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Autor:
Martina Klaric, Joshua Fernandes, R. Parr-Dobrzanski, P. Fisher, Jeanne Y. Domoradzki, Edgars Felkers, Andreas Schepky, C. Wiemann, Felix M. Kluxen, Nicky J. Hewitt, Sébastien Grégoire, Steven F. McEuen
Publikováno v:
Regulatory Toxicology and Pharmacology. 108:104475
The European Food Safety Authority (EFSA) guidance (EFSA, 2017) for dermal absorption (DA) studies recommends stringent mass balance (MB) limits of 95-105%. EFSA suggested that test material can be lost after penetration and requires that for chemica