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pro vyhledávání: '"Geethu E. Thomas"'
Autor:
Rose Hurren, Razq Hakem, Parasvi S. Patel, Neil MacLean, Grace Egan, Aaron D. Schimmer, Geethu E. Thomas
Publikováno v:
Blood. 136:2-2
While most patients with AML achieve remission with standard induction chemotherapy, the majority ultimately relapse. Relapsed AML is due, at least in part, to the persistence of chemoresistant leukemia stem cells (LSCs). The mechanisms of chemoresis
Autor:
Zachary Blatman, Rose Hurren, Aaron D. Schimmer, Geethu E. Thomas, Samir H. Barghout, Neil MacLean, G. Wei Xu
Publikováno v:
Blood. 132:1350-1350
UBA1 is the major ubiquitin-activating enzyme that initiates the ubiquitylation cascade whereby proteins are tagged with mono- or polyubiquitin to mark them for proteasomal degradation or modify their functions. Despite having equal levels of UBA1 pr