the survival of islet β-cell allografts in streptozocin (STZ)-induced diabetic rats. At a daily oral dose of 5 mg/kg, the agent prevented the rejection of isolated islets, provided they were little co
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:746-751
The activity of lipoprotein lipase was measured in white and brown adipose tissues, red vastus lateralis muscle, and heart of rats that have been insulin deficient (streptozotocin, 75 mg∙kg−1) for 2 weeks, and that have then received implants of
Publikováno v:
Pharmacology Biochemistry and Behavior. 39:383-387
Molecular components in transmembrane signaling may be dysfunctional in insulin-deficient states. To investigate whether the alpha 2 adrenergic receptor-effector mechanism is functionally altered by insulin deficiency, we determined the hypnotic resp