Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alf Kozian"'
Autor:
Alf Kozian, Moritz Kretzschmar, James E. Baumgardner, Jens Schreiber, Göran Hedenstierna, Anders Larsson, Thomas Hachenberg, Thomas Schilling
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 939-947 (2015)
The data of a corresponding animal experiment demonstrates that nebulized methacholine (MCh) induced severe bronchoconstriction and significant inhomogeneous ventilation and pulmonary perfusion (V̇A/Q̇) distribution in pigs, which is similar to fin
Externí odkaz:
https://doaj.org/article/4b453bc62bea4015b73e3da30480352f
Autor:
James E. Baumgardner, Thomas Hachenberg, Anders Larsson, Moritz Kretzschmar, Göran Hedenstierna, Thomas F. Schilling, Alf Kozian
Publikováno v:
Anesthesiology. 135:1042-1054
Background Kinetics of the uptake of inhaled anesthetics have been well studied, but the kinetics of elimination might be of more practical importance. The objective of the authors’ study was to assess the effect of the overall ventilation/perfusio
Autor:
Moritz Kretzschmar, Anders Larsson, James E. Baumgardner, Göran Hedenstierna, Thomas Hachenberg, Alf Kozian, Thomas F. Schilling
Publikováno v:
Anesthesiology. 135:1027-1041
Background Previous studies have established the role of various tissue compartments in the kinetics of inhaled anesthetic uptake and elimination. The role of normal lungs in inhaled anesthetic kinetics is less understood. In juvenile pigs with norma
Autor:
Anders Larsson, João Batista Borges, Thomas Hachenberg, Moritz Kretzschmar, Thomas F. Schilling, Alf Kozian, James E. Baumgardner, Göran Hedenstierna
Publikováno v:
Anesthesiology. 127:800-812
BackgroundIncreasing numbers of patients with obstructive lung diseases need anesthesia for surgery. These conditions are associated with pulmonary ventilation/perfusion (VA/Q) mismatch affecting kinetics of volatile anesthetics. Pure shunt might del
Autor:
Thomas Schilling, Thomas Hachenberg, James E. Baumgardner, Alf Kozian, Jens Schreiber, Göran Hedenstierna, Moritz Kretzschmar, Anders Larsson
Publikováno v:
Respiratory Physiology & Neurobiology. 220:88-94
Bronchoconstriction is a hallmark of asthma and impairs gas exchange. We hypothesized that pharmacokinetics of volatile anesthetics would be affected by bronchoconstriction. Ventilation/perfusion (VA/Q) ratios and pharmacokinetics of desflurane in bo
Autor:
Annegret Reinhold, Alf Kozian, Thomas Hachenberg, Mert Şentürk, Thomas F. Schilling, Göran Hedenstierna, Christof Huth
Publikováno v:
Anesthesiology. 115:65-74
Background One-lung ventilation (OLV) results in alveolar proinflammatory effects, whereas their extent may depend on administration of anesthetic drugs. The current study evaluates the effects of different volatile anesthetics compared with an intra
Autor:
Thomas Schilling, Alf Kozian, Christian Breitling, Thomas Hachenberg, Göran Hedenstierna, Christoph Röcken
Publikováno v:
Journal of cardiothoracic and vascular anesthesia. 24(4)
Objective: Mechanical stress during one-lung ventilation (OLV) results in lung injury. This study compared the effects of mechanical ventilation, OLV, and surgical manipulation on diffuse alveolar damage (DAD) after application of different anestheti
Autor:
Frank Bühling, Thomas Hachenberg, Alf Kozian, Tobias Welte, Christof Huth, Göran Hedenstierna, Moritz Kretzschmar, Thomas F. Schilling
Publikováno v:
British journal of anaesthesia. 99(3)
One-lung ventilation (OLV) induces a pro-inflammatory response including cytokine release and leucocyte recruitment in the ventilated lung. Whether volatile or i.v. anaesthetics differentially modulate the alveolar inflammatory response to OLV is unc