Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tohru Sugawara"'
Publikováno v:
Regenerative Therapy. 21:37-45
In a diploid organism, two alleles from a single genetic locus are expressed to generate a normal phenotype. Heterozygous deleterious mutation causes a reduction of functional proteins to a half dose and insufficient amounts of functional proteins ca
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 15, Iss, Pp 1-9 (2020)
Regenerative Therapy, Vol 15, Iss, Pp 1-9 (2020)
Introduction Recent studies have revealed that microRNAs (miRNAs, miRs) are important for self-renewal, differentiation, and cellular reprogramming of somatic cells into induced pluripotent stem cells (iPSC); however, their functional roles and targe
Autor:
Hidenori Akutsu, Kenji Miyado, Shoko Miyajima, Tohru Sugawara, Akari Nakamura, Yasunori Yoshimura, Jun Miyauchi, Toshio Hamatani, Seiji Ogawa, Mitsutoshi Yamada, Mamoru Tanaka, Akihiro Umezawa, Akihiro Nakamura, Hideki Tsumura, Yuichirou Harada, Ryuichiro Okawa, Reina Ooka
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1366-1379 (2019)
Summary: Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA genes prevent mitotic errors. Here we show that knockout of the ZGA gene Zscan5b,
Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors
Autor:
Mahito Nakanishi, Manami Ohtaka, Koichiro Nishino, Masashi Toyoda, Hidenori Akutsu, Tohru Sugawara, Yoshikazu Arai, Mayu Yamazaki-Inoue, Akihiro Umezawa, Ken Takasawa, Ken Nishimura
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 9, Iss, Pp 71-78 (2018)
Regenerative Therapy, Vol 9, Iss, Pp 71-78 (2018)
Human induced pluripotent stem cells (iPSCs) are established by introducing several reprogramming factors, such as OCT3/4, SOX2, KLF4, c-MYC. Because of their pluripotency and immortality, iPSCs are considered to be a powerful tool for regenerative m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9157e1b981a74af739f0bafe06369c
https://doi.org/10.1101/355099
https://doi.org/10.1101/355099
Autor:
Kenji Miyado, Takumi Miura, Hidenori Akutsu, Masakazu Machida, Mohan C. Vemuri, Seiichi Kanzaki, Akihiro Umezawa, Mayu Yamazaki-Inoue, Tohru Sugawara, Mahendra S. Rao, Naoko Nakamura, Takashi Ohkura
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 1, Iss C, Pp 18-29 (2015)
Regenerative Therapy, Vol 1, Iss C, Pp 18-29 (2015)
The potential applications of human embryonic stem cells (hESCs) in regenerative medicine and developmental research have made stem cell biology one of the most fascinating and rapidly expanding fields of biomedicine. The first clinical trial of hESC
Autor:
Justin K. Ichida, Takumi Miura, Hidenori Akutsu, Youki Takezawa, Toshio Hamatani, Tohru Sugawara, Naoaki Kuji, Keiichi Yoshida, Noriko Okumura, Kenji Miyado, Akihiro Umezawa, Yasunori Yoshimura, Mitsutoshi Yamada, Akihiro Hosoda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout embryogenesis and tissue homeostasis. β-Catenin, encoded by the Ctnnb1 gene, mediates an intra