Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sarah A. Tersey"'
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2151, p 2151 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 2151, p 2151 (2021)
Type 2 diabetes (T2D) typically occurs in the setting of obesity and insulin resistance, where hyperglycemia is associated with decreased pancreatic β-cell mass and function. Loss of β-cell mass has variably been attributed to β-cell dedifferentia
Autor:
Annie Rocio Pineros Alverez, Natalie D. Stull, Donalyn Scheuner, Michael Pugia, Sarah A. Tersey, Dylan Frabutt, Teresa Mastracci
Publikováno v:
Archives of autoimmune diseases
The protein hormone adiponectin regulates glucose and fatty acid metabolism by binding to two PAQR-family receptors (AdipoR1 and AdipoR2). Both receptors feature a C-terminal segment which is released by proteolysis to form a freely-circulating C-ter
Publikováno v:
J Diabetes Complications
Background Obesity and the metabolic syndrome are increasingly prevalent in society and their complications and response to treatment exhibit sexual dimorphism. Mouse models of high fat diet-induced obesity are commonly used for both mechanistic and
Autor:
Abhishek Kulkarni, Margaret A. Morris, Marcia McDuffie, Lindsey Glenn, Maureen Gannon, Christopher A. Reissaus, Kara S. Orr, Sarah A. Tersey, Marimar Hernandez-Perez, Jerry L. Nadler, Annie R. Piñeros, Raghavendra G. Mirmira
Publikováno v:
Diabetes. 69
The type 1 diabetes (T1D) pathogenesis has been viewed as being initiated and propagated by directed autoimmunity against islet β cells. In recent years, we and others have taken a new perspective placing the β cell itself as the initiating cell. 1
Autor:
Marco Bugliani, François Fuks, Miriam Cnop, Silva A. Arslanian, Jamie L. Felton, Raghavendra G. Mirmira, Farooq Syed, Kieren J. Mather, Ezio Bonifacio, Nicole Jiyun Kang, Anette-Gabriele Ziegler, Mathieu Defrance, Sarah A. Tersey, Carmella Evans-Molina, Appakalai N. Balamurugan, Jennifer Nelson, Jean-Valery Turatsinze, Decio L. Eizirik, Emily K. Sims, Bobbie-Jo M. Webb-Robertson, Martin Bizet, Piero Marchetti
Publikováno v:
Clinical Epigenetics
Clinical Epigenetics, 12 (1
Clinical Epigenetics, 12 (1
BACKGROUND: Identification of islet β cell death prior to the onset of type 1 diabetes (T1D) or type 2 diabetes (T2D) might allow for interventions to protect β cells and reduce diabetes risk. Circulating unmethylated DNA fragments arising from the
Autor:
Ryan M. Anderson, Gaurav Chopra, Chanelle Benjamin, Jonathan Fine, Jerry L. Nadler, Raghavendra G. Mirmira, Abass M. Conteh, Sarah A. Tersey, David J. Maloney, Marimar Hernandez-Perez, Jennifer B. Nelson, Kara S. Benninger, Amelia K. Linnemann
Publikováno v:
Diabetes
Islet β-cell dysfunction and aggressive macrophage activity are early features in the pathogenesis of type 1 diabetes (T1D). 12/15-Lipoxygenase (12/15-LOX) is induced in β-cells and macrophages during T1D and produces proinflammatory lipids and lip
Autor:
Raghavendra G. Mirmira, Ashok Balasubramanyam, Surya N. Mulukutla, Sarah A. Tersey, Christiane S. Hampe
Publikováno v:
Journal of Diabetes and its Complications. 32:193-195
A + β + ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevate
Autor:
Kara S. Orr, Maureen Gannon, Sarah A. Tersey, Jerry L. Nadler, Raghavendra G. Mirmira, Christopher A. Reissaus, Abhishek Kulkarni, Margaret A. Morris, Marcia McDuffie, Marimar Hernandez-Perez, Annie Rocio Pineros Alvarez, Lindsey Glenn
Publikováno v:
Diabetes. 68
The pathogenesis of type 1 diabetes (T1D) involves the interaction of the immune system with β cells. 12/15-lipoxygenase (12/15-LOX), an enzyme involved in arachidonic acid metabolism, is expressed in both β cells and macrophages. Global deletion o
Autor:
Kara S. Orr, Andrew Pearson, Lindsey Glenn, David Taylor, Sarah A. Tersey, David A. Taylor-Fishwick
Publikováno v:
Integrative Molecular Medicine. 6
Autor:
Pieter Gillard, Frans Gorus, Zhidong Ling, Eric V. Balti, Sarah A. Tersey, Olivier Costa, Geert Stangé, Daniel Pipeleers, Bart Keymeulen, Sarah Roels, Raghavendra G. Mirmira, Dieter De Smet, Geert A. Martens
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism
AIM: Several biomarkers have been proposed to detect pancreatic β cell destruction in vivo but so far have not been compared for sensitivity and significance. METHODS: We used islet transplantation as a model to compare plasma concentrations of miR-